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(2E)-3,7-dimethylocta-2,6-dien-1-yl 2-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)ethyl diphosphate
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(2E)-3,7-dimethylocta-2,6-dien-1-yl 4-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)butyl diphosphate
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(R)-6-fluoromevalonate diphosphate
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(R,S)-diphosphoglycolyl proline
competitive inhibitor
1-(diphosphenyloxy)-3,4-dimethylpentan-3-ol
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1-(diphosphenyloxy)-3-methylpentan-3-ol
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1-(diphosphenyloxy)-5-fluoro-3-methylpentan-3-ol
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2,2-difluoromevalonate 5-diphosphate
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2-fluoromevalonate 5-diphosphate
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irreversible inhibitor
24S-hydroxycholesterol
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down-regulates the expression
3-ethyl-2-fluoro-3,5-dihydroxy-pentanate 5-diphosphate
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4-(diphosphenyloxy)-2-methylbutan-2-ol
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4-(diphosphenyloxy)-2-phenylbutan-2-ol
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5,5'-dithiobis(2-nitrobenzoate)
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presence of substrate ATP or mevalonate 5-diphosphate protects effectively against inactivation
6-fluoromevalonate 5-diphosphate
competitive inhibitor with respect to 5-diphosphomevalonate
6-fluoromevalonate diphosphate
6-fluoromevalonate monophosphate
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strong inhibition
adenosine 5'-O-(3-thiotriphosphate)
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arsenite-2,3-dimercapto-1-propanol
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diphosphoglycolyl proline
competitive inhibitor with respect to 5-diphosphomevalonate
diphosphoglycolyl-L-proline
competitive
DTNB
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10 mM, 60% inhibition
eriochrome black A
competitive with regard to (R)-5-diphosphomevalonate, inhibits both enzymatic activity and bacterial growth
Eriochrome Black T
competitive with regard to (R)-5-diphosphomevalonate, inhibits both enzymatic activity and bacterial growth
Eriochrome blue black
competitive with regard to (R)-5-diphosphomevalonate, inhibits both enzymatic activity and bacterial growth
iodoacetic acid
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10 mM, 15% inhibition
methylmethanethiosulfonate
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presence of substrate ATP or mevalonate 5-diphosphate protects effectively against inactivation
mevalonate
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mixed inhibition
mevalonate 5-phosphate
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mixed inhibition
NEM
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10 mM, 40% inhibition
P'-geranyl 2-fluoromevalonate 5-diphosphate
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irreversible inhibitor
P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
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p-chloromercuribenzene sulfonic acid
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10 mM, 50% inhibition
Phenylglyoxal
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inactivation follows pseudo-first-order kinetics
phloroglucinol carboxylic acid
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triflouromevalonate diposphate
molecular dynamics simulation for the inhibitor bound complex
additional information
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probucol decreases mevalonate pyrophosphate decarboxylase in the rat liver
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6-fluoromevalonate diphosphate
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negligible inhibition
6-fluoromevalonate diphosphate
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forms stable hydrogen bonds with residues Arg144, Arg193, Lys21, Ser107, and Tyr18, as well as stable hydrophobic interactions with Tyr18, Trp19, and Met196
6-fluoromevalonate diphosphate
competitive
citrate
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inhibits below pH 4.8
diphosphoglycolylproline
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diphosphoglycolylproline
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