3.4.16.2: lysosomal Pro-Xaa carboxypeptidase

This is an abbreviated version!
For detailed information about lysosomal Pro-Xaa carboxypeptidase, go to the full flat file.

Word Map on EC 3.4.16.2

3.4.16.2

aminopeptidase

potato

pancreatic

fibrinolysis

cathepsins

bradykinin

b-like

angiotensin-converting

mast

thrombin

clot

exopeptidase

neuropeptides

edman

chymotrypsin

plasminogen

dipeptidyl

ace2

tafia

enkephalin

kinin

thrombin-activatable

zymogen

endopeptidases

fibrin

convertase

kininase

activatable

plasmin

prohormone

chymase

anaphylatoxins

trypsin-like

thrombomodulin

tryptase

endoproteolytic

detyrosinated

captopril

i-converting

galactosialidosis

antifibrinolytic

leech

polyglutamylation

3.4.15.1

bestatin

phosphoramidon

c3a

enkephalinase

kallidin

transpeptidation

analysis

medicine

Reaction

Cleavage of a -Pro-/-Xaa bond to release a C-terminal amino acid =

Synonyms

aminoacylproline carboxypeptidase, angiotensinase C, carboxypeptidase, carboxypeptidase A6, Carboxypeptidase P, Carboxypeptidase R, carboxypeptidase, aminoacylproline, carboxypeptidase, peptidylprolylamino acid, CPA6, CPP, EC 3.4.12.4, endothelial cell prekallikrein activator, HUVEC PK activator, lysosomal carboxypeptidase, lysosomal carboxypeptidase C, lysosomal Pro-X carboxypeptidase, matrix PK activator, PCP, PKA, plasma carboxypeptidase, plasma procarboxypeptidase B, PRCP, procarboxypeptidase U, proline carboxypeptidase, proline-specific carboxypeptidase P, prolyl carboxypeptidase, prolyl-carboxypeptidase, prolylcarboxypeptidase, serine protease prolylcarboxypeptidase, TAFI, thrombin-activatable fibrinolysis inhibitor

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.16 Serine-type carboxypeptidases

3.4.16.2 lysosomal Pro-Xaa carboxypeptidase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
3	Activating Compound
114	AA Sequence
8	Application
1	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
521	Disease/ Diagnostics
3	Expression
8	General Information
30	IC50 Value
72	Inhibitors
1	kcat/KM [mM/s]
7	Ki Value [mM]
24	KM Value [mM]
8	Localization
6	Metals/Ions
23	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
46	Organism
1	PDB ID
15	pH Optimum
6	pH Range
1	pH Stability
1	pI Value
3	Posttranslational Modification
3	Protein Variants
11	Purification (Commentary)
1	Reaction
9	Reaction Type
46	Reference
58	Source Tissue
5	Specific Activity [micromol/min/mg]
61	Substrates and Products (Substrate)
9	Subunits
65	Synonyms
10	Temperature Optimum [°C]
6	Temperature Stability [°C]
4	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

IC50 Value on EC 3.4.16.2 - lysosomal Pro-Xaa carboxypeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to IC50 Value Search

0.000066 - 0.00018

(3R,4R)-4-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]-1-(2,2-dimethylpropyl)-3-(4-fluorophenyl)piperidine

2 entries

0.0000007 - 0.0000033

2-[4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-1-(2-phenylethyl)piperidin-4-yl]pyridine

2 entries

angiotensin I

Homo sapiens

696003

0.002 - 3

angiotensin II

3 entries

0.002 - 0.05

antipain

2 entries

0.001

benzyloxycarbonyl-Pro-Pro-aldehyde dimethyl acetal

Homo sapiens

IC50: 0.001 mM

652251

0.5

benzyloxycarbonyl-Pro-prolinal

Homo sapiens

IC50: 0.5 mM, inhibits hydrolysis of H-Gly-Pro-4-nitroanilide

650716

0.007

Benzylsuccinic acid

Homo sapiens

683683

0.1 - 3

bradykinin

2 entries

0.00004 - 0.0001

corn trypsin inhibitor

2 entries

0.00005

diisopropyl fluorophosphonate

Homo sapiens

IC50: 50 nM

650716

0.5

HgCl2

Homo sapiens

IC50: 0.5 mM

652251

0.8

leupeptin

Homo sapiens

IC50: 0.8 mM, inhibits hydrolysis of Gly-Pro-4-nitroanilide

650716

0.00005

N-(9-fluorenyl)methoxycarbonyl-Ala-Pyr-CN

Homo sapiens

IC50: 50 nM

652251

0.1

N-(9-fluorenyl)methoxycarbonyl-aminoacylpyrrolidine-2-nitrile

Homo sapiens

IC50: 0.1 mM

651307

0.6

phenylmethylsulfonyl fluoride

Homo sapiens

IC50: 0.6 mM

650716

0.00005

potato carboxypeptidase inhibitor

Homo sapiens

683683

0.0000003 - 0.0000004

[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl](4-[(1Z)-1-[(2,5-dichlorophenyl)amino]-3-iminobut-1-en-1-yl]piperidin-1-yl)methanone

2 entries

0.0000002 - 0.0000003

[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl](4-[(1Z)-1-[(3-chloro-4-fluorophenyl)amino]-3-iminoprop-1-en-1-yl]piperidin-1-yl)methanone

2 entries

0.0000002 - 0.0000003

[4-[1-(3-chloro-4-fluorophenyl)-1H-pyrazol-5-yl]piperidin-1-yl][(1R,2R,4S)-2-(2,4-difluorophenyl)-4-(dimethylamino)-4-methylcyclopentyl]methanone

2 entries