3.1.6.4: N-acetylgalactosamine-6-sulfatase

This is an abbreviated version!
For detailed information about N-acetylgalactosamine-6-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.4

3.1.6.4

mucopolysaccharidosis

lysosomal

morquio

keratan

glycosaminoglycans

dysplasia

chondroitin-6-sulfate

sulfatases

arylsulfatase

elosulfase

n-acetylgalactosamine-4-sulfatase

medicine

kyphoscoliosis

odontoid

sumf1

synthesis

sanfilippo

pectus

platyspondyly

carinatum

valgum

Reaction

Synonyms

6-sulfatase, acetylgalactosamine 6-sulfatase, AtsA2, chondroitin sulfatase, chondroitinase, chondroitinsulfatase, galactose-6-sulfatase, galactose-6-sulfate sulfatase, GalNAc6S sulfatase, GALNS, N-acetylgalactosamine 6-sulfatase, N-acetylgalactosamine 6-sulphate sulphatase, N-acetylgalactosamine-6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, sulfatase, acetylgalactosamine 6-, sulfatase, chondroitin

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.6 Sulfuric-ester hydrolases

3.1.6.4 N-acetylgalactosamine-6-sulfatase

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Results	in table
6	Activating Compound
802	AA Sequence
12	Application
2	CAS Registry Number
9	Cloned(Commentary)
1	Crystallization (Commentary)
778	Disease/ Diagnostics
1	Expression
7	General Information
2	General Stability
1	IC50 Value
40	Inhibitors
14	KM Value [mM]
5	Localization
23	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
45	Organism
2	Pathway
4	PDB ID
12	pH Optimum
2	pH Range
3	Posttranslational Modification
42	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
43	Reference
38	Source Tissue
7	Specific Activity [micromol/min/mg]
4	Storage Stability
55	Substrates and Products (Substrate)
7	Subunits
31	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Stability [°C]

Molecular Weight

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Molecular Weight on EC 3.1.6.4 - N-acetylgalactosamine-6-sulfatase

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100000

gel filtration

120000

15000

19000

39000

40000

52000 - 53000

N204K mutant, precursor protein lacking one carbohydrate chain, SDS-PAGE

651453

55000

Homo sapiens

precursor protein, SDS-PAGE

651453

57000

Homo sapiens

x * 19000, x * 39000, x * 57000, the active enzyme contains either the 57000 Da polypeptide or disulfide-linked 39000 Da and 19000 Da polypeptides

135656

58000

Homo sapiens

recombinant precursor enzyme, gel filtration

60000

62000

gel filtration

78000

x * 78000, SDS-PAGE

85000

x * 85000, SDS-PAGE

90000

gel filtration

additional information

Homo sapiens

in normal cells N-acetylgalactosamine-6-sulfate sulfatase is in a 1.27 MDa complex with three other lysosomal hydrolases: beta-galactosidase, alpha-neuraminidase, and cathepsin A

135653