3.4.16.2: lysosomal Pro-Xaa carboxypeptidase

This is an abbreviated version!
For detailed information about lysosomal Pro-Xaa carboxypeptidase, go to the full flat file.

Reaction

Cleavage of a -Pro-/-Xaa bond to release a C-terminal amino acid =

Synonyms

aminoacylproline carboxypeptidase, angiotensinase C, carboxypeptidase, carboxypeptidase A6, Carboxypeptidase P, Carboxypeptidase R, carboxypeptidase, aminoacylproline, carboxypeptidase, peptidylprolylamino acid, CPA6, CPP, EC 3.4.12.4, endothelial cell prekallikrein activator, HUVEC PK activator, lysosomal carboxypeptidase, lysosomal carboxypeptidase C, lysosomal Pro-X carboxypeptidase, matrix PK activator, PCP, PKA, plasma carboxypeptidase, plasma procarboxypeptidase B, PRCP, procarboxypeptidase U, proline carboxypeptidase, proline-specific carboxypeptidase P, prolyl carboxypeptidase, prolyl-carboxypeptidase, prolylcarboxypeptidase, serine protease prolylcarboxypeptidase, TAFI, thrombin-activatable fibrinolysis inhibitor

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.16 Serine-type carboxypeptidases

                3.4.16.2 lysosomal Pro-Xaa carboxypeptidase

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Results	in table
3	Activating Compound
114	AA Sequence
8	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
521	Disease/ Diagnostics
3	Expression
8	General Information
30	IC50 Value
72	Inhibitors
1	kcat/KM [mM/s]
7	Ki Value [mM]
24	KM Value [mM]
8	Localization
6	Metals/Ions
23	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
46	Organism
1	PDB ID
15	pH Optimum
6	pH Range
1	pH Stability
1	pI Value
3	Posttranslational Modification
3	Protein Variants
11	Purification (Commentary)
1	Reaction
9	Reaction Type
46	Reference
58	Source Tissue
5	Specific Activity [micromol/min/mg]
61	Substrates and Products (Substrate)
9	Subunits
65	Synonyms
10	Temperature Optimum [°C]
6	Temperature Stability [°C]
4	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.16.2 - lysosomal Pro-Xaa carboxypeptidase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

2 entries

a cDNA fragment encoding human pro-CPA6 is subcloned into the pcDNA3.1 vector

Homo sapiens

-

683683

cDNA cloned in pMT/BIP/V5-HIS-C, transfected into Schneider insect cells

Homo sapiens

-

650716

cloned in pMT/BIP/V5-HIS-C, transfected into Scheider insect cells

Homo sapiens

-

664442

expressed in AT-20 cells

Homo sapiens

-

683683

expressed in Schneider insect cells

Homo sapiens

-

696003

overexpression in Chineses hamster ovary cells. CHO cells are transfected with full-length prolylcarboxypeptidase under the control of a cytomegalovirus promoter. CHO recombinant prolylcarboxypeptidase is expressed as a fusion protein with COOH-terminal enhanced green fluorescence protein. Overexpression in the external membrane

Homo sapiens

-

663587

PrCP is cloned with an N-terminal FLAG tag and a C-terminal heptahistidine tag under the trypsin II signal sequence in pcDNA5/FRT and expressed in stably transfected CHO cells

Homo sapiens

P42785

706993

-

Homo sapiens

-

36267

-

Tenebrio molitor

C5H0E3

731918