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0.0068
(2E)-1-(3-aminophenyl)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0062
(2E)-1-(4-aminophenyl)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0029
(2E)-1-[3-(benzyloxy)phenyl]-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0026
(2E)-3-(5-bromo-2,4-dihydroxyphenyl)-1-[4-methoxy-3-(3-methylbut-3-en-2-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0111
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-(3-methoxyphenyl)prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0113
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-(3-[[(methoxycarbonyl)sulfanyl]amino]phenyl)prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0042
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-(4-butoxyphenyl)prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0137
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0099
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0139
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[2-(dimethylamino)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0068
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[2-(piperidin-1-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0035
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[2-[di(prop-2-en-1-yl)amino]phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.007
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[3-(3-methylbut-3-en-2-yl)-4-[(3-methylbut-2-en-1-yl)oxy]phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0264
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[3-(dimethylamino)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0049
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[3-(piperidin-1-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0045
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[3-[di(prop-2-en-1-yl)amino]phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.006
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-(1H-pyrazol-1-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.03
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-(dimethylamino)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0184
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-(methylsulfonyl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.008
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-(morpholin-4-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0026
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-(piperidin-1-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0044
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0053
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-3-en-2-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0044
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(prop-2-en-1-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0029
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0019
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-methoxy-3-(3-methylbut-3-en-2-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0053
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-methoxy-3-(prop-2-en-1-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0035
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-[(3-methylbut-2-en-1-yl)oxy]phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0027
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-[(4-methylphenyl)sulfonyl]phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0034
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-[di(prop-2-en-1-yl)amino]phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0063
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[6-(dimethylamino)-1,3-benzodioxol-5-yl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0029
(2E)-3-[5-bromo-2-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-1-[4-methoxy-3-(3-methylbut-3-en-2-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.0103
(2E)-3-[5-bromo-2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-1-[4-hydroxy-3-(3-methylbut-3-en-2-yl)phenyl]prop-2-en-1-one
-
pH not specified in the publication, temperature not specified in the publication
0.22
(3S,6S,9R)-3,6-dimethyl-9-[(R)-phenyl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione
