3.6.1.15: nucleoside-triphosphate phosphatase This is an abbreviated version! For detailed information about nucleoside-triphosphate phosphatase, go to the full flat file .
Reaction
a nucleoside triphosphate +
H2O =
a nucleoside diphosphate +
phosphate
Synonyms AAA-type nucleoside triphosphatase phosphohydrolase, ankyrin repeat-rich membrane spanning protein, cell division control protein Cdc48, DEAH-box Prp22 protein, DEAH-box splicing factor Prp22, DExH-Box NTPase, DR_0079, germ-cell-specific leucine-rich repeat protein, GP086L protein, HCR-NTPase, HrpB, HrpB NTPase, human cancer-related nucleoside triphosphatase, KAP NTPase, Kidins220, kinase D interacting substance of 220 kDa, LDBPK_100150, LdNTPDase2, LINF_150005200, LiNTPDase1, LMXM_10_0170, LMXM_15_0030, LmxNTPDase1, LmxNTPDase2, M86L protein, MC100R, Mg2+-dependent NTPase, More, Msm0858, NALP14, non-specific nucleoside triphosphatase, nonstructural protein 13, NPH I, NS3, NS3 protein, NS3FL, nsp13, NTP1, NTP3, NTPase, NTPase 1, NTPase 2, NTPase-I, NTPase-II, NTPase/helicase, NTPDase, NTPDase 1, NTPDase1, NTPDase2, nucleic acid-independent nucleoside triphosphatase, nucleoside 5-triphosphatase, nucleoside triphosphatase, nucleoside triphosphatase (NTPase)/helicase, nucleoside triphosphate diphospho-hydrolase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate diphosphohydrolase 1, nucleoside triphosphate hydrolase, nucleoside triphosphate hydrolases I, nucleoside triphosphate hydrolases II, nucleoside triphosphate phosphohydrolase, nucleoside triphosphate phosphohydrolase I, nucleoside-5-triphosphate phosphohydrolase, nucleoside-triphosphatase 1, nucleoside-triphosphatase 2, nucleotide 5'-triphosphatase, P-loop NTPase, phosphatase, nucleoside tri-, PilB, PilT, PilU, polypeptide p41, protein NS3, PVA coat protein, PVA CP, PVx coat protein, PVX CP, Rad55B, RNA-dependent nucleoside triphosphatase, SHVp41, Sso0909, T4P motor protein, type IV pilus motor protein, YtkD
ECTree
Natural Substrates Products
Natural Substrates Products on EC 3.6.1.15 - nucleoside-triphosphate phosphatase
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ADP + H2O
AMP + phosphate
ATP + H2O
ADP + phosphate
CDP + H2O
CMP + phosphate
CTP + H2O
CDP + phosphate
dADP + H2O
dAMP + phosphate
relative substrate activity toward a variety of nucleoside di- and triphosphate substrates
-
-
?
dATP + H2O
dADP + phosphate
dCDP + H2O
dCMP + phosphate
next most preferred substrates with a relative activity of <50% compared to CDP, activity at the site of the phosphodiester bond corroborated using 31P NMR spectroscopy
-
-
?
dCTP + H2O
dCDP + phosphate
dGDP + H2O
dGMP + phosphate
relative substrate activity toward a variety of nucleoside di- and triphosphate substrates
-
-
?
dGTP + H2O
dGDP + phosphate
dITP + H2O
dTDP + phosphate
-
-
-
?
dTTP + H2O
dTDP + phosphate
-
-
-
?
dUTP + H2O
dUDP + phosphate
-
-
-
-
?
GDP + H2O
GMP + phosphate
GTP + H2O
GDP + phosphate
IDP + H2O
IMP + phosphate
ITP + H2O
IDP + phosphate
NTP + H2O
NDP + phosphate
RNA + H2O
?
-
removal of the gamma-phosphate
-
-
?
TDP + H2O
TMP + phosphate
relative substrate activity toward a variety of nucleoside di- and triphosphate substrates
-
-
?
