3.1.3.7: 3'(2'),5'-bisphosphate nucleotidase
This is an abbreviated version!
For detailed information about 3'(2'),5'-bisphosphate nucleotidase, go to the full flat file.
Word Map on EC 3.1.3.7
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3.1.3.7
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phosphatidic
-
1-phosphatase
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3'2',5'-bisphosphate
-
5'-phosphosulfate
-
3'-phosphoadenosine-5'-phosphate
-
exoribonuclease
-
lithium-sensitive
-
medicine
-
synthesis
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biotechnology
-
pharmacology
- 3.1.3.7
-
phosphatidic
-
1-phosphatase
-
3'2',5'-bisphosphate
- 5'-phosphosulfate
- 3'-phosphoadenosine-5'-phosphate
- exoribonuclease
-
lithium-sensitive
- medicine
- synthesis
- biotechnology
- pharmacology
Reaction
Synonyms
3'(2'),5'-bisphosphate nucleotidase, 3'(2'),5'-bisphosphate nucleotidase 1, 3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase, 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase, 3'(2')-phosphoadenosine 5’-phosphate phosphatase, 3',5'-bisphosphate nucleotidase, 3'-PAPase, 3'-phosphoadenosine 5'-phosphate 3'-phosphatase, 3'-phosphoadenosine 5'-phosphate phosphatase, 3'-phosphoadenosine-5'-phosphatase, 3'-phosphoadenylylsulfate 3'-phosphatase, 3(2),5-bisphosphate nucleotidase, 3-phosphoadenosine 5-phosphate phosphatase, 3-phosphoadenosine-5-phosphatase, 3’-phosphoadenosine-5’-phosphatase, 3’-phosphoesterase, adenosine-3',5'-bisphosphate 3'-phosphohydrolase, AHL, bisphosphate 3'-nucleotidase, bisphosphate 3'-nucleotidase 1, BPNT-1, BPNT1, BPntase, Cv1693, CysQ, Dhal2p, DPNPase, FIERY1, GhHL1, gPAPP, Hal2, HalA, Halotolerance protein tol1, met22, MTCY270.37, NrnA, nucleotidase, phosphoadenylate 3'-, PAP 3'-phosphatase, PAP phosphatase, PAP-phosphatease, PAPase, PDE2, phosphoadenylate 3'-nucleotidase, Rv2131c, Rv2837c, Yeast 3',5'-bisphosphate nucleotidase, YND
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Reference on EC 3.1.3.7 - 3'(2'),5'-bisphosphate nucleotidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lik-Shing Tsang, M.; Schiff, J.A.
Properties of enzyme fraction A from Chlorella and copurification of 3 (2 ), 5-biphosphonucleoside 3 (2 )-phosphohydrolase, adenosine 5 phosphosulfate sulfohydrolase and adenosine-5-phosphosulfate cyclase activities
Eur. J. Biochem.
65
113-121
1976
Auxenochlorella pyrenoidosa
Brunngraber, E.G.
Nucleotides involved in the enzymatic conjugation of phenols with sulfate
J. Biol. Chem.
233
472-477
1958
Oryctolagus cuniculus
Quintero, F.J.; Garciadeblas, B.; Rodriguez-Navarro, A.
The SAL1 gene of Arabidopsis, encoding an enzyme with 3 (2 ),5-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase activities, increases salt tolerance in yeast
Plant Cell
8
529-537
1996
Arabidopsis thaliana
Peng, Z.; Verma, D.P.S.
A rice HAL2-like gene encodes a Ca(2+)-sensitive 3 (2 ),5-diphosphonucleoside 3 (2 )-phosphohydrolase and complements yeast met22 and Escherichia coli cysQ mutations
J. Biol. Chem.
270
29105-29110
1995
Oryza sativa (P0C5A3), Oryza sativa
Spiegelberg, B.D.; Xiong, J.P.; Smith, J.J.; Gu, R.F.; York, J.D.
Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3-nucleotidase inhibited by inositol 1,4-bisphosphate
J. Biol. Chem.
274
13619-13628
1999
Homo sapiens (O95861), Homo sapiens, Mus musculus (Q9Z0S1), Mus musculus
Ribeiro, J.M.; Ruiz, A.; Sillero, A.; Sillero, M.G.
