4.2.1.11: phosphopyruvate hydratase

This is an abbreviated version!
For detailed information about phosphopyruvate hydratase, go to the full flat file.

Reaction

Synonyms

14-3-2 protein, 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydrolase, 2-phospho-D-glycerate hydrolyase, 2-phospho-D-glyceratehydrolyase, 2-phosphoglycerate dehydratase, 2-phosphoglycerate enolase, 2-phosphoglycerate hydrolase, 2-phosphoglycerate hydrolyase, 2-phosphoglyceric dehydratase, 2-phosphopyruvate hydrolyase, alpha,alpha-enolase, alpha-enolase, alpha-enolase 1, alpha-enolase 2, Alt a XI, beta,beta-enolase, beta-enolase, Cla h VI, Csenolase, cytotoxin B, EhENO, ENO, ENO-1, Eno-alpha, ENO-S, ENO1, Eno1p, Eno2, ENOA, EnoA I, EnoA1, ENOL, Enol-1, enolase, enolase 1, enolase 2, enolase alpha, enolase gamma, enolase S, enolase-1, enolase-alpha, enolase-beta, Enolase-phosphatase E1, enolase2p, Err2p, Err3p, gamma,gamma-enolase, gamma-enolase, hENO1, HLE1, human alpha-enolase, human neuron-specific enolase, hydratase, phosphoenolpyruvate, Laminin binding protein, Major allergen Alt a 11, MASA, MSE, Neural enolase, neuron specific enolase, neuron-specific enolase, neuronal enolase, NNE, Non-neural enolase, NSE, OSE1, p45, P46, Pfen, Pfeno, phosphoenolpyruvate enolase, phosphoenolpyruvate hydratase, Phosphopyruvate hydratase, plasminogen-binding alpha-enolase, R-NSE, r-Pfen, rBaEn, rSsEno, SEN, SjENO, Skeletal muscle enolase, SPM2, SsEno, SSO0913, streptococcal surface enolase, Tau-crystallin, tv-ENO1, tv-rENO1, XEP, yeast enolase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.11 phosphopyruvate hydratase

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Results	in table
6	Activating Compound
62303	AA Sequence
35	Application
1	CAS Registry Number
77	Cloned(Commentary)
3	Cofactor
29	Crystallization (Commentary)
16005	Disease/ Diagnostics
16	Expression
101	General Information
2	General Stability
2	IC50 Value
110	Inhibitors
13	kcat/KM [mM/s]
24	Ki Value [mM]
119	KM Value [mM]
174	Localization
105	Metals/Ions
164	Molecular Weight [Da]
128	Natural Substrates/ Products (Substrates)
315	Organism
27	Pathway
274	PDB ID
62	pH Optimum
8	pH Range
1	pH Stability
16	pI Value
8	Posttranslational Modification
53	Protein Variants
119	Purification (Commentary)
4	Reaction
2	Reaction Type
271	Reference
1	Renatured (Commentary)
204	Source Tissue
101	Specific Activity [micromol/min/mg]
7	Storage Stability
329	Substrates and Products (Substrate)
133	Subunits
314	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
4	Temperature Range [°C]
13	Temperature Stability [°C]
13	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 4.2.1.11 - phosphopyruvate hydratase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2,3-diketo-5-methylthiopentane 1-phosphate

2-hydroxy-3-keto-5-methylthiopent-1-ene 1-phosphate

3 entries

2,3-dioxo-5-methylthio-1-phosphopentane + 4 H+

3-hydroxy-5-methyl-thio-pent-2-en-1-yl-phosphate + H2O

Homo sapiens

-

-

666046

-

-

?

2-phospho-D-glycerate

?

4 entries

2-phospho-D-glycerate

phosphoenolpyruvate

Homo sapiens

-

-

703262

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

97 entries

phosphoenolpyruvate + H2O

2-phospho-D-glycerate

Bacillus anthracis

-

analysis of pathogenesis of Bacillus anthracis: binding of human plasminogen and laminin

696424

-

-

r

additional information

?