TTP + H2O
TDP + phosphate
UDP + H2O
UMP + phosphate
UTP + H2O
UDP + phosphate
XTP + H2O
XDP + phosphate
-
0.5 mM, 40% relative activity compared to CTP
-
-
?
additional information
?
-
ADP + H2O
AMP + phosphate
-
0.5 mM, 25% relative activity towards ADP compared to CTP, no activity towards AMP
-
-
?
ADP + H2O
AMP + phosphate
relative substrate activity toward a variety of nucleoside di- and triphosphate substrates
-
-
?
ADP + H2O
AMP + phosphate
-
-
-
-
?
ADP + H2O
AMP + phosphate
-
-
-
ir
ADP + H2O
AMP + phosphate
-
-
-
ir
ADP + H2O
AMP + phosphate
-
-
-
-
ir
ADP + H2O
AMP + phosphate
-
-
-
ir
ADP + H2O
AMP + phosphate
-
-
-
ir
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
0.5 mM, 32% relative activity compared to CTP
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
relative substrate activity toward a variety of nucleoside di- and triphosphate substrates
-
-
?
ATP + H2O
ADP + phosphate
-
ATPase activity
-
-
?
ATP + H2O
ADP + phosphate
-
NTPase activity
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
NTPase activity
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
NTPase activity
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
ir
ATP + H2O
ADP + phosphate
-
-
-
ir
ATP + H2O
ADP + phosphate
-
-
-
-
ir
ATP + H2O
ADP + phosphate
-
-
-
ir
ATP + H2O
ADP + phosphate
-
-
-
ir
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
-
-
?
ATP + H2O
ADP + phosphate
-
NTPase activity
-
-
?
CDP + H2O
CMP + phosphate
-
0.5 mM, 41% relative activity towards CDP, no activity towards CMP
-
-
?
CDP + H2O
CMP + phosphate
first nudix hydrolase observed to have a marked preference for CDP and CTP, activity at the site of the phosphodiester bond corroborated using 31P NMR spectroscopy, nucleophilic substitution at the beta-phosphorus
-
-
?
CTP + H2O
CDP + phosphate
-
0.5 mM, 100% relative activity
-
-
?
CTP + H2O
CDP + phosphate
-
-
-
-
?
CTP + H2O
CDP + phosphate
first nudix hydrolase observed to have a marked preference for CDP and CTP, activity at the site of the phosphodiester bond corroborated using 31P NMR spectroscopy, nucleophilic substitution at the beta-phosphorus
-
-
?
CTP + H2O
CDP + phosphate
-
-
-
?
CTP + H2O
CDP + phosphate
-
-
-
-
?
CTP + H2O
CDP + phosphate
-
-
-
-
?
CTP + H2O
CDP + phosphate
-
-
-
?
CTP + H2O
CDP + phosphate
-
-
-
?
CTP + H2O
CDP + phosphate
-
-
-
?
dATP + H2O
dADP + phosphate
-
-
-
-
?
dATP + H2O
dADP + phosphate
relative substrate activity toward a variety of nucleoside di- and triphosphate substrates
-
-
?
dATP + H2O
dADP + phosphate
-
-
-
?
dCTP + H2O
dCDP + phosphate
-
-
-
-
?
dCTP + H2O
dCDP + phosphate
next most preferred substrates with a relative activity of <50% compared to CDP, activity at the site of the phosphodiester bond corroborated using 31P NMR spectroscopy
-
-
?
dCTP + H2O
dCDP + phosphate
-
-
-
?
dGTP + H2O
dGDP + phosphate
-
-
-
-
?
dGTP + H2O
dGDP + phosphate
relative substrate activity toward a variety of nucleoside di- and triphosphate substrates
-
-
?
dGTP + H2O
dGDP + phosphate
best substrate
-
-
?
GDP + H2O
GMP + phosphate
-
0.5 mM, 19% relative activity towards GDP compared to CTP, no activity towards GMP
-
-
?
GDP + H2O
GMP + phosphate
relatively low substrate activity
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
0.5 mM, 30% relative activity compared to CTP
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
relatively low substrate activity
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
GTP + H2O
GDP + phosphate
-
-
-
?