A low Km nucleoside 3 (2 ),5-bisphosphate 3 (2 )-phosphohydrolase from rat liver
Biochimie
72
227-234
1990
Rattus norvegicus
Murguia, J.R.; Belles, J.M.; Serrano, R.
A salt-sensitive 3 (2 ),5-bisphosphate nucleotidase involved in sulfate activation
Science
267
232-234
1995
Saccharomyces cerevisiae, Solanum lycopersicum
Yenush, L.; Belles, J.M.; Lopez-Coronado, J.M.; Gil-Mascarell, R.; Serrano, R.; Rodriguez, P.L.
A novel target of lithium therapy
FEBS Lett.
467
321-325
2000
Homo sapiens (O95861), Homo sapiens
Miyamoto, R.; Sugiura, R.; Kamitani, S.; Yada, T.; Lu, Y.; Sio, S.O.; Asakura, M.; Matsuhisa, A.; Shuntoh, H.; Kuno, T.
Tol1, a fission yeast phosphomonoesterase, is an in vivo target of lithium, and its deletion leads to sulfite auxotrophy
J. Bacteriol.
182
3619-3625
2000
Schizosaccharomyces pombe
Betti, M.; Petrucco, S.; Bolchi, A.; Dieci, G.; Ottonello, S.
A plant 3'-phosphoesterase involved in the repair of DNA strand breaks generated by oxidative damage
J. Biol. Chem.
276
18038-18045
2001
Arabidopsis thaliana (Q84JE8), Zea mays (Q94FY6), Zea mays (Q94G04), Drosophila melanogaster (Q9VHS0)
Patel, S.; Martinez-Ripoll, M.; Blundell, T.L.; Albert, A.
Structural enzymology of Li(+)-sensitive/Mg(2+)-dependent phosphatases
J. Mol. Biol.
320
1087-1094
2002
Saccharomyces cerevisiae (P32179)
Aggarwal, M.; Mondal, A.K.
Role of N-terminal hydrophobic region in modulating the subcellular localization and enzyme activity of the bisphosphate nucleotidase from Debaryomyces hansenii
Eukaryot. Cell
5
262-271
2006
Debaryomyces hansenii
Spiegelberg, B.D.; Dela Cruz, J.; Law, T.H.; York, J.D.
Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism
J. Biol. Chem.
280
5400-5405
2005
Homo sapiens
Zhang, J.Y.; Zou, J.; Bao, Q.; Chen, W.L.; Wang, L.; Yang, H.; Zhang, C.C.
A lithium-sensitive and sodium-tolerant 3-phosphoadenosine-5-phosphatase encoded by halA from the cyanobacterium Arthrospira platensis is closely related to its counterparts from yeasts and plants
Appl. Environ. Microbiol.
72
245-251
2006
Arthrospira platensis (Q3LS17), Arthrospira platensis
Fukuda, C.; Kawai, S.; Murata, K.
NADP(H) phosphatase activities of archaeal inositol monophosphatase and eubacterial 3-phosphoadenosine 5-phosphate phosphatase
Appl. Environ. Microbiol.
73
5447-5452
2007
Escherichia coli
Aggarwal, M.; Kishan, K.V.; Mondal, A.K.
Creation of salt-insensitive 3(2),5-bisphosphate nucleotidase by modeling and mutagenesis approach
Arch. Biochem. Biophys.
469
174-183
2008
Debaryomyces hansenii
Cheong, J.J.; Hwang, I.; Rhee, S.; Moon, T.W.; Choi, Y.D.; Kwon, H.B.
Complementation of an E. coli cysteine auxotrophic mutant for the structural modification study of 3(2),5-bisphosphate nucleotidase
Biotechnol. Lett.
29
913-918
2007
Arabidopsis thaliana (Q38945)
Frederick, J.P.; Tafari, A.T.; Wu, S.M.; Megosh, L.C.; Chiou, S.T.; Irving, R.P.; York, J.D.
