3.1.3.7: 3'(2'),5'-bisphosphate nucleotidase
This is an abbreviated version!
For detailed information about 3'(2'),5'-bisphosphate nucleotidase, go to the full flat file.
Word Map on EC 3.1.3.7
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3.1.3.7
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phosphatidic
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1-phosphatase
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3'2',5'-bisphosphate
-
5'-phosphosulfate
-
3'-phosphoadenosine-5'-phosphate
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exoribonuclease
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lithium-sensitive
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medicine
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synthesis
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biotechnology
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pharmacology
- 3.1.3.7
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phosphatidic
-
1-phosphatase
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3'2',5'-bisphosphate
- 5'-phosphosulfate
- 3'-phosphoadenosine-5'-phosphate
- exoribonuclease
-
lithium-sensitive
- medicine
- synthesis
- biotechnology
- pharmacology
Reaction
Synonyms
3'(2'),5'-bisphosphate nucleotidase, 3'(2'),5'-bisphosphate nucleotidase 1, 3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase, 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase, 3'(2')-phosphoadenosine 5’-phosphate phosphatase, 3',5'-bisphosphate nucleotidase, 3'-PAPase, 3'-phosphoadenosine 5'-phosphate 3'-phosphatase, 3'-phosphoadenosine 5'-phosphate phosphatase, 3'-phosphoadenosine-5'-phosphatase, 3'-phosphoadenylylsulfate 3'-phosphatase, 3(2),5-bisphosphate nucleotidase, 3-phosphoadenosine 5-phosphate phosphatase, 3-phosphoadenosine-5-phosphatase, 3’-phosphoadenosine-5’-phosphatase, 3’-phosphoesterase, adenosine-3',5'-bisphosphate 3'-phosphohydrolase, AHL, bisphosphate 3'-nucleotidase, bisphosphate 3'-nucleotidase 1, BPNT-1, BPNT1, BPntase, Cv1693, CysQ, Dhal2p, DPNPase, FIERY1, GhHL1, gPAPP, Hal2, HalA, Halotolerance protein tol1, met22, MTCY270.37, NrnA, nucleotidase, phosphoadenylate 3'-, PAP 3'-phosphatase, PAP phosphatase, PAP-phosphatease, PAPase, PDE2, phosphoadenylate 3'-nucleotidase, Rv2131c, Rv2837c, Yeast 3',5'-bisphosphate nucleotidase, YND
ECTree
3.1.3.7 3'(2'),5'-bisphosphate nucleotidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.1.3.7 - 3'(2'),5'-bisphosphate nucleotidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxyguanosine 3',5'-bisphosphate + H2O
2'-deoxyguanosine 5'-phosphate + phosphate
-
-
-
?
2'-deoxythymidine 3',5'-bisphosphate + H2O
2'-deoxythymidine 5'-phosphate + phosphate
-
-
-
?
2'-deoxyuridine 3',5'-bisphosphate + H2O
2'-deoxyuridine 5'-phosphate + phosphate
-
-
-
?
3'-phosphoadenosine 5'-phosphate + H2
AMP + phosphate
-
-
-
?
5'-phosphoadenylyl-(3'->5')-adenosine + H2O
? + phosphate
-
-
-
?
cytidine 3',5'-bisphosphate + H2O
cytidine 5'-phosphate + phosphate
-
-
-
?
D-myo-inositol 2-phosphate + H2O
D-myo-inositol + phosphate
-
9% relative activity compared to NADP+
-
-
?
D-myo-inositol-1,4,5-trisphosphate + H2O
?
-
14% relative activity compared to NADP+
-
-
?
D-myo-inositol-1,4-bisphosphate + H2O
?
-
485% relative activity compared to NADP+
-
-
?
guanosine 2',5'-bisphosphate + H2O
guanosine 2'-phosphate + phosphate
-
-
-
?
N6-methyl-5'-phosphoadenylyl-(3'->5')-adenosine + H2O
? + phosphate
-
-
-
?
NADPH + H2O
NADH + phosphate
-
145% relative activity compared to NADP+
-
-
?
p-nitrophenyl phosphate
p-nitrophenol + phosphate
-
21% relative activity compared to NADP+
-
-
?
thymidine 3',5'-bisphosphate + H2O
thymidine 5'-phosphate + phosphate
-
-
-
?
uridine 3',5'-bisphosphate + H2O
uridine 5'-phosphate + phosphate
-
-
-
?
2'-deoxyadenosine 3',5'-bisphosphate + H2O
2'-deoxyadenosine 5'-phosphate + phosphate
-
-
-
?