-
pH 7.5, 25°C
0.199
(3S,6S,9R,12R)-3,6,9-trimethyl-12-[(R)-phenyl(phenylamino)methyl]-1,4,7,10-tetraazacyclotridecane-2,5,8,11-tetrone
-
pH 7.5, 25°C
0.008
(3S,9R)-3-(4-hydroxybenzyl)-9-[(R)-phenyl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione
-
pH 7.5, 25°C
0.023 - 0.1
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
0.0003 - 0.113
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
0.14
(6R)-6-[(R)-phenyl(phenylamino)methyl]-1,4-diazepane-2,5-dione
-
pH 7.5, 25°C
0.215
(9R)-9-[(R)-furan-2-yl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione
-
pH 7.5, 25°C
0.0855
(9R)-9-[(R)-phenyl(phenylamino)methyl]-1,4,7-triazecane-2,5,8-trione
-
pH 7.5, 25°C
0.0497
(difluoro[4-[(2,2,2-trifluoroethyl)carbamoyl]phenyl]methyl)phosphonic acid
pH 6.2, 37°C
0.1
(difluoro[4-[(2-fluorophenyl)carbamoyl]phenyl]methyl)phosphonic acid
above, pH 6.2, 37°C
0.0616
(difluoro[4-[(2-phenylethyl)carbamoyl]phenyl]methyl)phosphonic acid
pH 6.2, 37°C
0.0418
(difluoro[4-[(3-fluorophenyl)carbamoyl]phenyl]methyl)phosphonic acid
pH 6.2, 37°C
0.0227
(difluoro[4-[(4-fluorophenyl)carbamoyl]phenyl]methyl)phosphonic acid
pH 6.2, 37°C
0.1
(difluoro[4-[(phenylamino)methyl]phenyl]methyl)phosphonic acid
above, pH 6.2, 37°C
0.1
(difluoro[4-[2-oxo-2-(phenylamino)ethyl]phenyl]methyl)phosphonic acid
above, pH 6.2, 37°C
0.1
(difluoro[4-[methyl(phenyl)carbamoyl]phenyl]methyl)phosphonic acid
above, pH 6.2, 37°C
0.01
16alphaH,17-isovaleryloxy-ent-kauran-19-oic acid
-
pH 6.0, 30°C
0.019 - 0.109
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
0.00091 - 0.115
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
0.00061 - 0.147
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
0.00019 - 0.0038
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
0.00017 - 0.088
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
2 - 81
2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid
0.0042
2-[6-chloro-5-(1-naphthalyloxy)-1H-benzimidazol-2-yl]thio-N-(thiazol-2-yl)acetamide
pH 7.0, 37°C
2.5
3-(1-carboxy-ethoxy)-6-chloro-benzo(b)-thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.052
3-(carboxy-fluoro-methoxy)-6-chloro-benzo(b)thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.86
3-(carboxymethoxy)-2-naphthoic acid
-
pH 7.0, 22°C
0.00092
3-(carboxymethoxy)-5-((cyclohexylmethyl)-amino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.0017
3-(carboxymethoxy)-5-(cyclohexylamino)-thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.01
3-(carboxymethoxy)-5-chlorothieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.0016
3-(carboxymethoxy)-6-((1-(ethylsulfonyl)-piperidin-4-yl)amino)thieno(3,2-b)(1)benzo-thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.00068
3-(carboxymethoxy)-6-((cyclohexylmethyl)-amino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.00074
3-(carboxymethoxy)-6-(cyclohexylamino)-thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.0024
3-(carboxymethoxy)-6-(tetrahydro-2H-pyran-4-ylamino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.035
3-(carboxymethoxy)-6-chlorothieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
pH 7.0, 22°C
2.5
3-(carboxymethoxy)-6-methylthieno(3,2-c)pyridine-2-carboxylic acid
-
pH 7.0, 22°C
0.16
3-(carboxymethoxy)benzo(b)thiophene-2-carboxylic acid
-
pH 7.0, 22°C
2.5
3-(carboxymethoxy)furo(2,3-b)pyridine-2-carboxylic acid
-
pH 7.0, 22°C
0.2 - 0.23
3-(carboxymethoxy)thieno(2,3-b)pyridine-2-carboxylic acid
0.0092
3-(carboxymethoxy)thieno(3,2-b)(1)benzo-thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.077
3-(carboxymethoxy)thieno(3,2-b)pyridine-2-carboxylic acid
-
pH 7.0, 22°C
0.28
3-(carboxymethoxy)thieno(3,2-b)thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.026
3-carboxymethoxy-6-(4-hydroxyphenyl)-benzo(b)-thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.02
3-carboxymethoxy-6-(5-methyl-1-phenyl-1H-pyrazol-3-ylcarbamoyl)-benzo(b)thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.061
3-carboxymethoxy-6-chloro-benzo(b)-thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.128
3-carboxymethoxy-6-phenylbenzo(b)-thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.03
3-carboxymethoxy-6-thiophen-2-yl-benzo(b)-thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.119