A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation
Proc. Natl. Acad. Sci. USA
105
11605-11612
2008
Mus musculus (Q80V26)
Hatzios, S.K.; Iavarone, A.T.; Bertozzi, C.R.
Rv2131c from Mycobacterium tuberculosis is a CysQ 3'-phosphoadenosine-5'-phosphatase
Biochemistry
47
5823-5831
2008
Mycobacterium tuberculosis (P9WKJ1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKJ1)
Lu, S.Y.; Zhao, G.R.; Wu, A.M.; Jenks, M.A.; Zhang, S.; Liu, J.Y.
Molecular cloning of a cotton phosphatase gene and its functional characterization
Biochemistry (Moscow)
75
85-94
2010
Gossypium hirsutum (Q8VWZ6), Gossypium hirsutum, Gossypium hirsutum CRI 12 (Q8VWZ6)
Kim, B.H.; von Arnim, A.G.
FIERY1 regulates light-mediated repression of cell elongation and flowering time via its 3(2),5-bisphosphate nucleotidase activity
Plant J.
58
208-219
2009
Arabidopsis thaliana (Q42546)
Hudson, B.H.; York, J.D.
Tissue-specific regulation of 3-nucleotide hydrolysis and nucleolar architecture
Adv. Biol. Regul.
54
208-213
2014
Mus musculus (Q9Z0S1)
Cummings, J.A.; Vetting, M.; Ghodge, S.V.; Xu, C.; Hillerich, B.; Seidel, R.D.; Almo, S.C.; Raushel, F.M.
Prospecting for unannotated enzymes: discovery of a 3',5'-nucleotide bisphosphate phosphatase within the amidohydrolase superfamily
Biochemistry
53
591-600
2014
Chromobacterium violaceum (Q7NXD4), Chromobacterium violaceum, Chromobacterium violaceum DSM 30191 (Q7NXD4)
Hudson, B.H.; Frederick, J.P.; Drake, L.Y.; Megosh, L.C.; Irving, R.P.; York, J.D.
Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis
Proc. Natl. Acad. Sci. USA
110
5040-5045
2013
Mus musculus (Q9Z0S1), Mus musculus
Yang, Y.; Ma, J.; Yang, Y.; Zhang, X.; Wang, Y.; Yang, L.; Sun, M.
Yeast 3,5-bisphosphate nucleotidase: an affinity tag for protein purification
Protein Expr. Purif.
97
81-87
2014
Saccharomyces cerevisiae (P32179), Saccharomyces cerevisiae
Erickson, A.I.; Sarsam, R.D.; Fisher, A.J.
Crystal structures of Mycobacterium tuberculosis CysQ, with substrate and products Bound
Biochemistry
54
6830-6841
2015
Mycobacterium tuberculosis (P9WKJ1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKJ1)
Meisel, J.D.; Kim, D.H.
Inhibition of lithium-sensitive phosphatase BPNT-1 causes selective neuronal dysfunction in C. elegans
Curr. Biol.
26
1922-1928
2016
Caenorhabditis elegans (Q23493), Caenorhabditis elegans
Bowman, L.; Zeden, M.S.; Schuster, C.F.; Kaever, V.; Gruendling, A.
New insights into the cyclic di-adenosine monophosphate (c-di-AMP) degradation pathway and the requirement of the cyclic dinucleotide for acid stress resistance in Staphylococcus aureus
J. Biol. Chem.
291
26970-26986
2016
Staphylococcus aureus (A0A0H2XFX6), Staphylococcus aureus USA300 (A0A0H2XFX6)
Liu, Y.; Sun, M.-H.; Shao, S.-K.; Deng, G.
An affinity-based aqueous two-phase mixed micellar system and its purification of yeast 3',5'-bisphosphate nucleotidase
J. Chromatogr. B
1060
215-220
2017
Saccharomyces cerevisiae (P32179), Saccharomyces cerevisiae
Manikandan, K.; Sabareesh, V.; Singh, N.; Saigal, K.; Mechold, U.; Sinha, K.
Two-step synthesis and hydrolysis of cyclic di-AMP in Mycobacterium tuberculosis
PLoS ONE
9
e86096
2014
Mycobacterium tuberculosis (P71615), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P71615)
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