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3.1.6.4: N-acetylgalactosamine-6-sulfatase

This is an abbreviated version!
For detailed information about N-acetylgalactosamine-6-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.4

Reaction

D-GalNAc-6-sulfate
+
H2O
=
D-GalNAc
+
sulfate

Synonyms

6-sulfatase, acetylgalactosamine 6-sulfatase, AtsA2, chondroitin sulfatase, chondroitinase, chondroitinsulfatase, galactose-6-sulfatase, galactose-6-sulfate sulfatase, GalNAc6S sulfatase, GALNS, N-acetylgalactosamine 6-sulfatase, N-acetylgalactosamine 6-sulphate sulphatase, N-acetylgalactosamine-6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, sulfatase, acetylgalactosamine 6-, sulfatase, chondroitin

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.4 N-acetylgalactosamine-6-sulfatase

Inhibitors

Inhibitors on EC 3.1.6.4 - N-acetylgalactosamine-6-sulfatase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,4-dideoxy-1,4-imino-D-arabinitol-gold
gold glyconanoparticles decorated with the natural iminosugar 1,4-dideoxy-1,4-imino-D-arabinitol, i.e. DAB-1 strongly and selectively inhibit N-acetylgalactosamine-6-sulfatase. The strategy employed allowed the enhancement of the multivalent presentation of the iminosugar onto the surface of gold nanoparticles
6-Sulfated heptasaccharides
-
strong
-
6-Sulfated pentasaccharides
-
strong
-
chondroitin 4-sulfate
-
slight
chondroitin 6-sulfate
-
competitive
Chondroitin 6-sulfate tetrasaccharide
-
slight
dermatan sulfate
-
slight
Fe3+
-
-
heparan sulfate
-
competitive
heparin
Hg2+
-
-
hyaluronic acid
-
slight
Keratan sulfate
-
competitive
Mg2+
-
-
Mn2+
-
-
Na2HPO4
-
-
Na2SO4
-
-
NaH2PO4
-
-
NO3-
-
-
S2O32-
-
-
SO32-
-
-
Zn2+
-
-