3-carboxymethoxy-7-chloro-benzo(b)-thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.037
3-carboxymethoxy-7-methyl-benzo(b)-thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.011
3-carboxymethoxy-naphtho(1,2-b)thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.5
3-carboxymethoxy-thieno(3,2-c)quinoline-2-carboxylic acid
-
pH 7.0, 22°C
0.0216
3-[2,5-dimethyl-3-[(3-oxo-2,3-dihydro[1,3]thiazolo[3,2-a]benzimidazol-2-yl)methyl]-1H-pyrrol-1-yl]benzoic acid
pH 7.0, 25°C
0.000026
4-(difluoro(phosphono)methyl)-N-pentadecanoyl-L-phenylalanyl-L-a-aspartyl-4-(difluoro(phosphono)methyl)-L-phenylalaninamide
-
-
0.0023
4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenyl 4-bromobenzoate
-
pH not specified in the publication, temperature not specified in the publication
0.0024
4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenyl 4-tert-butylbenzoate
-
pH not specified in the publication, temperature not specified in the publication
0.0049
4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenyl benzoate
-
pH not specified in the publication, temperature not specified in the publication
0.03
4-[4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenoxy]butanoic acid
-
pH not specified in the publication, temperature not specified in the publication
0.1
4-[difluoro(phosphono)methyl]benzoic acid
above, pH 6.2, 37°C
0.0052
5-chloro-N-[6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazol-2-yl]-1-methyl-2-(methylthio)-1H-benz-imidazole-6-carboxamide
pH 7.0, 37°C
0.00037
6-((1-(benzylsulfonyl)piperidin-4-yl)amino)-3-(carboxymethoxy)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.042
6-bromo-3-carboxymethoxy-benzo(b)-thiophene-2-carboxylic acid
-
pH 7.0, 22°C
0.000044
6-hydroxy-2-phenyl-3-((3-trifluoromethyl)phenyl)benzofuran-5-carboxylic acid
-
at 25°C in 50 mM 3,3-dimethylglutarate buffer, pH 7.0
0.00023
acrolein
-
in sodium acetate (100 mM), bis-Tris (50 mM), Tris (50 mM), diethylenetriaminepentaacetic acid (5 mM), and 2,5-dimethylfuran (5% v/v), at pH 7 and 25°C
0.0363
benzyl (3R,6S)-4,9-dioxo-3-[(R)-phenyl(phenylamino)methyl]-1,5-diazonane-6-carboxylate
-
pH 7.5, 25°C
0.00014 - 0.0148
bis(2-ethyl-maltolato)oxidovanadium(IV)
0.0382
bis(3-hydroxy-2-methyl-4(1H)pyridinonato)oxidovanadium(IV)
pH 5.0, 22°C, recombinant enzyme, versus 4-nitrophenyl phosphate
0.00016 - 0.0065
bis(acetylacetonato)oxidovanadium(IV)
0.0108
ethyl 4-[4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenoxy]butanoate
-
pH not specified in the publication, temperature not specified in the publication
0.0152
ethyl [4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenoxy]acetate
-
pH not specified in the publication, temperature not specified in the publication
0.000017 - 0.00037
fluorescein arsenical hairpin binder
-
0.0118
lupenone
-
pH 6.0, 37°C
0.0034
lupeol
-
pH 6.0, 37°C
0.00134
methyl (6S,10S)-12-[(4-chloro-6-fluoro-2H-chromen-3-yl)methyl]-9-oxo-6,7,8,9,10,11-hexahydro-5H-6,10-epiminocycloocta[b]indole-8-carboxylate
-
inhibition of MptpB
0.0000024
N-((4-(difluoro(phosphono)methyl)phenyl)acetyl)-L-alpha-aspartyl-4-(difluoro(phosphono)methyl)-L-phenylalaninamide
-
-
0.0204
N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-nitrobenzene sulfonamide
-
-
0.0071
N-(6-methyl-1,3-benzothiazol-2-yl)-4-nitrobenzenesulfonamide
-
-
0.0034
N-[4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenyl]-4-tert-butylbenzamide
-
pH not specified in the publication, temperature not specified in the publication
0.0413
N-[6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazol-2-yl]-2,2,2-trifluoroacetamide
pH 7.0, 37°C
0.0003 - 0.0007
orthovanadate
0.00073 - 0.0107
phenylhydrazonopyrazolone sulfonate 1
0.017
PO43-
-
active site-directed inhibitor
0.002 - 0.0031
ursolic acid
0.0000056
Zn2+
at pH 7.4 and 25°C
0.1
[(1-benzyl-1H-indazol-5-yl)(difluoro)methyl]phosphonic acid
above, pH 6.2, 37°C
0.0844
[(2-benzyl-2H-indazol-5-yl)(difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.0923
[(4-bromophenyl)(difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.0033
[(4-[[3,5-bis(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.0014
[(4-[[4-bromo-3,5-bis(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.0049