2'-deoxyadenosine 3',5'-bisphosphate + H2O
2'-deoxyadenosine 5'-phosphate + phosphate
-
-
-
?
2'-deoxycytidine 3',5'-bisphosphate + H2O
2'-deoxycytidine 5'-phosphate + phosphate
-
-
-
?
2'-deoxycytidine 3',5'-bisphosphate + H2O
2'-deoxycytidine 5'-phosphate + phosphate
-
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
67% enzyme activity in comparison to 3'-phosphoadenosine 5'-phosphate as substrate
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
829% relative activity compared to NADP+
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
100% in comparison to 3'-phosphoadenosine 5'-phosphate as substrate
-
?
adenosine 2',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
only 6% enzyme activity in comparison to 3'-phosphoadenosine 5'-phosphate as substrate
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
100% activity
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
607% relative activity compared to NADP+
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
the activity of enzyme is required while 3'-phosphoadenosine 5'-phosphate is a potent inhibitor of a variety of enzymes that use 3'-phosphoadenosine 5'-phosphate as cosubstrate
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
best substrate
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
best substrate
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
adenosine 5'-phosphate + phosphate
-
-
?
adenosine 3',5'-bisphosphate + H2O
AMP + phosphate
i.e. PAP
-
-
?
adenosine 3',5'-bisphosphate + H2O
AMP + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
AMP + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate + H2O
AMP + phosphate
i.e. PAP
-
-
?
adenosine 3',5'-bisphosphate + H2O
AMP + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate sulfate + H2O
adenosine 5'-phosphate sulfate + phosphate
-
-
-
?
adenosine 3',5'-bisphosphate sulfate + H2O
adenosine 5'-phosphate sulfate + phosphate
-
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
42% activity compared to adenosine 3',5'bisphosphate
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
-
?
adenosine 3'-phosphate 5'-phosphosulfate + H2O
adenosine 5'-phosphosulfate + phosphate
-
-
-
?
D-fructose 1,6-bisphosphate + H2O
?
-
122% relative activity compared to NADP+
-
-
?
D-myo-inositol monophosphate + H2O
D-myo-inositol + phosphate
-
13% relative activity compared to NADP+
-
-
?
D-myo-inositol monophosphate + H2O
D-myo-inositol + phosphate
-
-
-
?
D-myo-inositol monophosphate + H2O
D-myo-inositol + phosphate
-
-
-
?
guanosine 3',5'-bisphosphate + H2O
guanosine 5'-phosphate + phosphate
-
-
-
?
guanosine 3',5'-bisphosphate + H2O
guanosine 5'-phosphate + phosphate
-
-
-
?
guanosine 3',5'-bisphosphate + H2O
guanosine 5'-phosphate + phosphate
-
-
-
?
inositol 1,3,4-trisphosphate + H2O
inositol 3,4-bisphosphate + phosphate
-
-
-
-
?
inositol 1,3,4-trisphosphate + H2O
inositol 3,4-bisphosphate + phosphate
-
-
?
inositol 1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
-
-
?
inositol 1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
?
inositol 1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
-
?
inositol 1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
?
inositol-1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
5.6% activity compared to adenosine 3',5'bisphosphate
-
-
?
inositol-1,4-bisphosphate + H2O
inositol 4-phosphate + phosphate
-
-
?
additional information
?
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enzyme is promiscuous and is able to hydrolyze several 3',5'-bisphosphonucleotides such as pGp, pCp, pUp, and pIp, and 2'-deoxynucleotides with comparable catalytic efficiency. In addition, it is capable of hydrolyzing short oligonucleotides such as (pdA)5, albeit at rates much lower than that of adenosine 3',5'-bisphosphate
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-
?
additional information
?
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-
enzyme is promiscuous and is able to hydrolyze several 3',5'-bisphosphonucleotides such as pGp, pCp, pUp, and pIp, and 2'-deoxynucleotides with comparable catalytic efficiency. In addition, it is capable of hydrolyzing short oligonucleotides such as (pdA)5, albeit at rates much lower than that of adenosine 3',5'-bisphosphate
-
-
?
additional information
?
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enzyme is promiscuous and is able to hydrolyze several 3',5'-bisphosphonucleotides such as pGp, pCp, pUp, and pIp, and 2'-deoxynucleotides with comparable catalytic efficiency. In addition, it is capable of hydrolyzing short oligonucleotides such as (pdA)5, albeit at rates much lower than that of adenosine 3',5'-bisphosphate
-
-
?
additional information
?
-
-
glycerol phosphate, D-glucose-1-phosphate, D-glucose-6-phosphate, D-fructose-1-phosphate, D-fructose 1,6-bisphosphate, D-fructose-6-phosphate, ADP, 5'-AMP, ATP, NAD+, NMN+, bis-p-nitrophenol phosphate are no substrates
-
-
?
additional information
?
