4.2.1.11: phosphopyruvate hydratase This is an abbreviated version! For detailed information about phosphopyruvate hydratase, go to the full flat file .
Reaction
2-phospho-D-glycerate =
phosphoenolpyruvate +
H2O
Synonyms 14-3-2 protein, 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydrolase, 2-phospho-D-glycerate hydrolyase, 2-phospho-D-glyceratehydrolyase, 2-phosphoglycerate dehydratase, 2-phosphoglycerate enolase, 2-phosphoglycerate hydrolase, 2-phosphoglycerate hydrolyase, 2-phosphoglyceric dehydratase, 2-phosphopyruvate hydrolyase, alpha,alpha-enolase, alpha-enolase, alpha-enolase 1, alpha-enolase 2, Alt a XI, beta,beta-enolase, beta-enolase, Cla h VI, Csenolase, cytotoxin B, EhENO, ENO, ENO-1, Eno-alpha, ENO-S, ENO1, Eno1p, Eno2, ENOA, EnoA I, EnoA1, ENOL, Enol-1, enolase, enolase 1, enolase 2, enolase alpha, enolase gamma, enolase S, enolase-1, enolase-alpha, enolase-beta, Enolase-phosphatase E1, enolase2p, Err2p, Err3p, gamma,gamma-enolase, gamma-enolase, hENO1, HLE1, human alpha-enolase, human neuron-specific enolase, hydratase, phosphoenolpyruvate, Laminin binding protein, Major allergen Alt a 11, MASA, MSE, Neural enolase, neuron specific enolase, neuron-specific enolase, neuronal enolase, NNE, Non-neural enolase, NSE, OSE1, p45, P46, Pfen, Pfeno, phosphoenolpyruvate enolase, phosphoenolpyruvate hydratase, Phosphopyruvate hydratase, plasminogen-binding alpha-enolase, R-NSE, r-Pfen, rBaEn, rSsEno, SEN, SjENO, Skeletal muscle enolase, SPM2, SsEno, SSO0913, streptococcal surface enolase, Tau-crystallin, tv-ENO1, tv-rENO1, XEP, yeast enolase
ECTree
Localization
Localization on EC 4.2.1.11 - phosphopyruvate hydratase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
isozyme enolase 1
brenda
-
-
brenda
-
caudal flagellum
-
brenda
-
association of enolase with the food vacuole
brenda
-
-
brenda
-
up to 7% of enolase activity associated with mitochondria, targeting towards the mitochondrial outer membrane, affinity to the mitochondrial surface more than 10fold higher for Eno2p than for Eno1p
brenda
-
synaptic plasma membrane
brenda
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
brenda
-
brenda
-
-
-
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
-
secreted enzyme associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
-
brenda
-
putative ENOA translocation mechanism, overview
brenda
-
associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
brenda
-
-
-
brenda
-
secreted enzyme associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
brenda
-
-
-
brenda
-
-
brenda
-
associated to the external surface of the parasite
brenda
-
brenda
-
brenda
-
-
-
brenda
Streptomyces mutans
-
associated to the external surface of the parasite
brenda
Streptomyces pneumoniae
-
associated to the external surface of the parasite
brenda
-
-
brenda
-
associated to the external surface of the parasite
brenda
-
associated to the external surface of the parasite
brenda
-
brenda
-
-
brenda
-
brenda
-
-
-
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
-
-
brenda
-
-
-
brenda
partly localized inside the nucleus of sporozoites and schizonts, partly secreted, apex of the first generation of merozoites, relocalization inside sporozoites observed
brenda
-
partly localized inside the nucleus of sporozoites and schizonts, partly secreted, apex of the first generation of merozoites, relocalization inside sporozoites observed
-
brenda
-
-
brenda
-
-
brenda
-
-
-
brenda
-
-
brenda
-
-
brenda
surface-localization on merozoites determined by indirect immunofluorescence assay
brenda
Plasmodium yoeliie XL17
-
surface-localization on merozoites determined by indirect immunofluorescence assay
brenda
Plasmodium yoeliie XL17 17XL
-
surface-localization on merozoites determined by indirect immunofluorescence assay
-
brenda
-
brenda
-
brenda
low amounts of surface-exposed enolase, determined on viable pneumococci, monoclonal and polyconal antibodies used
brenda
-
-
brenda
-
brenda
-
-
-
brenda
-
isozyme enolase 2
brenda
-
brenda
-
as part of the degradosome complex
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
enzyme activity only in cytosolic fraction, inactive form detected in the microsomal fraction, membrane-association and localization at the external face of the plasma membrane determined by digitonin treatment and immunofluorescence studies
brenda