[(4-[[4-bromo-3-(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.006
[(4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]phenyl)(difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.03
[4-[(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)prop-2-enoyl]phenoxy]acetic acid
-
pH not specified in the publication, temperature not specified in the publication
0.1
[biphenyl-4-yl(difluoro)methyl]phosphonic acid
above, pH 6.2, 37°C
0.0754
[difluoro(4-nitrophenyl)methyl]phosphonic acid
pH 6.2, 37°C
0.0548
[difluoro(4-[[2-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid
pH 6.2, 37°C
0.0107
[difluoro(4-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid
pH 6.2, 37°C
0.0185
[difluoro(4-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid
pH 6.2, 37°C
0.0114
[difluoro(4-[[4-fluoro-3-(trifluoromethyl)phenyl]carbamoyl]phenyl)methyl]phosphonic acid
pH 6.2, 37°C
0.1
[difluoro[3-(phenylcarbamoyl)phenyl]methyl]phosphonic acid
above, pH 6.2, 37°C
0.033
[difluoro[4-(1,3-thiazol-2-ylcarbamoyl)phenyl]methyl]phosphonic acid
pH 6.2, 37°C
0.1
[difluoro[4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]phosphonic acid
above, pH 6.2, 37°C
0.1
[difluoro[4-(methylcarbamoyl)phenyl]methyl]phosphonic acid
above, pH 6.2, 37°C
0.1
[difluoro[4-(phenoxymethyl)phenyl]methyl]phosphonic acid
above, pH 6.2, 37°C
0.024
[difluoro[4-(phenylcarbamoyl)phenyl]methyl]phosphonic acid
pH 6.2, 37°C
0.1
[difluoro[4-(phenylsulfamoyl)phenyl]methyl]phosphonic acid
above, pH 6.2, 37°C
0.1
[difluoro[4-(propan-2-ylcarbamoyl)phenyl]methyl]phosphonic acid
above, pH 6.2, 37°C
0.0655
[[4-(benzoylamino)phenyl](difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.0431
[[4-(benzylcarbamoyl)phenyl](difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.0031
[[4-([[3,5-bis(trifluoromethyl)phenyl]carbamoyl]amino)phenyl](difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.1
[[4-[(1-ethylpiperidin-4-yl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid
above, pH 6.2, 37°C
0.0446
[[4-[(2-bromophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.068
[[4-[(2-chlorophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.0182
[[4-[(3-bromophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.0349
[[4-[(3-chlorophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.0103
[[4-[(4-bromophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid
pH 6.2, 37°C
0.0168
[[4-[(4-chlorophenyl)carbamoyl]phenyl](difluoro)methyl]phosphonic acid
pH 6.2, 37°C
additional information
additional information
-
0.023
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant D48N, pH 7.0, 25°C
0.027
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, pH 7.0, 25°C
0.03
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C
0.1
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, pH 7.0, 25°C
0.1
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, mutant N47R/D48N, pH 7.0, 25°C
0.0003
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant D48N, pH 7.0, 25°C
0.00033
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C
0.00055
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, pH 7.0, 25°C
0.057
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C
0.113
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, pH 7.0, 25°C
0.019
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C
0.02
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant D48N, pH 7.0, 25°C
0.048
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, pH 7.0, 25°C
0.1
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, pH 7.0, 25°C
0.109
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C
0.00091
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant D48N, pH 7.0, 25°C
0.00094
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C
0.00128
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, pH 7.0, 25°C
0.08
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, pH 7.0, 25°C
0.115
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C
0.00061
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant D48N, pH 7.0, 25°C
0.00067
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C
0.00073
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, pH 7.0, 25°C
0.084
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C
0.147
