4.2.1.46: dTDP-glucose 4,6-dehydratase

This is an abbreviated version!
For detailed information about dTDP-glucose 4,6-dehydratase, go to the full flat file.

Word Map on EC 4.2.1.46

4.2.1.46

dtdp-l-rhamnose

dtdp-4-keto-6-deoxy-d-glucose

3,5-epimerase

dtdp-4-dehydrorhamnose

o-antigen

deoxysugars

dtmp

thymidylyltransferase

6-deoxyhexose

peucetius

analysis

synthesis

pharmacology

Reaction

Synonyms

DesIV, dTDP-D-glucose 4,6-dehydratase, dTDP-D-glucose oxidoreductase, dTDP-glucose-4,6-dehydratase, dTGD, RmbB, rml-2, RmlB, TDP-D-glucose 4,6-dehydratase, TDP-glucose oxidoreductase, TDPDH, Thymidine diphosphate D-glucose oxidoreductase, thymidine diphosphate-glucose 4,6-dehydratase, Thymidine diphospho-D-glucose 4,6-dehydratase, Thymidine diphosphoglucose oxidoreductase, UDP-D-glucose 4,6-dehydratase, Ugd

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.46 dTDP-glucose 4,6-dehydratase

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Results	in table
1	Activating Compound
36877	AA Sequence
7	Application
1	CAS Registry Number
11	Cloned(Commentary)
25	Cofactor
4	Crystallization (Commentary)
6	General Information
2	General Stability
2	IC50 Value
37	Inhibitors
4	Ki Value [mM]
48	KM Value [mM]
4	Metals/Ions
22	Molecular Weight [Da]
64	Natural Substrates/ Products (Substrates)
83	Organism
31	Pathway
35	PDB ID
14	pH Optimum
2	pH Range
1	pH Stability
35	Protein Variants
21	Purification (Commentary)
1	Reaction
1	Reaction Type
82	Reference
13	Specific Activity [micromol/min/mg]
7	Storage Stability
105	Substrates and Products (Substrate)
13	Subunits
111	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
51	Turnover Number [1/s]

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General Information on EC 4.2.1.46 - dTDP-glucose 4,6-dehydratase

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malfunction

Streptomyces peucetius

C5J046

inactivation of rmbB abolishes the production of doxorubicin while complementation of the same gene in an rmbB knockout mutant restores the doxorubicin production

701859

metabolism

4 entries

physiological function

Streptomyces peucetius

C5J046

rmbB provides dTDP-4-dehydro-6-deoxy-D-glucose as a nucleotide sugar precursor for the biosynthesis of doxorubicin

701859