Reference on EC 3.1.3.48 - protein-tyrosine-phosphatase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boivin, P.; Galand, C.
The human red cell acid phosphatase is a phosphotyrosine protein phosphatase which dephosphorylates the membrane protein band 3
Biochem. Biophys. Res. Commun.
134
557-564
1986
Homo sapiens
Roome, J.; O'Hare, T.; Pilch, P.F.; Brautigan, D.L.
Protein phosphotyrosine phosphatase purified from the particulate fraction of human placenta dephosphorylates insulin and growth-factor receptors
Biochem. J.
256
493-500
1988
Homo sapiens
Li, Y.; Strohl, W.R.
Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2)
J. Bacteriol.
178
136-142
1996
Streptomyces coelicolor
Tonks, N.K.; Diltz, C.D.; Fischer, E.H.
Characterization of the major protein-tyrosine-phosphatases of human placenta
J. Biol. Chem.
263
6731-6737
1988
Homo sapiens
Tonks, N.K.; Diltz, C.D.; Fischer, E.H.
Purification of the major protein-tyrosine-phosphatases of human placenta
J. Biol. Chem.
263
6722-6730
1988
Homo sapiens
Waheed, A.; Laidler, P.M.; Wo, Y.Y.P.; Van Etten, R.L.
Purification and physicochemical characterization of a human placental acid phosphatase possessing phosphotyrosyl protein phosphatase activity
Biochemistry
27
4265-4273
1988
Homo sapiens
Rotenberg, S.A.; Brautigan, D.L.
Membrane protein phosphotyrosine phosphatase in rabbit kidney. Proteolysis activates the enzyme and generates soluble catalytic fragments
Biochem. J.
243
747-754
1987
Oryctolagus cuniculus
Lim Tung, H.Y.; Reed, L.J.
Identification and purification of a cytosolic phosphotyrosyl protein phosphatase from bovine spleen
Anal. Biochem.
161
412-419
1987
Bos taurus
Tamura, S.; Suzuki, Y.; Kikuchi, K.; Tsuiki, S.
Identification and characterization of Mg2+-dependent phosphotyrosyl protein phosphatase from rat liver cytosol
Biochem. Biophys. Res. Commun.
140
212-218
1986
Rattus norvegicus
Okada, M.; Owada, K.; Nakagawa, H.
[Phosphotyrosine]protein phosphatase in rat brain. A major [phosphotyrosine]protein phosphatase is a 23 kDa protein distinct from acid phosphatase
Biochem. J.
239
155-162
1986
Rattus norvegicus
Clari, G.; Brunati, A.M.; Moret, V.
Partial purification and characterization of phosphotyrosyl-protein phosphatase(s) from human erythrocyte cytosol
Biochem. Biophys. Res. Commun.
137
566-572
1986
Homo sapiens
Brunati, A.M.; Pinna, L.A.
Isolation and partial characterization of distinct species of phosphotyrosyl protein phosphatases from rat spleen
Biochem. Biophys. Res. Commun.
133
929-936
1985
Rattus norvegicus
Lau, K.H.W.; Farley, J.R.; Baylink, D.J.
Phosphotyrosyl-specific protein phosphatase activity of a bovine skeletal acid phosphatase isoenzyme. Comparison with the phosphotyrosyl protein phosphatase activity of skeletal alkaline phosphatase
J. Biol. Chem.
260
4653-4660
1985
Bos taurus
Zhao, Z.; Laroque, R.; Ho, W.T.; Fischer, E.H.; Shen, S.H.
Purification and characterization of PTP2C, a widely distributed protein tyrosine phosphatase containing two SH2 domains
J. Biol. Chem.
269
8780-8785
1994
Homo sapiens
Chernoff, J.; Li, H.C.
Multiple forms of phosphotyrosyl- and phosphoseryl-protein phosphatase from cardiac muscle: partial purification and characterization of an EDTA-stimulated phosphotyrosyl-protein phosphatase
Arch. Biochem. Biophys.
226
517-530
1983
Bos taurus
Brautigan, D.L.; Bornstein, P.; Gallis, B.
Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn
J. Biol. Chem.
256
6519-6522
1981
Homo sapiens
Hrlein, D.; Gallis, B.; Brautigan, D.L.; Bornstein, P.
Partial purification and characterization of phosphotyrosyl-protein phosphatase from Ehrlich ascites tumor cells
Biochemistry
21
5577-5584
1982
Mus musculus
Fukami, Y.; Lipman, F.
