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3.4.16.2: lysosomal Pro-Xaa carboxypeptidase

This is an abbreviated version!
For detailed information about lysosomal Pro-Xaa carboxypeptidase, go to the full flat file.

Word Map on EC 3.4.16.2

Reaction

Cleavage of a -Pro-/-Xaa bond to release a C-terminal amino acid =

Synonyms

aminoacylproline carboxypeptidase, angiotensinase C, carboxypeptidase, carboxypeptidase A6, Carboxypeptidase P, Carboxypeptidase R, carboxypeptidase, aminoacylproline, carboxypeptidase, peptidylprolylamino acid, CPA6, CPP, EC 3.4.12.4, endothelial cell prekallikrein activator, HUVEC PK activator, lysosomal carboxypeptidase, lysosomal carboxypeptidase C, lysosomal Pro-X carboxypeptidase, matrix PK activator, PCP, PKA, plasma carboxypeptidase, plasma procarboxypeptidase B, PRCP, procarboxypeptidase U, proline carboxypeptidase, proline-specific carboxypeptidase P, prolyl carboxypeptidase, prolyl-carboxypeptidase, prolylcarboxypeptidase, serine protease prolylcarboxypeptidase, TAFI, thrombin-activatable fibrinolysis inhibitor

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.16 Serine-type carboxypeptidases
                3.4.16.2 lysosomal Pro-Xaa carboxypeptidase

Substrates Products

Substrates Products on EC 3.4.16.2 - lysosomal Pro-Xaa carboxypeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(des-Arg9)-bradykinin + H2O
?
show the reaction diagram
-
enzyme cleaves the -Pro7-/-Phe8-OH bond
-
-
?
1-dimethylaminonaphthalene-5-sulfonyl-Pro-Phe + H2O
1-dimethylaminonaphthalene-5-sulfonyl-Pro + Phe
show the reaction diagram
-
-
-
-
?
3-(2-furyl)acryloyl-peptide + H2O
?
show the reaction diagram
-
substrate used in the carboxypeptidase assay
-
-
?
4-phenylazobenzyloxycarbonyl-Pro-Leu + H2O
4-phenylazobenzyloxycarbonyl-Pro + Leu
show the reaction diagram
-
-
-
-
?
7-methoxycoumarin-4-acetyl-Pro-Pro-Lys + H2O
?
show the reaction diagram
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
alpha-melanocyte-stimulating hormone + H2O
?
show the reaction diagram
angiotensin II + H2O
?
show the reaction diagram
angiotensin III + H2O
?
show the reaction diagram
-
-
-
-
?
angiotensin III + H2O
angiotensin 2-7 + phenylalanine
show the reaction diagram
-
mutant DELTA317-496 is able to carry out this reaction
-
-
?
dansyl-Pro-Phe + H2O
dansyl-Pro + Phe
show the reaction diagram
-
-
-
-
?
Gliadin + H2O
?
show the reaction diagram
-
enzyme is able to cleave gliadins, the major dietary proteins of Tenebrio molitor larvae
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
L-Ala-L-Pro 4-nitroanilide + H2O
L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
lariatin A + H2O
?
show the reaction diagram
-
C-terminal-lacking fragments of the anti-mycobacterial peptide lariatin A, isolated from a culture broth of Rhodococcus jostii, are obtained by hydrolysis using carboxypeptidase P and their anti-mycobacterial activities are evaluated. Lys17 is found to be essential for their antimicrobial activity
-
-
?
Myoglobin + H2O
?
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-Gly-L-Pro 4-nitroanilide + H2O
N-benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
N-benzyloxycarbonyl-Gly-Pro-Phe + H2O
N-benzyloxycarbonyl-Gly-Pro + Phe
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-L-Ala-L-Ala-L-Pro 4-nitroanilide + H2O
N-benzyloxycarbonyl-L-Ala-L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
N-benzyloxycarbonyl-L-Ala-L-Pro 4-nitroanilide + H2O
N-benzyloxycarbonyl-L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
N-benzyloxycarbonyl-L-Pro 4-nitroanilide + H2O
N-benzyloxycarbonyl-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
N-benzyloxycarbonyl-L-Pro-L-Ala + H2O
N-benzyloxycarbonyl-L-Pro + L-Ala
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-L-Pro-L-Phe + H2O
N-benzyloxycarbonyl-L-Pro + L-Phe
show the reaction diagram
-
-
-
?
N-benzyloxycarbonyl-L-Pro-Leu + H2O
N-benzyloxycarbonyl-L-Pro + L-Leu
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-Pro-Ala + H2O
N-benzyloxycarbonyl-Pro + Ala
show the reaction diagram
N-benzyloxycarbonyl-Pro-Leu + H2O
N-benzyloxycarbonyl-Pro + Leu
show the reaction diagram
N-benzyloxycarbonyl-Pro-Phe + H2O
N-benzyloxycarbonyl-Pro + Phe
show the reaction diagram
N-benzyloxycarbonyl-Pro-Ser + H2O
N-benzyloxycarbonyl-Pro + Ser
show the reaction diagram
-
7% of the activity with angiotensin III
-
-
?
N-benzyloxycarbonyl-Pro-Val + H2O
N-benzyloxycarbonyl-Pro + Val
show the reaction diagram
prekallikrein + H2O
?
show the reaction diagram
-
-
-
?
saralasin + H2O
?
show the reaction diagram
-
-
-
-
?
YPRPIHPA + H2O
?
show the reaction diagram
-
using a peptidomic approach a single peptide YPRPIHPA is identified as a novel substrate for PRCP in human cerebrospinal fluid. The peptide YPRPIHPA is from the extracellular portion of human endothelin B receptor like protein 2
-
-
?
[des-Arg9]bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-