3.1.6.4: N-acetylgalactosamine-6-sulfatase
This is an abbreviated version!
For detailed information about N-acetylgalactosamine-6-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.4
-
3.1.6.4
-
mucopolysaccharidosis
-
lysosomal
-
morquio
-
keratan
-
glycosaminoglycans
-
dysplasia
-
chondroitin-6-sulfate
-
sulfatases
-
arylsulfatase
-
elosulfase
-
n-acetylgalactosamine-4-sulfatase
-
medicine
-
kyphoscoliosis
-
odontoid
-
sumf1
-
synthesis
-
sanfilippo
-
pectus
-
platyspondyly
-
carinatum
-
valgum
- 3.1.6.4
- mucopolysaccharidosis
- lysosomal
- morquio
- keratan
- glycosaminoglycans
- dysplasia
- chondroitin-6-sulfate
-
sulfatases
- arylsulfatase
-
elosulfase
- n-acetylgalactosamine-4-sulfatase
- medicine
-
kyphoscoliosis
-
odontoid
- sumf1
- synthesis
-
sanfilippo
-
pectus
-
platyspondyly
-
carinatum
-
valgum
Reaction
Synonyms
6-sulfatase, acetylgalactosamine 6-sulfatase, AtsA2, chondroitin sulfatase, chondroitinase, chondroitinsulfatase, galactose-6-sulfatase, galactose-6-sulfate sulfatase, GalNAc6S sulfatase, GALNS, N-acetylgalactosamine 6-sulfatase, N-acetylgalactosamine 6-sulphate sulphatase, N-acetylgalactosamine-6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase, sulfatase, acetylgalactosamine 6-, sulfatase, chondroitin
ECTree
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Reference on EC 3.1.6.4 - N-acetylgalactosamine-6-sulfatase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gloessl, J.; Truppe, W.; Kresse, H.
Purification and properties of N-acetylgalactosamine 6-sulphate sulphatase from human placenta
Biochem. J.
181
37-46
1979
Homo sapiens
Nakazawa, K.; Kagabe, K.
Galactose-6-sulfatase from Actinobacillus sp. IFO-13310 and its action on sulfated oligosaccharides from keratan sulfate
Biochim. Biophys. Acta
527
391-402
1978
Actinobacillus sp., Actinobacillus sp. IFO-13310
Lim, C.T.; Horwitz, A.L.
Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase
Biochim. Biophys. Acta
657
344-355
1981
Homo sapiens
Hayashi, S.
Study on the degradation of glycosaminoglycans by canine liver lysosomal enzymes. II. The contributions of hyaluronidase, beta-glucuronidase, sulfatase, and beta-N-acetylhexosaminidase in the case of chondroitin 4-sulfate
J. Biochem.
83
149-157
1978
Canis sp.
Singh, J.; di Ferrante, N.; Niebes, P.; Tavella, D.
N-Acetylgalactosamine-6-sulfate sulfatase in man. Absence of the enzyme in Morquio disease
J. Clin. Invest.
57
1036-1040
1976
Homo sapiens
Salyers, A.A.; O'Brien, M.
Cellular location of enzymes involved in chondroitin sulfate breakdown by Bacteroides thetaiotaomicron
J. Bacteriol.
143
772-780
1980
Bacteroides thetaiotaomicron
Nakanishi, Y.; Tsuji, M.; Habuchi, H.; Suzuki, S.
Isolation of UDP-N-acetylgalactosamine-6-sulfate sulfatase from quail oviduct and its action on chondroitin sulfate
Biochem. Biophys. Res. Commun.
89
863-870
1979
Coturnix coturnix, Coturnix coturnix Japonica
Habuchi, H.; Tsuji, M.; Nakanishi, Y.; Suzuki, S.
Separation and properties of five glycosaminoglycan sulfatases from rat skin
J. Biol. Chem.
254
7570-7578
1979
Rattus norvegicus
Pshezhetsky, A.V.; Potier, M.
Association of N-acetylgalactosamine-6-sulfate sulfatase with the multienzyme lysosomal complex of beta-galactosidase, cathepsin A, and neuraminidase. Possible implication for intralysosomal catabolism of keratan sulfate
J. Biol. Chem.
271
28359-28365
1996
Homo sapiens
Bielicki, J.; Fuller, M.; Guo, X.H.; Morris, P.; Hopwood, J.J.; Anson, D.S.
Expression, purification and characterization of recombinant human N-acetylgalactosmaine-6-sulphatase
Biochem. J.
311
333-339
1995
Homo sapiens
-
Masue, M.; Sukegawa, K.; Orii, T.; Hashimoto, T.
N-Acetylgalactosamine-6-sulfate sulfatase in human placenta: purification and characteristics
J. Biochem.
110
965-970
1991
Homo sapiens
Bielicki, J.; Hopwood, J.J.
Human liver N-acetylgalactosamine 6-sulphatase. Purification and characterization
Biochem. J.