Purification of a specific reversible tyrosine-O-phosphate phosphatase
Proc. Natl. Acad. Sci. USA
79
4275-4279
1982
Drosophila melanogaster
Gallis, B.; Bornstein, P.; Brautigan., D.L.
Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells
Proc. Natl. Acad. Sci. USA
78
6689-6693
1981
Rattus norvegicus
Foulkes, J.G.; Howard, R.F.; Ziemiecki, A.
Detection of a novel mammalian protein phosphatase with activity for phosphotyrosine
FEBS Lett.
130
197-200
1981
Rattus norvegicus
Aoyama, K.; Matsuda, T.; Aoki, N.
Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36
Biochem. Biophys. Res. Commun.
266
523-531
1999
Mus musculus (Q62130)
Ballou, L.M.; Fischer, E.H.
Phosphoprotein phosphatases
The Enzymes, 3rd Ed. (Boyer, P. D. ,ed.)
17
311-361
1986
Oryctolagus cuniculus
-
Foulkes, J.G.
Phosphotyrosyl-protein phosphatases
Curr. Top. Microbiol. Immunol.
107
163-180
1983
Gallus gallus, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Lau, K.H.W.; Farley, J.R.; Baylink, D.J.
Phosphotyrosyl protein phosphatases
Biochem. J.
257
23-36
1989
Gallus gallus, Homo sapiens, Mus musculus
Hernandez-Hernandez, A.; Sanchez-Yague, J.; Martin-Valmaseda, E.M.; Llaniloo, M.
Characterization of phosphotyrosine phosphatase activity in sheep platelets: amphiphilic and hydrophilic forms
Comp. Biochem. Physiol. B
117
437-444
1997
Ovis aries
Modesti, A.; Marzocchini, R.; Raugei, G.; Chiti, F.; Sereni, A.; Magherini, F.; Ramponi, G.
Cloning, expression and characterization of new human low Mr phosphotyrosine protein phosphatase originating by alternative splicing
FEBS Lett.
431
111-115
1998
Homo sapiens
Nishiwaki, T.; Maeda, N.; Noda, M.
Characterization and developmental regulation of proteoglycan-type protein-tyrosine phosphatase xi/RPTPbeta isoforms
J. Biochem.
123
458-467
1998
Rattus norvegicus
Buzalaf, M.A.R.; Taga, E.M.; Granjeiro, J.M.; Ferreira, C.V.; Lourencao, V.A.; Ortega, M.M.; Poletto, D.W.; Aoyama, H.
Kinetic characterization of bovine lung low-molecular-weight protein tyrosine phosphatase
Exp. Lung Res.
24
269-272
1998
Bos taurus
Grangeasse, C.; Doublet, P.; Vincent, C.; Vaganay, E.; Riberty, M.; Duclos, B.; Cozzone, A.J.
Functional characterization of the low-molecular-mass phosphotyrosine-protein phosphatase of Acinetobacter johnsonii
J. Mol. Biol.
278
339-347
1998
Acinetobacter johnsonii
Hundt, M.; Schmidt, R.E.
Functional characterization of receptor-type protein tyrosine phosphatase CD148 (HPTPeta/DEP-1) in Fcgamma receptor IIa signal transduction of human neutrophils
Eur. J. Immunol.
27
3532-3535
1997
Homo sapiens
Ohsugi, M.; Kuramochi, S.; Matsuda, S.; Yamamoto, T.
Molecular cloning and characterization of a novel cytoplasmic protein-tyrosine phosphatase that is specifically expressed in spermatocytes
J. Biol. Chem.
272
33092-33099
1997
Mus musculus
Shintani, T.; Maeda, N.; Nishiwaki, T.; Noda, M.
Characterization of rat receptor-like protein tyrosine phosphatase gamma isoforms
Biochem. Biophys. Res. Commun.
230
419-4235
1997
Rattus norvegicus
Gu, M.; Majerus, P.W.
The properties of the protein tyrosine phosphatase PTPMEG
J. Biol. Chem.
271
27751-27759
1996
Homo sapiens
Fauman, E.B.; Yuvaniyama, C.; Schubert, H.L.; Suckey, J.A.; Saper, m.A.
The x-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications
J. Biol. Chem.
271
18780-18788
1996
Yersinia enterocolitica (P15273)
Kim, C.W.; Jung, E.J.; Kang, Y.S.
Cloning and characterization of a chicken protein tyrosine phosphatase, CPTP1
Exp. Mol. Med.