microsomal fraction analyzed
brenda
-
enzyme activity only in cytosolic fraction, inactive form detected in the microsomal fraction, membrane-association and localization at the external face of the plasma membrane determined by digitonin treatment and immunofluorescence studies
-
brenda
-
microsomal fraction analyzed
-
brenda
cytosolic fractions of myoblasts and myotubes, microtubule-association of alpha,alpha-enolase in undifferentiated myoblasts and in myotubes, also nuclear localization in myoblasts but not in myotubes determined, role of enolases in cytoskeletal dynamics during myoblast differentiation assumed
brenda
nuclear localization in myoblasts not detected, direct interaction with microtubules and tubulin during myoblast differentiation identified, role in cytoskeletal dynamics during myoblast differentiation assumed
brenda
-
-
brenda
-
brenda
-
-
-
brenda
-
-
brenda
-
-
brenda
small portion of enolase bound to vacuoles, in vitro stimulation of vacuole fusion determined
brenda
-
brenda
-
-
brenda
-
secreted enzyme associated to the external surface of the parasite
-
brenda
-
secreted enzyme
-
brenda
-
secreted enzyme
-
brenda
-
secreted enzyme
-
brenda
-
secreted enzyme
-
brenda
-
-
-
brenda
-
-
-
brenda
-
secreted enzyme
-
brenda
-
secreted enzyme
-
brenda
-
secreted enzyme
-
brenda
-
secreted enzyme
-
brenda
-
secreted enzyme
-
brenda
-
-
-
brenda
-
-
-
-
brenda
-
-
brenda
-
-
-
-
brenda
-
secreted enzyme associated to the external surface of the parasite
-
brenda
-
secreted enzyme
-
brenda
-
secreted enzyme
-
brenda
-
secreted enzyme
-
brenda
Streptomyces mutans
-
secreted enzyme
-
brenda
Streptomyces pneumoniae
-
secreted enzyme
-
brenda
-
secreted enzyme
-
brenda
-
secreted enzyme
-
brenda
-
-
brenda
-
-
-
-
brenda
-
-
brenda
-
-
-
-
brenda
-
-
brenda
-
-
brenda
-
in some human cancer cell lines
brenda
-
-
brenda
-
-
brenda
-
brenda
-
-
brenda
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
-
brenda
-
-
brenda
-
enolase does not contain a detectable secretion signal or membrane anchor region that can explain its membrane localization
brenda
-
enolase does not contain a detectable secretion signal or membrane anchor region that can explain its membrane localization
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
outer membrane vesicle
brenda
-
outer membrane vesicle
-
brenda
additional information
-
the enzyme is not exposed on the cell surface
-
brenda
additional information
-
the enzyme is not exposed on the cell surface
-
-
brenda
additional information
-
enolase as both an excretory/secretory product and a tegumental component of Clonorchis sinensis, immunohistochemical analysis
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface
-
brenda
additional information
-
enolase is specifically located inside vesicles containing densely packed fibrilar material
-
brenda
additional information
-
enolase is specifically located inside vesicles containing densely packed fibrilar material
-
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface
-
brenda
additional information
-
alpha-enolase is not detected in the nucleus
-
brenda
additional information
-
in breast, lung and pancreatic neoplasia, ENOA is localized on the surface of cancer cells, whereas in melanoma and nonsmall cell lung carcinoma cells it can also be secreted by exosomes
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface of Leishmania spp.
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface of Leishmania spp.
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface of Leishmania spp.
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface of Leishmania spp.
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface of Leishmania spp., no activity in microsomes. Enolase does not contain a detectable secretion signal or membrane anchor region that can explain its membrane localization
-
brenda
additional information
-
in asexual stages, enolase is predominantly present in soluble fraction, while in sexual stages it is mostly associated with particulate fraction
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface
-
brenda
additional information
-
enolase is found both in the secretome and in association with the surface
-
brenda
additional information
Streptomyces mutans
-
enolase is found both in the secretome and in association with the surface
-
brenda