279
515-520
1991
Homo sapiens
Tomatsu, S.; Fukuda, S.; Cooper, A.; Wraith, J.E.; Yamagishi, A.; Kato, Z.; Yamada, N.; Isogai, K.; Sukegawa, K.; Suzuki, Y.; Shimozawa, N.; Kondo, N.; Orii, T.
Fifteen polymorphisms in the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) gene: diagnostic implications in Morquio disease
Hum. Mutat.
Suppl. 1
S42-S46
1998
Homo sapiens
Cechowska-Pasko, M.; Wolanska, M.; Pallka, J.
Glycosaminoglycan-degrading enzymes in the skin of fasted rats
Comp. Biochem. Physiol. B
131
551-557
2002
Rattus norvegicus
Sukegawa, K.; Nakamura, H.; Kato, Z.; Tomatsu, S.; Montano, A.M.; Fukao, T.; Toietta, G.; Tortora, P.; Orii, T.; Kondo, N.
Biochemical and structural analysis of missense mutations in N-acetylgalactosamine-6-sulfate sulfatase causing mucopolysaccharidosis IVA phenotypes
Hum. Mol. Genet.
9
1283-1290
2000
Homo sapiens
Terzioglu, M.; Tokatli, A.; Coskun, T.; Emre, S.
Molecular analysis of Turkish mucopolysaccharidosis IVA (Morquio A) patients: identification of novel mutations in the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) gene
Hum. Mutat.
20
477-478
2002
Homo sapiens
Tomatsu, S.; Filocamo, M.; Orii, K.O.; Sly, W.S.; Gutierrez, M.A.; Nishioka, T.; Serrato, O.P.; Di Natale, P.; Montano, A.M.; Yamaguchi, S.; Kondo, N.; Orii, T.; Noguchi, A.
Mucopolysaccharidosis IVA (Morquio A): identification of novel common mutations in the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) gene in Italian patients
Hum. Mutat.
24
187-188
2004
Homo sapiens
de Assis, C.M.; Gandra, R.F.; Gambale, W.; Shimizu, M.T.; Paula, C.R.
Biosynthesis of chondroitinase and hyaluronidase by different strains of Paracoccidioides brasiliensis
J. Med. Microbiol.
52
479-481
2003
Paracoccidioides brasiliensis
Coutinho, S.D.; Paula, C.R.
Proteinase, phospholipase, hyaluronidase and chondroitin-sulphatase production by Malassezia pachydermatis
Med. Mycol.
38
73-76
2000
Malassezia pachydermatis
Laradi, S.; Tukel, T.; Khediri, S.; Shabbeer, J.; Erazo, M.; Chkioua, L.; Chaabouni, M.; Ferchichi, S.; Miled, A.; Desnick, R.J.
Mucopolysaccharidosis type IV: N-acetylgalactosamine-6-sulfatase mutations in Tunisian patients
Mol. Genet. Metab.
87
213-218
2006
Homo sapiens
Parkinson-Lawrence, E.J.; Muller, V.J.; Hopwood, J.J.; Brooks, D.A.
N-acetylgalactosamine-6-sulfatase protein detection in MPS IVA patient and unaffected control samples
Clin. Chim. Acta
377
88-91
2007
Homo sapiens (P34059), Homo sapiens
Bhattacharyya, S.; Kotlo, K.; Shukla, S.; Danziger, R.S.; Tobacman, J.K.
Distinct effects of N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase expression on chondroitin sulfates
J. Biol. Chem.
283
9523-9530
2008
Homo sapiens (P34059)
Tomatsu, S.; Vogler, C.; Montano, A.M.; Gutierrez, M.; Oikawa, H.; Dung, V.C.; Orii, T.; Noguchi, A.; Sly, W.S.
Murine model (Galns(tm(C76S)slu)) of MPS IVA with missense mutation at the active site cysteine conserved among sulfatase proteins
Mol. Genet. Metab.
91
251-258
2007
Mus musculus (Q571E4), Mus musculus
Tomatsu, S.; Montano, A.M.; Gutierrez, M.; Grubb, J.H.; Oikawa, H.; Dung, V.C.; Ohashi, A.; Nishioka, T.; Yamada, M.; Yamada, M.; Tosaka, Y.; Trandafirescu, G.G.; Orii, T.
Characterization and pharmacokinetic study of recombinant human N-acetylgalactosamine-6-sulfate sulfatase
Mol. Genet. Metab.
91
69-78
2007
Homo sapiens
Almeciga-Diaz, C.J.; Rueda-Paramo, M.A.; Espejo, A.J.; Echeverri, O.Y.; Montano, A.; Tomatsu, S.; Barrera, L.A.
Effect of elongation factor 1alpha promoter and SUMF1 over in vitro expression of N-acetylgalactosamine-6-sulfate sulfatase
Mol. Biol. Rep.
36
1863-1870
2008
Homo sapiens
Grinwis, M.E.; Sibley, C.D.; Parkins, M.D.; Eshaghurshan, C.S.; Rabin, H.R.; Surette, M.G.
