Literature summary for 3.1.3.7 extracted from

Manikandan, K.; Sabareesh, V.; Singh, N.; Saigal, K.; Mechold, U.; Sinha, K.
Two-step synthesis and hydrolysis of cyclic di-AMP in Mycobacterium tuberculosis (2014), PLoS ONE, 9, e86096 .

Search for more literature for 3.1.3.7

Cloned(Commentary)

Cloned (Comment)	Organism
exprerssion in Escherichia coli	Mycobacterium tuberculosis

Protein Variants

Protein Variants	Comment	Organism
D130A/H131A	mutant fails to hydrolyze c-di-AMP	Mycobacterium tuberculosis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
soluble	-	Mycobacterium tuberculosis	-	-

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P71615	bifunctional oligoribonuclease and PAP phosphatase, enzyme has a DHH/DHHA1 domein	-
Mycobacterium tuberculosis H37Rv	P71615	bifunctional oligoribonuclease and PAP phosphatase, enzyme has a DHH/DHHA1 domein	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
adenosine 3',5'-bisphosphate + H2O	-	Mycobacterium tuberculosis	AMP + phosphate	-	?
adenosine 3',5'-bisphosphate + H2O	-	Mycobacterium tuberculosis H37Rv	AMP + phosphate	-	?
additional information	enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60	Mycobacterium tuberculosis	?	-	?
additional information	enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60	Mycobacterium tuberculosis H37Rv	?	-	?

Synonyms

Synonyms	Comment	Organism
NrnA	-	Mycobacterium tuberculosis
Rv2837c	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)