28
207-213
1996
Gallus gallus
-
Dosil, M.; Leibman, N.; Lemischka, I.R.
Cloning and characterization of fetal liver phosphatase1, a nuclear protein tyrosine phosphatase isolated from hematopoietic stem cells
Blood
88
4510-4525
1996
Mus musculus
Cui, L.; Yu, W.P.; DeAizpurua, H.J.; Schmidli, R.S.; Pallen, C.J.
Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetis
J. Biol. Chem.
271
24817-24823
1996
Homo sapiens
Zhang, Z.Y.
Kinetic and mechanistic characterization of a mammalian protein-tyrosine phosphatase, PTP1
J. Biol. Chem.
270
11199-11204
1995
Rattus norvegicus
Zhang, Z.Y.; Clemens, J.C.; Schubert, H.L.; Stuckey, J.A.; Fischer, M.W.F.; Hume, D.M.; Saper, M.A.; Dixon, J.E.
Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase
J. Biol. Chem.
267
23759-23766
1992
Yersinia enterocolitica
Bakalara, N.; Seyfang, A.; Davis, C.; Baltz, T.
Characterization of a life-cycle-stage-regulated membrane protein tyrosine phosphatase in Trypanosoma brucei
Eur. J. Biochem.
234
871-877
1995
Trypanosoma brucei
Chida, D.; Kume, T.; Mukouyama, Y.; Tabata, S.; Nomura, N.; Thomas, M.L.; Watanabe, T.; Oishi, M.
Characterization of a protein tyrosine phosphatase (RIP) expressed in a very early stage of differentiation in both mouse erythroleukemia and embryonal carcinoma cells
FEBS Lett.
358
233-239
1995
Mus musculus
Sorio, C.; Mendrola, J.; Lou, Z.; LaForgia, S.; Croce, C.M.; Huebner, K.
Characterization of the receptor protein tyrosine phosphatase gene product PTPgamma: binding and activation by triphosphorylated nucleotides
Cancer Res.
55
4855-4864
1995
Homo sapiens
Dechert, U.; Adam, M.; Harder, K.W.; Clark-Lewis, I.; Jirik, F.
Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains
J. Biol. Chem.
269
5602-5611
1984
Homo sapiens (Q06124)
Hoppe, E.; Berne, P.F.; Stock, D.; Rasmussen, J.S.; Moller, N.P.H.
Expression, purification and crystallization of human phosphotyrosine phosphatase 1B
Eur. J. Biochem.
223
1069-1077
1994
Homo sapiens
Harder, K.W.; Owen, P.; Wong, L.K.H.; Aebersold, R.; Clark-Lewis, I.; Jirik, F.R.
Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTPbeta) using synthetic phosphopeptides
Biochem. J.
298
395-401
1994
Homo sapiens
-
Sugimoto, S.; Lechleider, R.J.; Shoelson, S.E.; Neel, B.G.; Walsh, C.T.
Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2
J. Biol. Chem.
268
227711-22776
1993
Homo sapiens
-
Mei, L.; Liao, K.; Huganir, R.L.
Characterization of substrate specificity of the protein tyrosine phosphatase purified from the electric organ of Torpedo californica
Neurosci. Lett.
182
21-24
1994
Tetronarce californica
Pei, D.; Neel, B.G.; Walsh, C.T.
Overexpression, purification, and characterization of SHPTPa, a src homology 2-containing protein-tyrosine-phosphatase
Proc. Natl. Acad. Sci. USA
90
1092-1096
1993
Homo sapiens
Cohen, S.; Dadi, H.; Shaoul, E.; Sharfe, N.; Riofam, C.M.
Cloning and characterization of a lymphoid-specific inducible human protein tyrosine phosphatase, Lyp
Blood
93
2013-2024
1999
Homo sapiens (Q9Y2R2), Homo sapiens
Pot, D.A.; Woodford, T.A.; Remboutsika, E.; Haun, R.S.; Dixon, J.E.
Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase
J. Biol. Chem.
266
19688-19696
1991
Rattus norvegicus (Q64604)
Daum, G.; Zander, N.F.; Morse, B.; Hurwitz, D.; Schlessinger, J.; Fischer, E.H.
Characterization of a human recombinant receptor-like protein tyrosine phosphatase
J. Biol. Chem.
266
12211-12215
1991
Homo sapiens
Ingebritsen, T.S.
Resolution and characterization of multiple protein-tyrosine phosphatase activities
Methods Enzymol.