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, pH 7.0, 25°C
0.00019
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant D48N, pH 7.0, 25°C
0.00031
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C
0.00061
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, pH 7.0, 25°C
0.00061
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, pH 7.0, 25°C
0.0038
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C
0.00017
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant D48N, H 7.0, 25°C
0.00019
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C
0.00049
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, pH 7.0, 25°C
0.064
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTP1B, pH 7.0, 25°C
0.088
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid
isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C
2
2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid
-
pH 5.5, 25°C, isozyme PTP1B
19
2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid
-
pH 5.5, 25°C, isozyme PTPalpha, mutant Q259G
33
2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid
-
pH 5.5, 25°C, isozyme PTP1B, mutant G259Q
81
2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]thiopyran-3-carboxylic acid
-
pH 5.5, 25°C, isozyme PTPalpha
0.2
3-(carboxymethoxy)thieno(2,3-b)pyridine-2-carboxylic acid
-
pH 5.5, 22°C
0.23
3-(carboxymethoxy)thieno(2,3-b)pyridine-2-carboxylic acid
-
pH 7.4, 22°C
0.00014
bis(2-ethyl-maltolato)oxidovanadium(IV)
pH 5.0, 22°C, recombinant enzyme, versus DADE(pY)LIPQQG
0.0148
bis(2-ethyl-maltolato)oxidovanadium(IV)
pH 5.0, 22°C, recombinant enzyme, versus 4-nitrophenyl phosphate
0.00016
bis(acetylacetonato)oxidovanadium(IV)
pH 5.0, 22°C, recombinant enzyme, versus DADE(pY)LIPQQG
0.0065
bis(acetylacetonato)oxidovanadium(IV)
pH 5.0, 22°C, recombinant enzyme, versus 4-nitrophenyl phosphate
0.000017
fluorescein arsenical hairpin binder
CCPGCC-insertion mutant TCPTP-187
-
0.000038
fluorescein arsenical hairpin binder
CCPGCC-insertion mutant PTPH1-816
-
0.000039
fluorescein arsenical hairpin binder
CCPGCC-insertion mutant PTPHalpha-406
-
0.000046
fluorescein arsenical hairpin binder
CCPGCC-insertion mutant PTP1B-186
-
0.000053
fluorescein arsenical hairpin binder
CCPGCC-insertion mutant PTP-PEST-204
-
0.000089
fluorescein arsenical hairpin binder
CCPGCC-insertion mutant HePTPH-211
-
0.00037
fluorescein arsenical hairpin binder
CCPGCC-insertion mutant FAP-1-2364
-
0.006
H2O2
-
PTP1B, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C
0.0074
H2O2
-
CD45, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C
0.0075
H2O2
-
HePTP, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C
0.0294
H2O2
-
VHR, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C
0.196
H2O2
-
PTPalpha, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C
0.00022
JTT-551
-
pH 7.5, 22°C, PTPB1
0.0093
JTT-551
-
pH 7.5, 22°C, TCPTP
0.03
JTT-551
-
above, pH 7.5, 22°C, CD45 and LAR
0.0003
orthovanadate
pH 5.0, 22°C, recombinant enzyme
0.0007
orthovanadate
-
Ki value for inhibition of wild type Shp2
0.00073
phenylhydrazonopyrazolone sulfonate 1
-
Ki value for inhibition of wild type Shp2
0.0058
phenylhydrazonopyrazolone sulfonate 1
-
Ki value for inhibition of mutant Shp2 R362K
0.0058
phenylhydrazonopyrazolone sulfonate 1
-
Ki value for inhibition of wild type PTP1B
0.0107
phenylhydrazonopyrazolone sulfonate 1
-
Ki value for inhibition of wild type Shp1
0.0053
suramin
-
Ki value for inhibition of wild type PTP1B
0.0057
suramin
-
Ki value for inhibition of wild type Shp2
0.002
ursolic acid
-
pH 6.0, 37°C
0.0031
ursolic acid
-
pH not specified in the publication, temperature not specified in the publication
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
inhibition kinetics of WPD loop insertion cysteine mutants with FlAsH, overview
-
additional information
additional information
-
PTPB1 inhibition kinetics, overview
-
additional information
additional information
-
Ru(III) complexes with thiolato groups, stopped-flow kinetic studies with both RuIII-EDTA and RuIII-hEDTRA with the thiol-containing biomolecules, GSH or Cys, in the buffer
-
additional information
additional information
inhibition kinetic analysis of (VO2+) chelates with PTP1B, Lineweaver-Burk plots, overview
-