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4.1.1.33: diphosphomevalonate decarboxylase

This is an abbreviated version!
For detailed information about diphosphomevalonate decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.33

Reaction

ATP
+
(R)-5-diphosphomevalonate
=
ADP
+
phosphate
+
isopentenyl diphosphate
+
CO2

Synonyms

5-Pyrophosphomevalonate decarboxylase, Decarboxylase, pyrophosphomevalonate, diphosphomevalonate decarboxylase, diphosphomevalonte decarboxylase, DMD, DPM-DC, Fjoh_1389, MDD, MDP, Mevalonate (diphospho)decarboxylase, mevalonate 5'-diphosphate decarboxylase, Mevalonate 5-diphosphate decarboxylase, mevalonate diphosphate decarboxylase, mevalonate diphospho decarboxylase, Mevalonate pyrophosphate decarboxylase, mevalonate pyrophosphate decraboxylase, Mevalonate-5-pyrophosphate decarboxylase, More, MPD, MvaD, MVD, phosphomevalonate decarboxylase, PMD, Pyrophosphomevalonate decarboxylase, Pyrophosphomevalonic acid decarboxylase, ScMDD, ScMDD1, ScMDD2, scMVD, SSO2989

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.33 diphosphomevalonate decarboxylase

Inhibitors

Inhibitors on EC 4.1.1.33 - diphosphomevalonate decarboxylase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E)-3,7-dimethylocta-2,6-dien-1-yl 2-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)ethyl diphosphate
-
-
(2E)-3,7-dimethylocta-2,6-dien-1-yl 4-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)butyl diphosphate
-
-
(R)-6-fluoromevalonate diphosphate
-
(R,S)-diphosphoglycolyl proline
competitive inhibitor
1-(diphosphenyloxy)-3,4-dimethylpentan-3-ol
-
-
1-(diphosphenyloxy)-3-methylpentan-3-ol
-
-
1-(diphosphenyloxy)-5-fluoro-3-methylpentan-3-ol
-
-
2,2-difluoromevalonate 5-diphosphate
-
-
2-fluoromevalonate 5-diphosphate
-
irreversible inhibitor
24S-hydroxycholesterol
-
down-regulates the expression
3-ethyl-2-fluoro-3,5-dihydroxy-pentanate 5-diphosphate
-
-
4-(diphosphenyloxy)-2-methylbutan-2-ol
-
-
4-(diphosphenyloxy)-2-phenylbutan-2-ol
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
presence of substrate ATP or mevalonate 5-diphosphate protects effectively against inactivation
6-fluoromevalonate 5-diphosphate
competitive inhibitor with respect to 5-diphosphomevalonate
6-fluoromevalonate diphosphate
6-fluoromevalonate monophosphate
-
strong inhibition
adenosine 5'-O-(3-thiotriphosphate)
-
-
arsenite-2,3-dimercapto-1-propanol
-
-
Cd2+
-
-
citrate
Diamide
-
-
diphosphoglycolyl proline
competitive inhibitor with respect to 5-diphosphomevalonate
diphosphoglycolyl-L-proline
competitive
diphosphoglycolylproline
DTNB
-
10 mM, 60% inhibition
eriochrome black A
competitive with regard to (R)-5-diphosphomevalonate, inhibits both enzymatic activity and bacterial growth
Eriochrome Black T
competitive with regard to (R)-5-diphosphomevalonate, inhibits both enzymatic activity and bacterial growth
Eriochrome blue black
competitive with regard to (R)-5-diphosphomevalonate, inhibits both enzymatic activity and bacterial growth
ferulate
-
-
geranyl diphosphate
-
-
iodoacetic acid
-
10 mM, 15% inhibition
methylmethanethiosulfonate
-
presence of substrate ATP or mevalonate 5-diphosphate protects effectively against inactivation
mevalonate
-
mixed inhibition
mevalonate 5-phosphate
-
mixed inhibition
MgADP-
-
-
Mn2+
-
-
NEM
-
10 mM, 40% inhibition
P'-geranyl 2-fluoromevalonate 5-diphosphate
-
irreversible inhibitor
P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
-
-
p-chloromercuribenzene sulfonic acid
-
10 mM, 50% inhibition
p-coumarate
-
-
Phenylarsine oxide
-
-
Phenylglyoxal
-
inactivation follows pseudo-first-order kinetics
phloroglucinol carboxylic acid
-
-
phosphate
-
-
Phthalate
-
-
protocatechuate
-
-
Resorcyclic acid
-
-
triflouromevalonate diposphate
molecular dynamics simulation for the inhibitor bound complex
Zn2+
-
-
additional information
-
probucol decreases mevalonate pyrophosphate decarboxylase in the rat liver
-