201
201451-465
1991
Bos taurus
-
Singh, T.J.
Characterization of a bovine brain magnesium-dependent phosphotyrosine protein phosphatase that is inhibited by micromolar concentrations of calcium
Biochem. Biophys. Res. Commun.
167
621-627
1990
Bos taurus
Tonks, N.K.; Diltz, C.D.; Fischer, E.H.
CD45, an integral membrane protein tyrosine phosphatase. Characterization of enzyme activity
J. Biol. Chem.
256
10674-10680
1990
Homo sapiens
Wang, S.; Tabernero, L.; Zhang, M.; Harms, E.; van Etten, R.L.; Stauffacher, C.V.
Crystal structure of a low-molecular weight protein tyrosine phosphatase from Saccharomyces cerevisiae and its complex with the substrate p-nitrophenyl phosphate
Biochemistry
39
1903-1914
2000
Saccharomyces cerevisiae (P40347), Saccharomyces cerevisiae
Barford, D.; Flint, A.J.; Tonks, N.K.
Crystal structure of human protein tyrosine phosphatase 1B
Science
263
1397-1404
1994
Homo sapiens
Zhang, Z.Y.
Chemical and mechanistic approaches to the study of protein tyrosine phosphatases
Acc. Chem. Res.
36
385-392
2003
Yersinia enterocolitica
Thompson, L.J.; Jiang, J.; Madamanchi, N.; Runge, M.S.; Patterson, C.
PTP-epsilon, a tyrosine phosphatase expressed in endothelium, negatively regulates endothelial cell proliferation
Am. J. Physiol.
281
H396-H403
2001
Homo sapiens
Romsicki, Y.; Kennedy, B.P.; Asante-Appiah, E.
Purification and characterization of T cell protein tyrosine phosphatase reveals significant functional homology to protein tyrosine phosphatase-1B
Arch. Biochem. Biophys.
414
40-50
2003
Homo sapiens
Pedersen, A.K.; Guo, X.L.; Moller, K.B.; Peters, G.H.; Andersen, H.S.; Kastrup, J.S.; Mortensen, S.B.; Iversen, L.F.; Zhang, Z.Y.; Moller, N.P.H.
Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis
Biochem. J.
378
421-433
2004
Homo sapiens (P18031)
Chengalvala, M.V.; Bapat, A.R.; Hurlburt, W.W.; Kostek, B.; Gonder, D.S.; Mastroeni, R.A.; Frail, D.E.
Biochemical characterization of osteo-testicular protein tyrosine phosphatase and its functional significance in rat primary osteoblasts
Biochemistry
40
814-821
2001
Rattus norvegicus
Xie, L.; Zhang, Y.L.; Zhang, Z.Y.
Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant
Biochemistry
41
4032-4039
2002
Homo sapiens
Czyryca, P.G.; Hengge, A.C.
The mechanism of the phosphoryl transfer catalyzed by Yersinia protein-tyrosine phosphatase: a computational and isotope effect study
Biochim. Biophys. Acta
1547
245-253
2001
Yersinia enterocolitica
Peters, G.H.; Branner, S.; Moller, K.B.; Andersen, J.N.; Moller, N.P.H.
Enzyme kinetic characterization of protein tyrosine phosphatases
Biochimie
85
527-534
2003
Mammalia
Raugei, G.; Ramponi, G.; Chiarugi, P.
Low molecular weight protein tyrosine phosphatases: small, but smart
Cell. Mol. Life Sci.
59
941-949
2002
Homo sapiens, Mammalia
Zhang, Z.Y.
Protein tyrosine phosphatases: prospects for therapeutics
Curr. Opin. Chem. Biol.
5
416-423
2001
Homo sapiens
Kolmodin, K.; Aqvist, J.
The catalytic mechanism of protein tyrosine phosphatases revisited
FEBS Lett.
498
208-213
2001
Saccharomyces cerevisiae, Homo sapiens, Yersinia enterocolitica
Bixby, J.L.
Ligands and signaling through receptor-type tyrosine phosphatases
IUBMB Life
51
157-163
2001
Mammalia
Koul, A.; Choidas, A.; Treder, M.; Tyagi, A.K.; Drlica, K.; Singh, Y.; Ullrich, A.
Cloning and characterization of secretory tyrosine phosphatases of Mycobacterium tuberculosis
J. Bacteriol.
182
5425-5432
2000
Mycobacterium tuberculosis
Soulat, D.; Vaganay, E.; Duclos, B.; Genestier, A.L.; Etienne, J.; Cozzone, A.J.
