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Literature summary for 4.1.1.33 extracted from

  • Qiu, Y.; Li, D.
    Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs (2006), Biochim. Biophys. Acta, 1760, 1080-1087.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-fluoromevalonate 5-diphosphate irreversible inhibitor Rattus norvegicus
geranyl diphosphate
-
Rattus norvegicus
P'-geranyl 2-fluoromevalonate 5-diphosphate irreversible inhibitor Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00053
-
ATP
-
Rattus norvegicus
0.036
-
5-diphosphomevalonate
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
Rattus norvegicus 5777
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-diphosphomevalonate
-
Rattus norvegicus ADP + phosphate + isopentenyl diphosphate + CO2
-
?

Synonyms

Synonyms Comment Organism
MDD
-
Rattus norvegicus
Mevalonate 5-diphosphate decarboxylase
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00302
-
2-fluoromevalonate 5-diphosphate in 100 mM Tris buffer, pH 7.5, at 25°C Rattus norvegicus
0.0046
-
P'-geranyl 2-fluoromevalonate 5-diphosphate in 100 mM Tris buffer, pH 7.5, at 25°C Rattus norvegicus