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3.4.17.20: Carboxypeptidase U

This is an abbreviated version!
For detailed information about Carboxypeptidase U, go to the full flat file.

Word Map on EC 3.4.17.20

Reaction

release of C-terminal Arg and Lys from a polypeptide =

Synonyms

aCAP, activated thrombin activable fibrinolysis inhibitor, activated thrombin-activable fibrinolysis inhibitor, activated thrombin-activatable fibrinolysis inhibitor, active carboxypeptidase B, active thrombin-activatable fibrinolysis inhibitor, Arginine carboxypeptidase, Carboxypeptidase B, pro-, carboxypeptidase B2, Carboxypeptidase R, carboxypeptidase U, Carboxypeptidase-U, CPB2, CPR, CPU, Plasma carboxypeptidase B, plasma carboxypeptidase U, plasma CPB, plasma procarboxypeptidase B, plasma procarboxypeptidase B-like proenzyme, plasma procarboxypeptidase U, pro-pCPB, Procarboxypeptidase B, procarboxypeptidase R, procarboxypeptidase U, proCPU, pTAFI, rTAFI, TAFI, TAFIa, TFAI, thrombin activable fibrinolysis inhibitor, thrombin activatable fibrinolysis inhibitor, Thrombin-activable fibrinolysis inhibitor, thrombin-activatable fibrinolysis inhibitor

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.17 Metallocarboxypeptidases
                3.4.17.20 Carboxypeptidase U

Cloned

Cloned on EC 3.4.17.20 - Carboxypeptidase U

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in BHK cells
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expression in BHK-cells
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expression in CHO cells
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expression of pro-CPU in Spodoptera frugiperda Sf21 and Trichoplusia ni H5 insect cells, the recombinant enzymes show different glycosylation patterns, expression rates, overview
expression of wild-type TAFI isozymes Thr147 and Thr325 and of two TAFI-carboxypeptidase B chimeric proteins, the CPB fragments fused to TAFI comprise residues 288-395 and 288-327, respectively, in baby hamster kidney cells
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gene CPB2, gene mapping, genetic organization, DNA and amino acid sequence determination and analysis, regulation of enzyme expression involves the glucocorticoid receptor and the CCAAT/enhancer binding protein sites, polymorphisms at positions 325, 147, and 505
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procarboxypeptidase R, expression in COS-7 cells
recombinant TAFI and TAFI/CPB(carboxypeptidase B) chimeras
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recombinant TAFI is expressed in BHK cells
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TAFI gene genotyping, polymorphisms lead to 25% of TAFI level variety, especially due to polymorphisms at 5'-G1102T and 3'-T1583A, isozyme variations at residue 325 being Thr or Ile, overview
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