Staphylococcus aureus contains two low-molecular-mass phosphotyrosine protein phosphatases
J. Bacteriol.
184
5194-5199
2002
Staphylococcus aureus
Tsuruta, H.; Aizono, Y.
Catalytic efficiency and some structural properties of cold-active protein-tyrosine-phosphatase
J. Biochem.
133
225-230
2003
Shewanella sp.
Peters, G.H.; Iversen, L.F.; Branner, S.; Andersen, H.S.; Mortensen, S.B.; Olsen, O.H.; Moller, K.B.; Moller, N.P.H.
Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha
J. Biol. Chem.
275
18201-18209
2000
Homo sapiens
Vetter, S.W.; Keng, Y.F.; Lawrence, D.S.; Zhang, Z.Y.
Assessment of protein-tyrosine phosphatase 1B substrate specificity using "inverse alanine scanning"
J. Biol. Chem.
275
2265-2268
2000
Homo sapiens
Yang, J.; Cheng, Z.; Niu, T.; Liang, X.; Zhao, Z.J.; Zhou, G.W.
Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1
J. Biol. Chem.
275
4066-4071
2000
Homo sapiens (P29350)
Chiarugi, P.; Cirri, P.; Taddei, L.; Giannoni, E.; Camici, G.; Manao, G.; Raugei, G.; Ramponi, G.
The low Mr protein-tyrosine phosphatase is involved in Rho-mediated cytoskeleton rearrangement after integrin and platelet-derived growth factor stimulation
J. Biol. Chem.
275
4640-4646
2000
Mus musculus
Calera, M.R.; Vallega, G.; Pilch, P.F.
Dynamics of protein-tyrosine phosphatases in rat adipocytes
J. Biol. Chem.
275
6308-6312
2000
Rattus norvegicus
Montagna, L.G.; Ivanov, M.I.; Bliska, J.B.
Identification of residues in the N-terminal domain of the Yersinia tyrosine phosphatase that are critical for substrate recognition
J. Biol. Chem.
276
5005-5011
2001
Yersinia enterocolitica
Romsicki, Y.; Scapin, G.; Beaulieu-Audy, V.; Patel, S.; Becker, J.W.; Kennedy, B.P.; Asante-Appiah, E.
Functional characterization and crystal structure of the C215D mutant of protein-tyrosine phosphatase-1B
J. Biol. Chem.
278
29009-29015
2003
Homo sapiens (P18031)
Yang, J.; Liu, L.; He, D.; Song, X.; Liang, X.; Zhao, Z.J.; Zhou, G.W.
Crystal structure of human protein-tyrosine phosphatase SHP-1
J. Biol. Chem.
278
6516-6520
2003
Homo sapiens
Qi, Y.; Zhao, R.; Cao, H.; Sui, X.; Krantz, S.B.; Zhao, Z.J.
Purification and characterization of protein tyrosine phosphatase PTP-MEG2
J. Cell. Biochem.
86
79-89
2002
Homo sapiens
Wabakken, T.; Hauge, H.; Funderud, S.; Aasheim, H.C.
Characterization, expression and functional aspects of a novel protein tyrosine phosphatase epsilon isoform
Scand. J. Immunol.
56
276-285
2002
Homo sapiens (Q8TE48), Homo sapiens
Welte, S.; Baringhaus, K.H.; Schmider, W.; Mueller, G.; Petry, S.; Tennagels, N.
6,8-Difluoro-4-methylumbiliferyl phosphate: a fluorogenic substrate for protein tyrosine phosphatases
Anal. Biochem.
338
32-38
2005
Homo sapiens, Yersinia sp.
Park, J.; Pei, D.
Trans-b-nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases
Biochemistry
43
15014-15021
2004
Homo sapiens
Peters, G.H.; Iversen, L.F.; Andersen, H.S.; Moller, N.P.; Olsen, O.H.
Residue 259 in protein-tyrosine phosphatase PTP1B and PTPalpha determines the flexibility of glutamine 262
Biochemistry
43
8418-8428
2004
Homo sapiens (P18031)
Lee, H.; Xie, L.; Luo, Y.; Lee, S.Y.; Lawrence, D.S.; Wang, X.B.; Sotgia, F.; Lisanti, M.P.; Zhang, Z.Y.
Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate
Biochemistry
45
234-240
2006
Homo sapiens
Seligman, J.; Zipser, Y.; Kosower, N.S.
