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3.6.1.15: nucleoside-triphosphate phosphatase

This is an abbreviated version!
For detailed information about nucleoside-triphosphate phosphatase, go to the full flat file.

Word Map on EC 3.6.1.15

Reaction

a nucleoside triphosphate
+
H2O
=
a nucleoside diphosphate
 +
phosphate

Synonyms

AAA-type nucleoside triphosphatase phosphohydrolase, ankyrin repeat-rich membrane spanning protein, cell division control protein Cdc48, DEAH-box Prp22 protein, DEAH-box splicing factor Prp22, DExH-Box NTPase, DR_0079, germ-cell-specific leucine-rich repeat protein, GP086L protein, HCR-NTPase, HrpB, HrpB NTPase, human cancer-related nucleoside triphosphatase, KAP NTPase, Kidins220, kinase D interacting substance of 220 kDa, LDBPK_100150, LdNTPDase2, LINF_150005200, LiNTPDase1, LMXM_10_0170, LMXM_15_0030, LmxNTPDase1, LmxNTPDase2, M86L protein, MC100R, Mg2+-dependent NTPase, More, Msm0858, NALP14, non-specific nucleoside triphosphatase, nonstructural protein 13, NPH I, NS3, NS3 protein, NS3FL, nsp13, NTP1, NTP3, NTPase, NTPase 1, NTPase 2, NTPase-I, NTPase-II, NTPase/helicase, NTPDase, NTPDase 1, NTPDase1, NTPDase2, nucleic acid-independent nucleoside triphosphatase, nucleoside 5-triphosphatase, nucleoside triphosphatase, nucleoside triphosphatase (NTPase)/helicase, nucleoside triphosphate diphospho-hydrolase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate diphosphohydrolase 1, nucleoside triphosphate hydrolase, nucleoside triphosphate hydrolases I, nucleoside triphosphate hydrolases II, nucleoside triphosphate phosphohydrolase, nucleoside triphosphate phosphohydrolase I, nucleoside-5-triphosphate phosphohydrolase, nucleoside-triphosphatase 1, nucleoside-triphosphatase 2, nucleotide 5'-triphosphatase, P-loop NTPase, phosphatase, nucleoside tri-, PilB, PilT, PilU, polypeptide p41, protein NS3, PVA coat protein, PVA CP, PVx coat protein, PVX CP, Rad55B, RNA-dependent nucleoside triphosphatase, SHVp41, Sso0909, T4P motor protein, type IV pilus motor protein, YtkD

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.15 nucleoside-triphosphate phosphatase

Turnover Number

Turnover Number on EC 3.6.1.15 - nucleoside-triphosphate phosphatase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0051 - 0.29
ADP
0.0086 - 4384
ATP
1.67
CDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.0073 - 2286
CTP
0.52
dADP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.057 - 3150
dATP
1.12
dCDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.3 - 5096
dCTP
0.51
dGDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.4 - 2500
dGTP
0.22
dITP
substrate concentration between 0.01 and 4.0 mM, 37°C
10.9
dTTP
-
pH 7.5, 23°C
82 - 1875
dUTP
0.39
GDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.0076 - 2963
GTP
0.06
IDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.18
ITP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.005
RNA
-
wild-type transcriptase cofactor my2, 22°C, 6.5-7.0
1.03
TDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.0074 - 0.69
TTP
1.35
UDP
substrate concentration between 0.01 and 4.0 mM, 37°C
0.007 - 2162
UTP
additional information
additional information
-
at optimum Mg2+ and saturating ATP concentrations 1 pmol of enzyme unwinds 5.5 fmol of DNA duplex per s
-