3.4.16.2: lysosomal Pro-Xaa carboxypeptidase

This is an abbreviated version!
For detailed information about lysosomal Pro-Xaa carboxypeptidase, go to the full flat file.

Reaction

Cleavage of a -Pro-/-Xaa bond to release a C-terminal amino acid =

Synonyms

aminoacylproline carboxypeptidase, angiotensinase C, carboxypeptidase, carboxypeptidase A6, Carboxypeptidase P, Carboxypeptidase R, carboxypeptidase, aminoacylproline, carboxypeptidase, peptidylprolylamino acid, CPA6, CPP, EC 3.4.12.4, endothelial cell prekallikrein activator, HUVEC PK activator, lysosomal carboxypeptidase, lysosomal carboxypeptidase C, lysosomal Pro-X carboxypeptidase, matrix PK activator, PCP, PKA, plasma carboxypeptidase, plasma procarboxypeptidase B, PRCP, procarboxypeptidase U, proline carboxypeptidase, proline-specific carboxypeptidase P, prolyl carboxypeptidase, prolyl-carboxypeptidase, prolylcarboxypeptidase, serine protease prolylcarboxypeptidase, TAFI, thrombin-activatable fibrinolysis inhibitor

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.16 Serine-type carboxypeptidases

                3.4.16.2 lysosomal Pro-Xaa carboxypeptidase

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Results	in table
3	Activating Compound
114	AA Sequence
8	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
521	Disease/ Diagnostics
3	Expression
8	General Information
30	IC50 Value
72	Inhibitors
1	kcat/KM [mM/s]
7	Ki Value [mM]
24	KM Value [mM]
8	Localization
6	Metals/Ions
23	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
46	Organism
1	PDB ID
15	pH Optimum
6	pH Range
1	pH Stability
1	pI Value
3	Posttranslational Modification
3	Protein Variants
11	Purification (Commentary)
1	Reaction
9	Reaction Type
46	Reference
58	Source Tissue
5	Specific Activity [micromol/min/mg]
61	Substrates and Products (Substrate)
9	Subunits
65	Synonyms
10	Temperature Optimum [°C]
6	Temperature Stability [°C]
4	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.4.16.2 - lysosomal Pro-Xaa carboxypeptidase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

As2O3

Oryza sativa

-

when seedlings are raised under 25 and 50 microM As2O3 in the medium, the activity level of carboxypeptidase is enhanced

681612

thrombin

Mus musculus

-

-

683829

-

additional information

Homo sapiens

-

in cells, treated with 30 nM dexamethasone plus 1 nM DAMGO ([D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin), the prolyl-carboxypeptidase gene is up-regulated

683348

-