Tyrosine phosphorylation, thiol status, and protein tyrosine phosphatase in rat epididymal spermatozoa
Biol. Reprod.
71
1009-1015
2004
Rattus norvegicus
Shim, Y.S.; Kim, K.C.; Lee, K.A.; Shrestha, S.; Lee, K.H.; Kim, C.K.; Cho, H.
Formylchromone derivatives as irreversible and selective inhibitors of human protein tyrosine phosphatase 1B. Kinetic and modeling studies
Bioorg. Med. Chem.
13
1325-1332
2005
Homo sapiens (P18031), Homo sapiens
Moretto, A.F.; Kirincich, S.J.; Xu, W.X.; Smith, M.J.; Wan, Z.K.; Wilson, D.P.; Follows, B.C.; Binnun, E.; Joseph-McCarthy, D.; Foreman, K.; Erbe, D.V.; Zhang, Y.L.; Tam, S.K.; Tam, S.Y.; Lee, J.
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors
Bioorg. Med. Chem.
14
2162-2177
2006
Homo sapiens
Puius, Y.A.; Zhao, Y.; Sullivan, M.; Lawrence, D.S.; Almo, S.C.; Zhang, Z.Y.
Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design
Proc. Natl. Acad. Sci. USA
94
13420-13425
1997
Homo sapiens (P18031), Homo sapiens
Na, M.; Oh, W.K.; Kim, Y.H.; Cai, X.F.; Kim, S.; Kim, B.Y.; Ahn, J.S.
Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum
Bioorg. Med. Chem. Lett.
16
3061-3064
2006
Homo sapiens
Tsuruta, H.; Tamura, J.; Yamagata, H.; Aizono, Y.
Specification of amino acid residues essential for the catalytic reaction of cold-active protein-tyrosine phosphatase of a psychrophile, Shewanella sp.
Biosci. Biotechnol. Biochem.
68
440-443
2004
Shewanella sp.
Cuevas, I.C.; Rohloff, P.; Sanchez, D.O.; Docampo, R.
Characterization of farnesylated protein tyrosine phosphatase TcPRL-1 from Trypanosoma cruzi
Eukaryot. Cell
4
1550-1561
2005
Trypanosoma cruzi (Q6JHV2), Trypanosoma cruzi
Fukaya, Y.; Yamaguchi, M.
Characterization of protein tyrosine phosphatase activity in rat liver microsomes: suppressive effect of endogenous regucalcin in transgenic rats
Int. J. Mol. Med.
14
427-432
2004
Rattus norvegicus
Madhurantakam, C.; Rajakumara, E.; Mazumdar, P.A.; Saha, B.; Mitra, D.; Wiker, H.G.; Sankaranarayanan, R.; Das, A.K.
Crystal structure of low-molecular-weight protein tyrosine phosphatase from Mycobacterium tuberculosis at 1.9-A resolution
J. Bacteriol.
187
2175-2181
2005
Mycobacterium tuberculosis (P9WIA1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIA1)
Mijakovic, I.; Musumeci, L.; Tautz, L.; Petranovic, D.; Edwards, R.A.; Jensen, P.R.; Mustelin, T.; Deutscher, J.; Bottini, N.
In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE
J. Bacteriol.
187
3384-3390
2005
Bacillus subtilis
Li, R.; Potters, M.B.; Shi, L.; Kennelly, P.J.
The protein phosphatases of Synechocystis sp. strain PCC 6803: open reading frames sll1033 and sll1387 encode enzymes that exhibit both protein-serine and protein-tyrosine phosphatase activity in vitro
J. Bacteriol.
187
5877-5884
2005
Synechocystis sp.
Xu, H.; Xia, B.; Jin, C.
Solution structure of a low-molecular-weight protein tyrosine phosphatase from Bacillus subtilis
J. Bacteriol.
188
1509-1517
2006
Bacillus subtilis (P39155), Bacillus subtilis
Tsuruta, H.; Mikami, B.; Aizono, Y.
Crystal structure of cold-active protein-tyrosine phosphatase from a psychrophile, Shewanella sp
J. Biochem.
137
69-77
2005
Shewanella sp.
McCain, D.F.; Wu, L.; Nickel, P.; Kassack, M.U.; Kreimeyer, A.; Gagliardi, A.; Collins, D.C.; Zhang, Z.Y.
Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases
J. Biol. Chem.
279
14713-14725
2004
Homo sapiens, Yersinia sp.
