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4.2.1.11: phosphopyruvate hydratase

This is an abbreviated version!
For detailed information about phosphopyruvate hydratase, go to the full flat file.

Word Map on EC 4.2.1.11

Reaction

2-phospho-D-glycerate
=
phosphoenolpyruvate
 +
H2O

Synonyms

14-3-2 protein, 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydrolase, 2-phospho-D-glycerate hydrolyase, 2-phospho-D-glyceratehydrolyase, 2-phosphoglycerate dehydratase, 2-phosphoglycerate enolase, 2-phosphoglycerate hydrolase, 2-phosphoglycerate hydrolyase, 2-phosphoglyceric dehydratase, 2-phosphopyruvate hydrolyase, alpha,alpha-enolase, alpha-enolase, alpha-enolase 1, alpha-enolase 2, Alt a XI, beta,beta-enolase, beta-enolase, Cla h VI, Csenolase, cytotoxin B, EhENO, ENO, ENO-1, Eno-alpha, ENO-S, ENO1, Eno1p, Eno2, ENOA, EnoA I, EnoA1, ENOL, Enol-1, enolase, enolase 1, enolase 2, enolase alpha, enolase gamma, enolase S, enolase-1, enolase-alpha, enolase-beta, Enolase-phosphatase E1, enolase2p, Err2p, Err3p, gamma,gamma-enolase, gamma-enolase, hENO1, HLE1, human alpha-enolase, human neuron-specific enolase, hydratase, phosphoenolpyruvate, Laminin binding protein, Major allergen Alt a 11, MASA, MSE, Neural enolase, neuron specific enolase, neuron-specific enolase, neuronal enolase, NNE, Non-neural enolase, NSE, OSE1, p45, P46, Pfen, Pfeno, phosphoenolpyruvate enolase, phosphoenolpyruvate hydratase, Phosphopyruvate hydratase, plasminogen-binding alpha-enolase, R-NSE, r-Pfen, rBaEn, rSsEno, SEN, SjENO, Skeletal muscle enolase, SPM2, SsEno, SSO0913, streptococcal surface enolase, Tau-crystallin, tv-ENO1, tv-rENO1, XEP, yeast enolase

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.11 phosphopyruvate hydratase

Expression

Expression on EC 4.2.1.11 - phosphopyruvate hydratase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after 6 weeks of streptozotocin administration, the cardiac proteins from diabetic rats show the levels of alpha-enolase expression and protein tyrosine nitration are clearly increased, whereas the enolase activity and oxidation status are not significantly changed
alpha-enolase is consistently up-regulated from mild cognitive impairment to Alzheimer's disease
-
alpha-enolase is overexpressed at both mRNA and protein levels in pancreatic ductal adenocarcinoma cells
-
alpha-enolase is up-regulated in pancreatic ductal adenocarcinoma
-
ENOA expression is enhanced in diverse cancer cell types, e.g. cell surface ENOA in breast cancer cells, overview
-
enolase is induced by cold stress and cAMP but not by heat stress
-
enolase is induced under heat-shock treatment
-
enolase protein level decreases by more than 50% after 1.5-3 h exposure to hyperosmotic salt stress
-
In human follicular thyroid carcinoma cells, retinoic acid causes a decrease in ENOA levels that coincides with their reduced motility
-
levels of enolase mRNA are increased in encysting cells
lipopolysaccharide rapidly up-regulates ENO-1 cell-surface expression
-
PtrLOS2 expression in roots and stems is much higher than that in leaves under normal conditions, however, the expression of PtrLOS2 is upregulated in leaves, but downregulated in roots after cold treatments. The PtrLOS2 expression in stems is firstly up-regulated and then down-regulated after cold treatments. Abscisic acid treatment leads to upregulation of expression of PtrLOS2in leaves, while in stems and roots it is firstly downregulated and then followed by upregulation
the introduction or expression of enolase 2 double stranded RNA successfully silences the expression of enolase 2 at the levels of transcripts and proteins
-
tyrosine nitration inactivates enolase