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3.1.6.4: N-acetylgalactosamine-6-sulfatase

This is an abbreviated version!
For detailed information about N-acetylgalactosamine-6-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.4

Reaction

D-GalNAc-6-sulfate
+
H2O
=
D-GalNAc
 +
sulfate

Synonyms

6-sulfatase, acetylgalactosamine 6-sulfatase, AtsA2, chondroitin sulfatase, chondroitinase, chondroitinsulfatase, galactose-6-sulfatase, galactose-6-sulfate sulfatase, GalNAc6S sulfatase, GALNS, N-acetylgalactosamine 6-sulfatase, N-acetylgalactosamine 6-sulphate sulphatase, N-acetylgalactosamine-6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, sulfatase, acetylgalactosamine 6-, sulfatase, chondroitin

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.4 N-acetylgalactosamine-6-sulfatase

Engineering

Engineering on EC 3.1.6.4 - N-acetylgalactosamine-6-sulfatase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A291D
mutation associated with attenuated phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, , in wild-type, A291 has a hydrogen bond with K310
A291T
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking. In wild-type, A291 has a hydrogen bond with K310. Mutation A291T produces a new hydrogen bond with G301
C79S
-
no enzymatic activity
C79T
-
no enzymatic activity
C79Y
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
F97V
-
10fold decrease in enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
G155R
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
G168R
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
G290S
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
G301C
G309R
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
G389del
-
mutation leads to mucopolysaccharidosis IVA
G929del
-
mutation leads to mucopolysaccharidosis IVA
H142R
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
H166Q
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
H236D
mutation associated with an attenuated phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, residue is involved in the ligand-enzyme interaction
I113F
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
K310N
mutation associated with attenuated phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, , residue is involved in enzyme-ligand interaction
L67M
-
N-acetylgalactosamine-6-sulfatase mutation of a mucopolysaccharidosis type IV tunisian patient
M318R
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
N204K
-
decreased enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
N289S
mutation associated with an attenuated phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, , residue is involved in the ligand-enzyme interaction
P125L
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
P151L
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
P179S
-
mutation leads to mucopolysaccharidosis IVA
P357L
-
mutation leads to mucopolysaccharidosis IVA
Q473X
-
mutation leads to mucopolysaccharidosis IVA
R295Q
-
decreased enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
R386C
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
R94C
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
R94G
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
S162F
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
S80L
mutation associated with a severe phenotype of lysosomal storage disease Mucopolysaccharidosis IV A, modeling of energy minimization and affinity energy after docking
T312S
-
decreased enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
T763del
-
mutation leads to mucopolysaccharidosis IVA
V138A
-
no enzymatic activity, no mature polypeptide chain and precursor polypeptide is faintly visible
C76S
active site mutation, results in inactive enzyme
additional information