Lund, I.K.; Andersen, H.S.; Iversen, L.F.; Olsen, O.H.; Moller, K.B.; Pedersen, A.K.; Ge, Y.; Holsworth, D.D.; Newman, M.J.; Axe, F.U.; Moller, N.P.
Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase beta
J. Biol. Chem.
279
24226-24235
2004
Homo sapiens (P18031), Homo sapiens
Zabolotny, J.M.; Haj, F.G.; Kim, Y.B.; Kim, H.J.; Shulman, G.I.; Kim, J.K.; Neel, B.G.; Kahn, B.B.
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action
J. Biol. Chem.
279
24844-24851
2004
Homo sapiens
Lin, S.Y.; Raval, S.; Zhang, Z.; Deverill, M.; Siminovitch, K.A.; Branch, D.R.; Haimovich, B.
The protein-tyrosine phosphatase SHP-1 regulates the phosphorylation of alpha-actinin
J. Biol. Chem.
279
25755-25764
2004
Homo sapiens
Haj, F.G.; Zabolotny, J.M.; Kim, Y.B.; Kahn, B.B.; Neel, B.G.
Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice
J. Biol. Chem.
280
15038-15046
2005
Mus musculus
Liang, F.; Lee, S.Y.; Liang, J.; Lawrence, D.S.; Zhang, Z.Y.
The role of protein-tyrosine phosphatase 1B in integrin signaling
J. Biol. Chem.
280
24857-24863
2005
Homo sapiens
Xu, Y.; Tan, L.J.; Grachtchouk, V.; Voorhees, J.J.; Fisher, G.J.
Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function
J. Biol. Chem.
280
42694-42700
2005
Homo sapiens
Wu, J.; Katrekar, A.; Honigberg, L.A.; Smith, A.M.; Conn, M.T.; Tang, J.; Jeffery, D.; Mortara, K.; Sampang, J.; Williams, S.R.; Buggy, J.; Clark, J.M.
Identification of substrates of human protein-tyrosine phosphatase PTPN22
J. Biol. Chem.
281
11002-11010
2006
Homo sapiens
Montalibet, J.; Skorey, K.; McKay, D.; Scapin, G.; Asante-Appiah, E.; Kennedy, B.P.
Residues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding
J. Biol. Chem.
281
5258-5266
2006
Homo sapiens (P18031)
Asante-Appiah, E.; Patel, S.; Desponts, C.; Taylor, J.M.; Lau, C.; Dufresne, C.; Therien, M.; Friesen, R.; Becker, J.W.; Leblanc, Y.; Kennedy, B.P.; Scapin, G.
Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase
J. Biol. Chem.
281
8010-8015
2006
Homo sapiens
Nam, H.J.; Poy, F.; Saito, H.; Frederick, C.A.
Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45
J. Exp. Med.
201
441-452
2005
Homo sapiens
Maksumova, L.; Le, H.T.; Muratkhodjaev, F.; Davidson, D.; Veillette, A.; Pallen, C.J.
Protein tyrosine phosphatase alpha regulates Fyn activity and Cbp/PAG phosphorylation in thymocyte lipid rafts
J. Immunol.
175
7947-7956
2005
Mus musculus
Easton, J.B.; Royer, A.R.; Middlemas, D.S.
The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor
J. Neurochem.
97
834-845
2006
Rattus norvegicus
Zhou, Y.; Bhattacharjee, H.; Mukhopadhyay, R.
Bifunctional role of the leishmanial antimonate reductase LmACR2 as a protein tyrosine phosphatase
Mol. Biochem. Parasitol.
148
161-168
2006
Leishmania sp.
Rouleau, C.; Roy, A.; St Martin, T.; Dufault, M.R.; Boutin, P.; Liu, D.; Zhang, M.; Puorro-Radzwill, K.; Rulli, L.; Reczek, D.; Bagley, R.; Byrne, A.; Weber, W.; Roberts, B.; Klinger, K.; Brondyk, W.; Nacht, M.; Madden, S.; Burrier, R.; Shankara, S.; Teicher, B.A.
Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function
Mol. Cancer Ther.
5
219-229
2006
Homo sapiens
Granjeiro, J.M.; Miranda, M.A.; da Gloria, S.T.M.M.; Ferreira, C.V.; Taga, E.M.; Aoyama, H.; Volpe, P.L.
Effect of homologous series of n-alkyl sulfates and n-alkyl trimethylammonium bromides on low molecular mass protein tyrosine phosphatase activity
Mol. Cell. Biochem.
