Cloned (Comment) | Organism |
---|---|
enzyme expression in Escherichia coli | Dengue virus |
enzyme expression in Escherichia coli | Japanese encephalitis virus |
expression of NS3 in Escherichia coli | Hepacivirus C |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-beta-D-ribofuranosyl-1H-benzotriazole | - |
Dengue virus | |
1-beta-D-ribofuranosyl-1H-benzotriazole | - |
Hepacivirus C | |
1-beta-D-ribofuranosyl-1H-benzotriazole | - |
Japanese encephalitis virus | |
1-beta-D-ribofuranosyl-1H-benzotriazole | - |
West Nile virus | |
1-beta-D-ribofuranosyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
1-beta-D-ribofuranosyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
1-beta-D-ribofuranosyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
1-beta-D-ribofuranosyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
1-beta-D-ribofuranosyl-4,5,6,7-tetramethyl-1H-benzotriazole | - |
Dengue virus | |
1-beta-D-ribofuranosyl-4,5,6,7-tetramethyl-1H-benzotriazole | - |
Hepacivirus C | |
1-beta-D-ribofuranosyl-4,5,6,7-tetramethyl-1H-benzotriazole | - |
Japanese encephalitis virus | |
1-beta-D-ribofuranosyl-4,5,6,7-tetramethyl-1H-benzotriazole | - |
West Nile virus | |
1-beta-D-ribofuranosyl-4,7-dibromo-1H-benzotriazole | - |
Dengue virus | |
1-beta-D-ribofuranosyl-4,7-dibromo-1H-benzotriazole | - |
Hepacivirus C | |
1-beta-D-ribofuranosyl-4,7-dibromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
1-beta-D-ribofuranosyl-4,7-dibromo-1H-benzotriazole | - |
West Nile virus | |
1-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
1-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
1-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
1-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
1-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
1-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
1-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
1-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
1-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
1-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
1-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
1-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
1-methyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
1-methyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
1-methyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
1-methyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
1-propyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
1-propyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
1-propyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
1-propyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
2-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
2-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
2-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
2-chloroethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
2-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
2-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
2-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
2-ethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
2-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
2-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
2-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
2-hydroxyethyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
2-methyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
2-methyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
2-methyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
2-methyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
2-propyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
2-propyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
2-propyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
2-propyl-4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
4,5,6,7-tetrabromo-1H-benzotriazole | - |
Dengue virus | |
4,5,6,7-tetrabromo-1H-benzotriazole | - |
Hepacivirus C | |
4,5,6,7-tetrabromo-1H-benzotriazole | - |
Japanese encephalitis virus | |
4,5,6,7-tetrabromo-1H-benzotriazole | - |
West Nile virus | |
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzotriazole | - |
Dengue virus | |
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzotriazole | - |
Hepacivirus C | |
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzotriazole | - |
Japanese encephalitis virus | |
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzotriazole | - |
West Nile virus | |
additional information | inhibitor cytotoxicity study, overview | Dengue virus | |
additional information | inhibitor cytotoxicity study, overview | Hepacivirus C | |
additional information | inhibitor cytotoxicity study, overview | Japanese encephalitis virus | |
additional information | inhibitor cytotoxicity study, overview | West Nile virus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
NaCl | stimulates | Dengue virus | |
NaCl | stimulates | Hepacivirus C | |
NaCl | stimulates | West Nile virus | |
NaCl | stimulates | Japanese encephalitis virus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Dengue virus | NTPase activity | ADP + phosphate | - |
? | |
ATP + H2O | Hepacivirus C | NTPase activity | ADP + phosphate | - |
? | |
ATP + H2O | West Nile virus | NTPase activity | ADP + phosphate | - |
? | |
ATP + H2O | Japanese encephalitis virus | NTPase activity | ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dengue virus | - |
i.e. DENV | - |
Hepacivirus C | - |
i.e. HCV | - |
Japanese encephalitis virus | - |
i.e. JEV | - |
West Nile virus | - |
i.e. WNV | - |
Purification (Comment) | Organism |
---|---|
native enzyme from virus Vero E6 cell culture medium by affinity chromatography, ultrafiltration, and gel filtration | West Nile virus |
recombinant enzyme from Escherichia coli | Dengue virus |
recombinant enzyme from Escherichia coli | Japanese encephalitis virus |
recombinant NS3 from Escherichia coli | Hepacivirus C |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | virus from Vero E6 cell culture, excreted to the medium | West Nile virus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | NTPase activity | Dengue virus | ADP + phosphate | - |
? | |
ATP + H2O | NTPase activity | Hepacivirus C | ADP + phosphate | - |
? | |
ATP + H2O | NTPase activity | West Nile virus | ADP + phosphate | - |
? | |
ATP + H2O | NTPase activity | Japanese encephalitis virus | ADP + phosphate | - |
? | |
additional information | multifunctional enzyme showing nucleoside triphosphatase NTPase/RNA helicase and a 5'-RNA triphosphatase RTPase activities | Dengue virus | ? | - |
? | |
additional information | multifunctional enzyme showing nucleoside triphosphatase NTPase/RNA helicase and a 5'-RNA triphosphatase RTPase activities | Hepacivirus C | ? | - |
? | |
additional information | multifunctional enzyme showing nucleoside triphosphatase NTPase/RNA helicase and a 5'-RNA triphosphatase RTPase activities | West Nile virus | ? | - |
? | |
additional information | multifunctional enzyme showing nucleoside triphosphatase NTPase/RNA helicase and a 5'-RNA triphosphatase RTPase activities | Japanese encephalitis virus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NS3 | - |
Hepacivirus C |
NTPase/helicase | - |
Dengue virus |
NTPase/helicase | - |
Hepacivirus C |
NTPase/helicase | - |
West Nile virus |
NTPase/helicase | - |
Japanese encephalitis virus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Dengue virus |
7.5 | - |
assay at | Hepacivirus C |
7.5 | - |
assay at | West Nile virus |
7.5 | - |
assay at | Japanese encephalitis virus |