-

5 entries

2,3-diketo-5-methylthiopentane 1-phosphate

2-hydroxy-3-keto-5-methylthiopent-1-ene 1-phosphate

Bacillus subtilis

P37869

methionine salvage pathway

678268

-

-

?

2,3-diketo-5-methylthiopentane 1-phosphate

2-hydroxy-3-keto-5-methylthiopent-1-ene 1-phosphate

Bacillus subtilis 168

P37869

methionine salvage pathway

678268

-

-

?

2,3-diketo-5-methylthiopentane 1-phosphate

2-hydroxy-3-keto-5-methylthiopent-1-ene 1-phosphate

Geobacillus kaustophilus

Q5KVE7

methionine salvage pathway

678268

-

-

?

2-phospho-D-glycerate

?

Homo sapiens

-

the enzyme is a plasminogen binding protein

33626

-

-

?

2-phospho-D-glycerate

?

Mus musculus

-

beta,beta-enolase binds with high affinity the adjacent enzymes in the glycolytic pathway (pyruvate kinase and phosphoglycerate mutase), beta,beta-enolase binds with high affinity sarcomeric troponin but not actin and tropomyosin

33625

-

-

?

2-phospho-D-glycerate

?

Saccharomyces cerevisiae

-

enzyme of glycolysis

33599

-

-

?

2-phospho-D-glycerate

?

Turbatrix aceti

-

age-related changes in the properties of the enzyme

33610

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Aeromonas hydrophila

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Anisakis simplex

Q8MU59

-

681750

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Archaeoglobus fulgidus

-

the enzyme is involved in the modified Embden-Meyerhof pathway

721449

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Bacteroides fragilis

Q8KNX9

-

666254

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Bacteroides fragilis YCH46

Q8KNX9

-

666254

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Bifidobacterium animalis subsp. lactis

Q45RT9

-

705569

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Bifidobacterium animalis subsp. lactis BI07

Q45RT9

-

705569

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Bifidobacterium bifidum

-

-

705569

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Bifidobacterium bifidum S16

-

-

705569

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Bifidobacterium breve

-

-

705569

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Bifidobacterium breve BBSF

-

-

705569

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Bifidobacterium longum

-

-

705569

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Borreliella burgdorferi

-

-

729820, 730683

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Borreliella burgdorferi B31

-

-

729820

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Borreliella burgdorferi B31-MI-16

-

-

730683

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Brucella abortus

Q2YPV0

-

716180

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Brucella abortus A19

Q2YPV0

-

716180

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Candida albicans

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Citrus trifoliata

D7NHW9

-

714394

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Clonorchis sinensis

-

-

716155

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Curvularia lunata

Q96VP4

-

681072

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Echinostoma caproni

A1J8J9

-

679701

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Echinostoma caproni

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Eimeria tenella

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Eimeria tenella

Q967Y8

-

674072

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Eimeria tenella PaPt36

Q967Y8

-

674072

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Entamoeba histolytica

-

-

706464

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Entamoeba histolytica

C4LXE8

-

713621

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Escherichia coli

P0A6P9

-

681381

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Fasciola hepatica

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Giardia intestinalis

-

-

714875, 730352

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Haemonchus contortus

-

-

730926

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Homo sapiens

-

-

665313, 665841, 666023, 666046, 702856, 703739, 704073, 706933

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Klebsiella pneumoniae

-

-

664971

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Lactiplantibacillus plantarum

-

-

730339

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Lactiplantibacillus plantarum

-

-

705532

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Lactiplantibacillus plantarum LM3

-

-

730339

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Lactiplantibacillus plantarum LM3

-

-

705532

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Lactobacillus crispatus

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Lactobacillus gasseri

Q042F4

-

729739

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leishmania braziliensis

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leishmania chagasi

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leishmania donovani

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leishmania infantum

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leishmania major

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leishmania mexicana

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leishmania mexicana

Q3HL75

-

679699, 682238

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leishmania mexicana

-

-

682238

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leishmania mexicana AZV

Q3HL75

-

679699, 682238

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leptospira interrogans

-

-

730753

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leptospira interrogans 56601