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GhHL1 protein efficiently hydrolyzes 3'(2'),5'-bisphosphate nucleotide and 3'(2'),5'-bisphosphate nucleotide sulfate, at 128% of 3'(2'),5'-bisphosphate nucleotide levels, but has low or no activity with other tested compounds including 3'-AMP, 5'-AMP, or ADP. Purified recombinant GhHL1 protein dephosphorylates both 3',5'-bisphosphate nucleotide and inositol 1,4-bisphosphate, demonstrating dual 3',5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase activities, substrate specificity, overview
-
-
?
additional information
?
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-
GhHL1 protein efficiently hydrolyzes 3'(2'),5'-bisphosphate nucleotide and 3'(2'),5'-bisphosphate nucleotide sulfate, at 128% of 3'(2'),5'-bisphosphate nucleotide levels, but has low or no activity with other tested compounds including 3'-AMP, 5'-AMP, or ADP. Purified recombinant GhHL1 protein dephosphorylates both 3',5'-bisphosphate nucleotide and inositol 1,4-bisphosphate, demonstrating dual 3',5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase activities, substrate specificity, overview
-
-
?
additional information
?
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GhHL1 protein efficiently hydrolyzes 3'(2'),5'-bisphosphate nucleotide and 3'(2'),5'-bisphosphate nucleotide sulfate, at 128% of 3'(2'),5'-bisphosphate nucleotide levels, but has low or no activity with other tested compounds including 3'-AMP, 5'-AMP, or ADP. Purified recombinant GhHL1 protein dephosphorylates both 3',5'-bisphosphate nucleotide and inositol 1,4-bisphosphate, demonstrating dual 3',5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase activities, substrate specificity, overview
-
-
?
additional information
?
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3'-phosphoadenosine 5'-phosphate 3'-phosphatase plays a role in the formation of skeletal elements derived through endochondral ossification
-
-
?
additional information
?
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enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60
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-
?
additional information
?
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enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60
-
-
?
additional information
?
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Mtb CysQ can dephosphorylate myo-inositol 1-phosphate (IMP), fructose 1,6-bisphosphate (FBP), and 3'-phosphoadenosine 5'-monophosphate (PAP), but the catalytic efficiency is 1700 and 15000fold greater for PAP over FBP and IMP, respectively. AMP and phosphate enzyme binding structures, overview. The specificity of a 5'-phosphate or bis-phosphate sugars for CysQ can likely come from a conserved positively charged residue, Lys190 in CysQ, that ion pairs with the nonhydrolyzed phosphate
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-
?
additional information
?
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-
Mtb CysQ can dephosphorylate myo-inositol 1-phosphate (IMP), fructose 1,6-bisphosphate (FBP), and 3'-phosphoadenosine 5'-monophosphate (PAP), but the catalytic efficiency is 1700 and 15000fold greater for PAP over FBP and IMP, respectively. AMP and phosphate enzyme binding structures, overview. The specificity of a 5'-phosphate or bis-phosphate sugars for CysQ can likely come from a conserved positively charged residue, Lys190 in CysQ, that ion pairs with the nonhydrolyzed phosphate
-
-
?
additional information
?
-
enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60
-
-
?
additional information
?
-
Mtb CysQ can dephosphorylate myo-inositol 1-phosphate (IMP), fructose 1,6-bisphosphate (FBP), and 3'-phosphoadenosine 5'-monophosphate (PAP), but the catalytic efficiency is 1700 and 15000fold greater for PAP over FBP and IMP, respectively. AMP and phosphate enzyme binding structures, overview. The specificity of a 5'-phosphate or bis-phosphate sugars for CysQ can likely come from a conserved positively charged residue, Lys190 in CysQ, that ion pairs with the nonhydrolyzed phosphate
-
-
?
additional information
?
-
adenosine 3',5'-bisphosphate is not the primary substrate, the enzyme may be important for response to salt stress
-
-
?
additional information
?
-
-
adenosine 3',5'-bisphosphate is not the primary substrate, the enzyme may be important for response to salt stress
-
-
?
additional information
?
-
isoform additonally hydrolyses cyclic di-AMP, reaction of EC 3.1.4.59. No substrate: ATP
-
-
?
additional information
?
-
isoform additonally hydrolyses cyclic di-AMP, reaction of EC 3.1.4.59. No substrate: ATP
-
-
?
additional information
?
-
not: 3Â’-AMP, ATP, NADP, O-phospho-L-serine, phosphoglycolic acid, L-histidinol phosphate
-
?
