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3.4.16.2: lysosomal Pro-Xaa carboxypeptidase

This is an abbreviated version!
For detailed information about lysosomal Pro-Xaa carboxypeptidase, go to the full flat file.

Word Map on EC 3.4.16.2

Reaction

Cleavage of a -Pro-/-Xaa bond to release a C-terminal amino acid =

Synonyms

aminoacylproline carboxypeptidase, angiotensinase C, carboxypeptidase, carboxypeptidase A6, Carboxypeptidase P, Carboxypeptidase R, carboxypeptidase, aminoacylproline, carboxypeptidase, peptidylprolylamino acid, CPA6, CPP, EC 3.4.12.4, endothelial cell prekallikrein activator, HUVEC PK activator, lysosomal carboxypeptidase, lysosomal carboxypeptidase C, lysosomal Pro-X carboxypeptidase, matrix PK activator, PCP, PKA, plasma carboxypeptidase, plasma procarboxypeptidase B, PRCP, procarboxypeptidase U, proline carboxypeptidase, proline-specific carboxypeptidase P, prolyl carboxypeptidase, prolyl-carboxypeptidase, prolylcarboxypeptidase, serine protease prolylcarboxypeptidase, TAFI, thrombin-activatable fibrinolysis inhibitor

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.16 Serine-type carboxypeptidases
                3.4.16.2 lysosomal Pro-Xaa carboxypeptidase

