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Literature summary for 3.1.3.7 extracted from

  • Meisel, J.D.; Kim, D.H.
    Inhibition of lithium-sensitive phosphatase BPNT-1 causes selective neuronal dysfunction in C. elegans (2016), Curr. Biol., 26, 1922-1928 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.7

Protein Variants

Protein Variants Comment Organism
additional information usage of CRISPR/Cas9-mediated genome editing to generate a loss-of-function bpnt-1 allele, qd303, in which a deletion/insertion leads to a frameshift at amino acid 20 followed by a premature stop codon. bpnt-1 mRNA is almost entirely absent in the bpnt-1(qd303) mutant, demonstrating that the bpnt-1 expression pattern is specific. Animals carrying bpnt-1(qd303), or the W294X nonsense mutation bpnt-1(gk469190), fail to express daf-7 in the ASJ neurons when exposed to Pseudomonas aeruginosa. Notably, the constitutive expression of daf-7 in the ASI neuron pair is unaffected by loss of bpnt-1. BPNT-1 is required for the expression of daf-7 specifically in the ASJ neurons Caenorhabditis elegans

Inhibitors

Inhibitors Comment Organism Structure
Li+ a lithium-sensitive enzyme, the ASJ neurons are selectively and reversibly inhibited by lithium, molecular mechanism by which loss of BPNT-1 leads to dysfunction of the ASJ neuron, overview Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Caenorhabditis elegans 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenosine 3',5'-bisphosphate + H2O Caenorhabditis elegans
-
 AMP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans Q23493
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Caenorhabditis elegans
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neuron ASJ neurons Caenorhabditis elegans
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 3',5'-bisphosphate + H2O
-
 Caenorhabditis elegans AMP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
bisphosphate 3'-nucleotidase
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 Caenorhabditis elegans
BPNT-1
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 Caenorhabditis elegans

General Information

General Information Comment Organism
evolution BPNT-1 is conserved in all eukaryotes, and belongs to a family of lithium-sensitive phosphatases that includes inositol monophosphatase and inositol polyphosphate-1-phosphatase Caenorhabditis elegans
malfunction loss of BPNT-1 in Caenorhabditis elegans results in the selective dysfunction two neurons, the bilaterally symmetric pair of ASJ chemosensory neurons. As a result, BPNT-1 mutants are defective in behaviors dependent on the ASJ neurons, such as dauer exit and pathogen avoidance. Acute treatment with lithium also causes dysfunction of the ASJ neurons. This effect is reversible, and mediated specifically through inhibition of BPNT-1. The selective effect of lithium on the nervous system is due in part to the limited expression of the cytosolic sulfotransferase SSU-1 in the ASJ neuron pair. Lithium, through inhibition of BPNT-1 in the nervous system, can cause selective toxicity to specific neurons, resulting in corresponding effects on behavior of Caenorhabditis elegans, molecular mechanism by which loss of BPNT-1 leads to dysfunction of the ASJ neuron, bpnt-1 phenotypes, overview. The specific expression of the cytosolic sulfotransferase SSU-1 in the ASJ neuron pair may contribute to the selective neuronal dysfunction caused by loss of BPNT-1 Caenorhabditis elegans
physiological function bisphosphate 3'-nucleotidase (BPNT-1) is a lithium-sensitive phosphatase that catalyzes the breakdown of cytosolic 3'-phosphoadenosine-5'-phosphate (PAP), a byproduct of sulfation reactions utilizing the universal sulfate group donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS). The daf-7 gene encodes a TGF-beta ligand that regulates diverse behaviors Caenorhabditis elegans and is transcriptionally activated in the ASJ chemosensory neuron pair upon exposure to the pathogenic bacteria Pseudomonas aeruginosa. BPNT-1 is required for the expression of daf-7 specifically in the ASJ neurons Caenorhabditis elegans