IDP + H2O
IMP + phosphate
-
0.5 mM, 41% relative activity towards IDP compared to CTP, 5.3% relative activity towards IMP compared to CTP
-
-
?
IDP + H2O
IMP + phosphate
activity at the site of the phosphodiester bond corroborated using 31P NMR spectroscopy, low substrate activity
-
-
?
ITP + H2O
IDP + phosphate
-
0.5 mM, 58% relative activity compared to CTP
-
-
?
ITP + H2O
IDP + phosphate
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
NTPase activity
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
Magnetococcus sp.
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
NTP + H2O
NDP + phosphate
-
-
-
-
?
TTP + H2O
TDP + phosphate
relative substrate activity toward a variety of nucleoside di- and triphosphate substrates
-
-
?
TTP + H2O
TDP + phosphate
-
-
-
-
?
UDP + H2O
UMP + phosphate
-
0.5 mM, 32% relative activity compared to CTP, 8.2% relative activity towards UMP compared to CTP
-
-
?
UDP + H2O
UMP + phosphate
relative low substrate activity
-
-
?
UTP + H2O
UDP + phosphate
-
0.5 mM, 66% relative activity compared to CTP
-
-
?
UTP + H2O
UDP + phosphate
-
-
-
-
?
UTP + H2O
UDP + phosphate
-
-
-
-
?
UTP + H2O
UDP + phosphate
relative low substrate activity
-
-
?
UTP + H2O
UDP + phosphate
-
-
-
?
UTP + H2O
UDP + phosphate
-
-
-
-
?
UTP + H2O
UDP + phosphate
-
-
-
-
?
UTP + H2O
UDP + phosphate
-
-
-
?
UTP + H2O
UDP + phosphate
-
-
-
?
UTP + H2O
UDP + phosphate
-
-
-
?
additional information
?
-
-
the viral NS3 protein, i.e. NS3FL, and its N-terminal truncated version ntNS3, recombinantly expressed in Escherichia coli, contain specific polynucleotide-stimulated NTPase acitivity, the enzyme activity is essential for viral replication
-
-
?
additional information
?
-
-
the viral NS3 protein, i.e. NS3FL, and its N-terminal truncated version ntNS3, recombinantly expressed in Escherichia coli, contain specific polynucleotide-stimulated NTPase acitivity, the enzyme activity is essential for viral replication
-
-
?
additional information
?
-
-
the enzyme is involved in RNA replication and capping, overview
-
-
?
additional information
?
-
-
multifunctional protein, possessing protease, NTPase and helicase activities. These activities are essential for the virus life cycle
-
-
?
additional information
?
-
-
the coat protein of the plant virus exhibits NTPase activity, the coat proteins are involved in different stages of the viral life cycle such as virion assembyl, replication, movement, vector transmission, and regulation of host defense response
-
-
?
additional information
?
-
-
the coat protein of the plant virus exhibits NTPase activity, the coat proteins are involved in different stages of the viral life cycle such as virion assembyl, replication, movement, vector transmission, and regulation of host defense response
-
-
?
additional information
?
-
Sso0909 is an orthologue of the eukaryotic endosomal sorting complex required for transport, ESCRT, ATPase Vps4, i.e. vacular protein sorting 4. Sso0909 is not involved in a cellular protection mechanism, but is required during normal cell growth
-
-
?
additional information
?
-
-
Sso0909 is an orthologue of the eukaryotic endosomal sorting complex required for transport, ESCRT, ATPase Vps4, i.e. vacular protein sorting 4. Sso0909 is not involved in a cellular protection mechanism, but is required during normal cell growth
-
-
?
additional information
?
-
-
the N-terminal AAA+ ATPase domains of Orc1/Cdc6 proteins show DNA-binding activities and functional interactions with other Cdc6 proteins, on duplex DNA substrates derived from the origins of Sulfolobus solfataricus, overview. ATPase domain of Cdc6-2 retains both DNA-binding activity and regulating effect on that of Cdc6-3 at the origin, overview
-
-
?
additional information
?
-
-
the DEAH-box splicing factor Prp22 is important in the second transesterification step of pre-mRNA splicing and is essential for release of mature mRNA from the splicosome
-
-
?