Characterization of Streptococcus milleri group isolates from expectorated sputum of adult patients with cystic fibrosis
J. Clin. Microbiol.
48
395-401
2010
Streptococcus intermedius, Streptococcus constellatus, no activity in Streptococcus anginosus
Rodriguez, A.; Espejo, A.J.; Hernandez, A.; Velasquez, O.L.; Lizaraso, L.M.; Cordoba, H.A.; Sanchez, O.F.; Almeciga-Diaz, C.J.; Barrera, L.A.
Enzyme replacement therapy for MorquioA: an active recombinant N-acetylgalactosamine-6-sulfate sulfatase produced in Escherichia coli BL21
J. Ind. Microbiol. Biotechnol.
37
1193-1201
2010
Homo sapiens (P34059)
Yang, B.; Bhattacharyya, S.; Linhardt, R.; Tobacman, J.
Exposure to common food additive carrageenan leads to reduced sulfatase activity and increase in sulfated glycosaminoglycans in human epithelial cells
Biochimie
94
1309-1316
2012
Homo sapiens (P34059), Homo sapiens
Hernandez, A.; Velasquez, O.; Leonardi, F.; Soto, C.; Rodriguez, A.; Lizaraso, L.; Mosquera, A.; Bohorquez, J.; Coronado, A.; Espejo, A.; Sierra, R.; Sanchez, O.F.; Almeciga-Diaz, C.J.; Barrera, L.A.
Effect of culture conditions and signal peptide on production of human recombinant N-acetylgalactosamine-6-sulfate sulfatase in Escherichia coli BL21
J. Microbiol. Biotechnol.
23
689-698
2013
Homo sapiens (P34059), Homo sapiens
Feferman, L.; Bhattacharyya, S.; Birch, L.; Prins, G.S.; Tobacman, J.K.
Differential effects of estrogen exposure on arylsulfatase B, galactose-6-sulfatase, and steroid sulfatase in rat prostate development
J. Steroid Biochem. Mol. Biol.
143
105-114
2014
Rattus norvegicus (P50430)
Olarte-Avellaneda, S.; Rodriguez-Lopez, A.; Almeciga-Diaz, C.J.; Barrera, L.A.
Computational analysis of human N-acetylgalactosamine-6-sulfate sulfatase enzyme: an update in genotype-phenotype correlation for Morquio A
Mol. Biol. Rep.
41
7073-7088
2014
Homo sapiens (P34059), Homo sapiens
Egan, M.; Jiang, H.; OConnell Motherway, M.; Oscarson, S.; van Sinderen, D.
Glycosulfatase-encoding gene cluster in Bifidobacterium breve UCC2003
Appl. Environ. Microbiol.
82
6611-6623
2016
Bifidobacterium breve, Bifidobacterium breve UCC2003
Shams, S.; Barazandeh Tehrani, M.; Civallero, G.; Minookherad, K.; Giugliani, R.; Setoodeh, A.; Ashtiani, M.
Diagnosing mucopolysaccharidosis type IV a by the fluorometric assay of N-acetylgalactosamine-6-sulfate sulfatase activity
J. Diabetes Metab. Disord.
16
37
2017
Homo sapiens (P34059), Homo sapiens
Mashima, R.; Ohira, M.; Okuyama, T.; Tatsumi, A.
Quantification of the enzyme activities of iduronate-2-sulfatase, N-acetylgalactosamine-6-sulfatase and N-acetylgalactosamine-4-sulfatase using liquid chromatography-tandem mass spectrometry
Mol. Genet. Metab. Rep.
14
36-40
2018
Homo sapiens (P34059)
Bhattacharyya, S.; Feferman, L.; Tobacman, J.K.
Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3)
Oncotarget
8
242-260
2017
Homo sapiens (P34059), Homo sapiens
Matassini, C.; Vanni, C.; Goti, A.; Morrone, A.; Marradi, M.; Cardona, F.
Multimerization of DAB-1 onto Au GNPs affords new potent and selective N-acetylgalactosamine-6-sulfatase (GALNS) inhibitors
Org. Biomol. Chem.
16
8604-8612
2018
Homo sapiens (P34059)
Rodriguez-Lopez, A.; Almeciga-Diaz, C.J.; Sanchez, J.; Moreno, J.; Beltran, L.; Diaz, D.; Pardo, A.; Ramirez, A.M.; Espejo-Mojica, A.J.; Pimentel, L.; Barrera, L.A.
Recombinant human N-acetylgalactosamine-6-sulfate sulfatase (GALNS) produced in the methylotrophic yeast Pichia pastoris
Sci. Rep.
6
29329
2016
Homo sapiens (P34059), Homo sapiens
Reyes, L.; Cardona, C.; Pimentel, L.; Rodriguez-Lopez, A.; Almeciga-Diaz, C.
Improvement in the production of the human recombinant enzyme N-acetylgalactosamine-6-sulfatase (rhGALNS) in Escherichia coli using synthetic biology approaches
Sci. Rep.
7
5844
2017
Homo sapiens (P34059), Homo sapiens
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