4.1.1.33: diphosphomevalonate decarboxylase This is an abbreviated version! For detailed information about diphosphomevalonate decarboxylase, go to the full flat file .
Reaction
ATP +
(R)-5-diphosphomevalonate =
ADP +
phosphate +
isopentenyl diphosphate +
CO2
Synonyms 5-Pyrophosphomevalonate decarboxylase, Decarboxylase, pyrophosphomevalonate, diphosphomevalonate decarboxylase, diphosphomevalonte decarboxylase, DMD, DPM-DC, Fjoh_1389, MDD, MDP, Mevalonate (diphospho)decarboxylase, mevalonate 5'-diphosphate decarboxylase, Mevalonate 5-diphosphate decarboxylase, mevalonate diphosphate decarboxylase, mevalonate diphospho decarboxylase, Mevalonate pyrophosphate decarboxylase, mevalonate pyrophosphate decraboxylase, Mevalonate-5-pyrophosphate decarboxylase, More, MPD, MvaD, MVD, phosphomevalonate decarboxylase, PMD, Pyrophosphomevalonate decarboxylase, Pyrophosphomevalonic acid decarboxylase, ScMDD, ScMDD1, ScMDD2, scMVD, SSO2989
ECTree
Source Tissue
Source Tissue on EC 4.1.1.33 - diphosphomevalonate decarboxylase
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most highly expressed in female flowers
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located in cytoplasm of laticifers
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B16F10
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the expression level in latex decreases progressively from the first, second, fourth, and third leaf stories of young shoots
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low activity
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activity changes considerably under different dietary situations
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epithelium
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the relative amount of mevalonate pyrophosphate decarboxylase in kidney is higher than in rats and similar to in mice
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high activity
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low activity
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in female rat the activity is lower than in male rat
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seasonal variations in activity, maximal activity in hot summer months, in the cold winter months the activity cannot be detected
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constitutively expressed in roots, stems and leaves
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strongly expressed in leaves
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mevalonate pyrophosphate decarboxylase in the liver is higher than in other tissues
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high activity, marked induction of MDP in liver by provastatin is responsible for the tissue-specific effect of pravastatin
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in female rats the activity is higher than in male animals
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decrease in activity when rats are fasted, fed with a diet containing 2% cholesterol or made diabetic, increase in activity when the animals are fed with a diet containing 3% cholestyramine
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lower activity of mevalonate-diphosphate decarboxylase is responsible for the reduced cholesterol biosynthesis in the liver of stroke-prone spontaneously hypertensive rat
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from animals fed a diet containing cholestyramine and pravastin
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highest expression in liver
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low activity
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low level of transcript
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low level of transcript
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transcript level is 54fold higher than in mycelium
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transcript level is 54fold higher than in mycelium
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constitutively expressed in roots, stems and leaves
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hairy root
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constitutively expressed in roots, stems and leaves
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