-

-

730753

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leuconostoc mesenteroides

Q1ET73

-

679893

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Leuconostoc mesenteroides B-512FMCM

Q1ET73

-

679893

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Mus musculus

-

-

714692

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Mus musculus

P17182, P21550

-

678431

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Plasmodium falciparum

-

-

664835, 705479, 714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Plasmodium falciparum

Q8IJN7

-

680144

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Plasmodium falciparum

Q27727

-

679767

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Plasmodium falciparum NF54

-

-

664835

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Plasmodium yoeliie XL17

-

-

680144

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Plasmodium yoeliie XL17 17XL

-

-

680144

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Pyrococcus furiosus

Q9UWJ5

the enzyme probably functions in sugar fermentation pathway

721409

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Saccharomyces cerevisiae

-

-

729837, 731032

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Saccharomyces cerevisiae

-

-

680008, 703739, 706611

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Saccharomyces cerevisiae

P00924, P00925

-

680645

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Saccharomyces cerevisiae

P00924

-

666065, 679807

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Saccharomyces cerevisiae

-

-

679807

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Saccharomyces cerevisiae

P00924

-

680369, 680944

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Saccharomyces cerevisiae

-

-

680944

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Saccharomyces cerevisiae BY4743

-

-

731032

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Salmonella enterica

-

-

729342

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Schistosoma bovis

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Schistosoma japonicum

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Schistosoma japonicum

Q5DDV5

-

716427

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Staphylococcus aureus

-

-

731021

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Staphylococcus aureus

O69174

-

666252

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Staphylococcus aureus RN4220

-

-

731021

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Staphylococcus aureus Wood 46

O69174

-

666252

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Steinernema glaseri

B8Q027

-

730353

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Steinernema glaseri NC

B8Q027

-

730353

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Streptococcus pneumoniae

Q97QS2

-

666033, 681786

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Streptococcus pneumoniae

-

-

681786

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Streptococcus pyogenes

-

-

651496, 714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Streptococcus suis

K7N5M7

-

730857

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Streptococcus suis

-

analysis of pathogenesis of Streptococcus suis: rSsEno binds to fibronectin and plasminogen

700041

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Streptomyces mutans

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Streptomyces pneumoniae

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Theileria annulata

E9NJD0

-

730374

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Trichinella spiralis

-

-

666529

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Trichinella spiralis ISS413

-

-

666529

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Trichomonas vaginalis

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Trypanosoma brucei

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Trypanosoma brucei

Q9NDH8

-

679787

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Trypanosoma cruzi

-

-

714875

-

-

r

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Vibrio parahaemolyticus

W6ABG9

-

729079

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Vibrio parahaemolyticus ATCC 33847

W6ABG9

-

729079

-

-

?

2-phospho-D-glycerate

phosphoenolpyruvate + H2O

Xanthomonas oryzae

Q5H0Y0

-

701951

-

-

r

additional information

?

-

Borreliella burgdorferi

-

plasminogen bound to recombinant enolase can be converted to active plasmin

730683

-

-

?

additional information

?

-

Borreliella burgdorferi B31-MI-16

-

plasminogen bound to recombinant enolase can be converted to active plasmin

730683

-

-

?

additional information

?

-

Clonorchis sinensis

-

enolase shows plasminogen-binding activity

716155

-

-

?

additional information

?

-

Entamoeba histolytica

-

enolase acts as a DNA methyltransferase 2 inhibitor. Enolase interacts with Ehmeth, and modulates its activity under conditions of glucose starvation inhibiting the binding of Ehmeth and human DNA methyltransferase 2 to Entamoeba histolytica MRS2 DNA

706464

-

-

?

additional information

?

-

Homo sapiens

-

ENOA has C-terminal lysines predominantly responsible for plasminogen activation, interaction of the plasminogen lysinebinding sites with ENOA is dependent upon recognition of ENOA C-terminal lysines K420, K422 and K434, and also K256

714970

-

-

?