Reference

Reference on EC 3.4.16.2 - lysosomal Pro-Xaa carboxypeptidase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tan, F.; Morris, P.W.; Skidgel, R.A.; Erdös, E.G.
Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families [published erratum appears in J Biol Chem 1993 Dec 5;268(34):26032
J. Biol. Chem.
268
16631-16638
1993
Homo sapiens
Manually annotated by BRENDA team
Odya, C.E.; Erdös, E.G.
Human prolylcarboxypeptidase
Methods Enzymol.
80
460-466
1981
Homo sapiens
Manually annotated by BRENDA team
Skidgel, R.A.; Wickstrom, E.; Kumamoto, K.; Erdös, E.G.
Rapid radioassay for prolylcarboxypeptidase (angiotensinase C)
Anal. Biochem.
118
113-119
1981
Homo sapiens
Manually annotated by BRENDA team
Odya, C.E.; Marinkovic, D.V.; Hammon, K.J.; Stewart, T.A.; Erdös, E.G.
Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney
J. Biol. Chem.
253
5927-5931
1978
Homo sapiens
Manually annotated by BRENDA team
Kakimoto, T.; Oshima, G.; Yeh, H.S.J.; Erdös, E.G.
Purification of lysosomal prolycarboxypeptidase angiotensinase C
Biochim. Biophys. Acta
302
178-182
1973
Sus scrofa
Manually annotated by BRENDA team
Yang, H.Y.T.; Erdös, E.G.; Chiang, T.S.
New enzymatic route for the inactivation of angiotensin
Nature
218
1224-1226
1968
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Jackman, H.L.; Tan, F.; Schraufnagel, D.; Dragovic, T.; Dezsö, B.; Becker, R.P.; Erdös, E.G.
Plasma membrane-bound and lysosomal peptidases in human alveolar macrophages
Am. J. Respir. Cell Mol. Biol.
13
196-204
1995
Homo sapiens
Manually annotated by BRENDA team
Suga, K.; Ito, K.; Tsuru, D.; Yoshimoto, T.
Prolylcarboxypeptidase (angiotensinase C): purification and characterization of the enzyme from Xanthomanas maltophilia
Biosci. Biotechnol. Biochem.
59
298-301
1995
Stenotrophomonas maltophilia
Manually annotated by BRENDA team
Gacko, M.; Worowska, A.; Glowinski, S.
Activity of lysosomal carboxypeptidase in aneurysmal aortic wall
Bull. Pol. Acad. Sci. Biol. Sci.
46
107-112
1998
Homo sapiens
-
Manually annotated by BRENDA team
Shariat-Madar, Z.; Mahdi, F.; Schmaier, A.H.
Recombinant prolylcarboxypeptidase activates plasma prekallikrein
Blood
15
4554-4561
2004
Homo sapiens
Manually annotated by BRENDA team
Moreira, C.R.; Schmaier, A.H.; Mahdi, F.; da Motta, G.; Nader, H.B.; Shariat-Madar, Z.
Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator
FEBS Lett.
523
167-170
2002
Homo sapiens
Manually annotated by BRENDA team
Shariat-Madar, Z.; Mahdi, F.; Schmaier, A.H.
Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator
J. Biol. Chem.
277
17962-17969
2002
Homo sapiens
Manually annotated by BRENDA team
Shariat-Madar, Z.; Rahimy, E.; Mahdi, F.; Schmaier, A.H.
Overexpression of prolylcarboxypeptidase enhances plasma prekallikrein activation on Chinese hamster ovary cells
Am. J. Physiol.
289
H2697-H2703
2005
Homo sapiens
Manually annotated by BRENDA team
Shariat-Madar, Z.; Mahdi, F.; Schmaier, A.H.
Recombinant prolylcarboxypeptidase activates plasma prekallikrein
Blood
103
4554-4561
2004
Homo sapiens
Manually annotated by BRENDA team
Tan, F.; Erdoes, E.G.
Lysosomal Pro-X carboxypeptidase
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
2
1936-1938
2004
Sus scrofa
-
Manually annotated by BRENDA team
Mishra, S.; Dubey, R.S.
Inhibition of ribonuclease and protease activities in arsenic exposed rice seedlings: role of proline as enzyme protectant
J. Plant Physiol.
163
927-936
2006
Oryza sativa
Manually annotated by BRENDA team
Wang, L.; Feng, Y.; Zhang, Y.; Zhou, H.; Jiang, S.; Niu, T.; Wei, L.J.; Xu, X.; Xu, X.; Wang, X.
Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia
Am. J. Obstet. Gynecol.
195
162-171
2006
Homo sapiens
Manually annotated by BRENDA team
Furusawa, H.; Takano, H.; Okahata, Y.
Transient kinetic studies of pH-dependent hydrolyses by exo-type carboxypeptidase P on a 27-MHz quartz crystal microbalance
Anal. Chem.
80
1005-1011
2008
Penicillium janthinellum
Manually annotated by BRENDA team
Perkins, R.; Ngo, M.D.; Mahdi, F.; Shariat-Madar, Z.
Identification of lipopolysaccharide binding site on high molecular weight kininogen
Biochem. Biophys. Res. Commun.
366
938-943
2008
Homo sapiens
Manually annotated by BRENDA team
Ward, G.R.; Franklin, S.O.; Gerald, T.M.; Dempsey, K.T.; Clodfelter, D.E.; Krissinger, D.J.; Patel, K.M.; Vrana, K.E.; Howlett, A.C.
Glucocorticoids plus opioids up-regulate genes that influence neuronal function
Cell. Mol. Neurobiol.
27
651-660
2007
Homo sapiens
Manually annotated by BRENDA team
Mallela, J.; Yang, J.; Shariat-Madar, Z.
Prolylcarboxypeptidase: A cardioprotective enzyme
Int. J. Biochem. Cell Biol.
41
477-481
2009
Homo sapiens
Manually annotated by BRENDA team
Lyons, P.J.; Callaway, M.B.; Fricker, L.D.
Characterization of carboxypeptidase a6, an extracellular matrix peptidase
J. Biol. Chem.
283
7054-7063
2008
Homo sapiens
Manually annotated by BRENDA team
Huang, X.D.; Tong, W.W.; Fan, X.L.; Li, Z.H.
Application of HPLC-ESI-ITMS in the quality control of carboxyterminal sequence confirmation for the recombinant DNA product Hirudin Variant 3
J. Pharm. Biomed. Anal.
43
533-539
2007
Penicillium janthinellum
Manually annotated by BRENDA team
Wang, X.; Smith, P.L.; Hsu, M.Y.; Tamasi, J.A.; Bird, E.; Schumacher, W.A.
Deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI) protected mice from ferric chloride-induced vena cava thrombosis
J. Thromb. Thrombolysis
23
41-49
2007
Mus musculus
Manually annotated by BRENDA team
Furusawa, H.; Takano, H.; Okahata, Y.
Transient kinetic studies of protein hydrolyses by endo- and exo-proteases on a 27 MHz quartz-crystal microbalance
Org. Biomol. Chem.
6
727-731
2008
Penicillium janthinellum
Manually annotated by BRENDA team
Mallela, J.; Perkins, R.; Yang, J.; Pedigo, S.; Rimoldi, J.M.; Shariat-Madar, Z.
The functional importance of the N-terminal region of human prolylcarboxypeptidase
Biochem. Biophys. Res. Commun.
374
635-640
2008
Homo sapiens
Manually annotated by BRENDA team
Iwatsuki, M.; Koizumi, Y.; Gouda, H.; Hirono, S.; Tomoda, H.; Omura, S.
Lys17 in the lasso peptide lariatin A is responsible for anti-mycobacterial activity
Bioorg. Med. Chem. Lett.
19
2888-2890
2009
Penicillium janthinellum
Manually annotated by BRENDA team
Abeywickrema, P.D.; Patel, S.B.; Byrne, N.J.; Diehl, R.E.; Hall, D.L.; Ford, R.E.; Rickert, K.W.; Reid, J.C.; Shipman, J.M.; Geissler, W.M.; Pryor, K.D.; SinhaRoy, R.; Soisson, S.M.; Lumb, K.J.; Sharma, S.
Expression, purification and crystallization of human prolylcarboxypeptidase
Acta Crystallogr. Sect. F
66
702-705
2010
Homo sapiens (P42785)
Manually annotated by BRENDA team
Zhang, Y.; Hong, X.M.; Xing, H.X.; Li, J.P.; Huo, Y.; Xu, X.P.
E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients
Chin. Med. Sci.
122
2461-2465
2009
Homo sapiens
Manually annotated by BRENDA team
Qin, X.; Zeng, S.; Tian, H.; Deng, S.; Ren, J.; Zheng, Y.; Li, D.; Li, Y.; Liao, D.; Chen, S.
Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats
Clin. Exp. Pharmacol. Physiol.
36
319-324
2009
Rattus norvegicus (D4AA31)
Manually annotated by BRENDA team
Palmiter, R.D.
Reduced levels of neurotransmitter-degrading enzyme PRCP promote obesity
J. Clin. Invest.
119
2130-2133
2009
Mus musculus (Q7TMR0)
Manually annotated by BRENDA team
Wallingford, N.; Perroud, B.; Gao, Q.; Coppola, A.; Gyengesi, E.; Liu, Z.W.; Gao, X.B.; Diament, A.; Haus, K.A.; Shariat-Madar, Z.; Mahdi, F.; Wardlaw, S.L.; Schmaier, A.H.; Warden, C.H.; Diano, S.
Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents
J. Clin. Invest.
119
2291-2303
2009
Mus musculus
Manually annotated by BRENDA team
Ngo, M.L.; Mahdi, F.; Kolte, D.; Shariat-Madar, Z.
Upregulation of prolylcarboxypeptidase (PRCP) in lipopolysaccharide (LPS) treated endothelium promotes inflammation
J. Inflamm.
6
1-9
2009
Homo sapiens
Manually annotated by BRENDA team
Zhao, X.; Southwick, K.; Cardasis, H.L.; Du, Y.; Lassman, M.E.; Xie, D.; El-Sherbeini, M.; Geissler, W.M.; Pryor, K.D.; Verras, A.; Garcia-Calvo, M.; Shen, D.M.; Yates, N.A.; Pinto, S.; Hendrickon, R.C.
Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase
Proteomics
10
2882-2886
2010
Homo sapiens
Manually annotated by BRENDA team
Graham, T.H.; Liu, W.; Verras, A.; Sebhat, I.K.; Xiong, Y.; Bleasby, K.; Bhatt, U.R.; Chen, Q.; Garcia-Calvo, M.; Geissler, W.M.; Gorski, J.N.; He, H.; Lassman, M.E.; Lisnock, J.; Li, X.; Shen, Z.; Tong, X.; Tung, E.C.; Wiltsie, J.; Xiao, J.; Xie, D.; Xu, S.; Hale, J.J.; Pinto, S.; Shen, D.M.
A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation
Bioorg. Med. Chem. Lett.
22
2811-2817
2012
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Graham, T.H.; Liu, W.; Verras, A.; Reibarkh, M.; Bleasby, K.; Bhatt, U.R.; Chen, Q.; Garcia-Calvo, M.; Geissler, W.M.; Gorski, J.N.; He, H.; Lassman, M.E.; Lisnock, J.; Li, X.; Shen, Z.; Tong, X.; Tung, E.C.; Wiltsie, J.; Xie, D.; Xu, S.; Xiao, J.; Hale, J.J.; Pinto, S.; Shen, D.M.
A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes
Bioorg. Med. Chem. Lett.
22
2818-2822
2012
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Graham, T.H.; Shu, M.; Verras, A.; Chen, Q.; Garcia-Calvo, M.; Li, X.; Lisnock, J.; Tong, X.; Tung, E.C.; Wiltsie, J.; Hale, J.J.; Pinto, S.; Shen, D.M.
Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors
Bioorg. Med. Chem. Lett.
24
1657-1660
2014
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Jeong, J.K.; Diano, S.
Prolyl carboxypeptidase mRNA expression in the mouse brain
Brain Res.
1542
85-92
2014
Mus musculus
Manually annotated by BRENDA team
Goptar, I.A.; Shagin, D.A.; Shagina, I.A.; Mudrik, E.S.; Smirnova, Y.A.; Zhuzhikov, D.P.; Belozersky, M.A.; Dunaevsky, Y.E.; Oppert, B.; Filippova, I.Y.; Elpidina, E.N.
A digestive prolyl carboxypeptidase in Tenebrio molitor larvae
Insect Biochem. Mol. Biol.
43
501-509
2013
Tenebrio molitor (C5H0E3), Tenebrio molitor
Manually annotated by BRENDA team
Duan, L.; Ying, G.; Danzer, B.; Perez, R.E.; Shariat-Madar, Z.; Levenson, V.V.; Maki, C.G.
The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT
J. Biol. Chem.
289
21694-21705
2014
Homo sapiens
Manually annotated by BRENDA team
Kehoe, K.; Brouns, R.; Verkerk, R.; Engelborghs, S.; De Deyn, P.; Hendriks, D.; De Meester, I.
Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke
Neurochem. Res.
40
81-88
2014
Homo sapiens
Manually annotated by BRENDA team
Grobe, N.; Weir, N.M.; Leiva, O.; Ong, F.S.; Bernstein, K.E.; Schmaier, A.H.; Morris, M.; Elased, K.M.
Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry
Am. J. Physiol. Cell Physiol.
304
C945-C953
2013
Mus musculus
Manually annotated by BRENDA team