4.2.1.11: phosphopyruvate hydratase

This is an abbreviated version!
For detailed information about phosphopyruvate hydratase, go to the full flat file.

Reaction

Synonyms

14-3-2 protein, 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydrolase, 2-phospho-D-glycerate hydrolyase, 2-phospho-D-glyceratehydrolyase, 2-phosphoglycerate dehydratase, 2-phosphoglycerate enolase, 2-phosphoglycerate hydrolase, 2-phosphoglycerate hydrolyase, 2-phosphoglyceric dehydratase, 2-phosphopyruvate hydrolyase, alpha,alpha-enolase, alpha-enolase, alpha-enolase 1, alpha-enolase 2, Alt a XI, beta,beta-enolase, beta-enolase, Cla h VI, Csenolase, cytotoxin B, EhENO, ENO, ENO-1, Eno-alpha, ENO-S, ENO1, Eno1p, Eno2, ENOA, EnoA I, EnoA1, ENOL, Enol-1, enolase, enolase 1, enolase 2, enolase alpha, enolase gamma, enolase S, enolase-1, enolase-alpha, enolase-beta, Enolase-phosphatase E1, enolase2p, Err2p, Err3p, gamma,gamma-enolase, gamma-enolase, hENO1, HLE1, human alpha-enolase, human neuron-specific enolase, hydratase, phosphoenolpyruvate, Laminin binding protein, Major allergen Alt a 11, MASA, MSE, Neural enolase, neuron specific enolase, neuron-specific enolase, neuronal enolase, NNE, Non-neural enolase, NSE, OSE1, p45, P46, Pfen, Pfeno, phosphoenolpyruvate enolase, phosphoenolpyruvate hydratase, Phosphopyruvate hydratase, plasminogen-binding alpha-enolase, R-NSE, r-Pfen, rBaEn, rSsEno, SEN, SjENO, Skeletal muscle enolase, SPM2, SsEno, SSO0913, streptococcal surface enolase, Tau-crystallin, tv-ENO1, tv-rENO1, XEP, yeast enolase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.11 phosphopyruvate hydratase

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Results	in table
6	Activating Compound
62303	AA Sequence
35	Application
1	CAS Registry Number
77	Cloned(Commentary)
3	Cofactor
29	Crystallization (Commentary)
16005	Disease/ Diagnostics
16	Expression
101	General Information
2	General Stability
2	IC50 Value
110	Inhibitors
13	kcat/KM [mM/s]
24	Ki Value [mM]
119	KM Value [mM]
174	Localization
105	Metals/Ions
164	Molecular Weight [Da]
128	Natural Substrates/ Products (Substrates)
315	Organism
27	Pathway
274	PDB ID
62	pH Optimum
8	pH Range
1	pH Stability
16	pI Value
8	Posttranslational Modification
53	Protein Variants
119	Purification (Commentary)
4	Reaction
2	Reaction Type
271	Reference
1	Renatured (Commentary)
204	Source Tissue
101	Specific Activity [micromol/min/mg]
7	Storage Stability
329	Substrates and Products (Substrate)
133	Subunits
314	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
4	Temperature Range [°C]
13	Temperature Stability [°C]
13	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 4.2.1.11 - phosphopyruvate hydratase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

acetylcholinesterase C-terminal peptide ARP

Oryctolagus cuniculus

-

the 26-amino-acid-long acetylcholinesterase C-terminal peptide ARP elevates activity of enolase in dose-dependent manner: 200 nM ARP by 7.1%, 600 nM ARP by 12.5%

697260

-

HCO3-

Geobacillus kaustophilus

Q5KVE7

Km about 50% increased in presence of sodium bicarbonate, crystallized enzyme structure complexed with HCO3- in its activated form

678268

phosphate

Streptococcus ratti

-

slight stimulation without F-

33630

additional information

3 entries

-

additional information

Solanum tuberosum

-

-

33619

-

additional information

Solanum tuberosum

-

-SH groups required for activity

33599

-

additional information

Spinacia oleracea

-

contains 23 half-cystines per mol of subunit

33619

-