265
133-140
2004
Bos taurus
Wiesmann, C.; Barr, K.J.; Kung, J.; Zhu, J.; Erlanson, D.A.; Shen, W.; Fahr, B.J.; Zhong, M.; Taylor, L.; Randal, M.; McDowell, R.S.; Hansen, S.K.
Allosteric inhibition of protein tyrosine phosphatase 1B
Nat. Struct. Mol. Biol.
11
730-737
2004
Homo sapiens (P18031), Homo sapiens
Aguirre-Garcia, M.M.; Escalona-Montano, A.R.; Bakalara, N.; Perez-Torres, A.; Gutierrez-Kobeh, L.; Becker, I.
Leishmania major: detection of membrane-bound protein tyrosine phosphatase
Parasitology
132
641-649
2006
Leishmania major
Na, M.; Oh, W.K.; Kim, Y.H.; Cai, X.F.; Kim, S.; Kim, B.Y.; Ahn, J.S.
Na, M.; Yang, S.; He, L.; Oh, H.; Kim, B.S.; Oh, W.K.; Kim, B.Y.; Ahn, J.S.: Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata
Planta Med.
72
261-263
2006
Homo sapiens
Santos, M.A.; Santos, S.M.; Matozo, H.C.; Portugal, R.V.; Iuliano, R.; Fusco, A.; Polikarpov, I.
Expression, purification, and characterization of rat protein tyrosine phosphatase eta catalytic domain
Protein Expr. Purif.
41
113-120
2005
Rattus norvegicus
Gustafson, C.L.; Stauffacher, C.V.; Hallenga, K.; Van Etten, R.L.
Solution structure of the low-molecular-weight protein tyrosine phosphatase from Tritrichomonas foetus reveals a flexible phosphate binding loop
Protein Sci.
14
2515-2525
2005
Tritrichomonas suis
Eswaran, J.; Debreczeni, J.E.; Longman, E.; Barr, A.J.; Knapp, S.
The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1
Protein Sci.
15
1500-1505
2006
Homo sapiens
Grundner, C.; Ng, H.L.; Alber, T.
Mycobacterium tuberculosis protein tyrosine phosphatase PtpB structure reveals a diverged fold and a buried active site
Structure
13
1625-1634
2005
Mycobacterium tuberculosis (P96830), Mycobacterium tuberculosis
Evdokimov, A.G.; Pokross, M.; Walter, R.; Mekel, M.; Cox, B.; Li, C.; Bechard, R.; Genbauffe, F.; Andrews, R.; Diven, C.; Howard, B.; Rastogi, V.; Gray, J.; Maier, M.; Peters, K.G.
Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery
Acta Crystallogr. Sect. D
62
1435-1445
2006
Homo sapiens (P23467), Homo sapiens
Jeong, D.G.; Cho, Y.H.; Yoon, T.S.; Kim, J.H.; Son, J.H.; Ryu, S.E.; Kim, S.J.
Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family
Acta Crystallogr. Sect. D
62
582-588
2006
Homo sapiens
Felts, R.L.; Reilly, T.J.; Calcutt, M.J.; Tanner, J.J.
Crystallization of a newly discovered histidine acid phosphatase from Francisella tularensis
Acta Crystallogr. Sect. F
62
32-35
2006
Francisella tularensis
Matozo, H.C.; Nascimento, A.S.; Santos, M.A.; Iuliano, R.; Fusco, A.; Polikarpov, I.
Crystallization and preliminary X-ray diffraction analysis of rat protein tyrosine phosphatase eta
Acta Crystallogr. Sect. F
62
923-925
2006
Rattus norvegicus
Oliveira, D.M.; Machado, E.A.
Characterization of a tyrosine phosphatase activity in the oogenesis of Periplaneta americana
Arch. Insect Biochem. Physiol.
63
24-35
2006
Periplaneta americana
Eswaran, J.; von Kries, J.P.; Marsden, B.; Longman, E.; Debreczeni, J.E.; Ugochukwu, E.; Turnbull, A.; Lee, W.H.; Knapp, S.; Barr, A.J.
Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases
Biochem. J.
395
483-491
2006
Homo sapiens
Tiganis, T.; Bennett, A.M.
Protein tyrosine phosphatase function: the substrate perspective
Biochem. J.
402
1-15
2007
Mus musculus
Rudolph, J.
Cdc25 phosphatases: structure, specificity, and mechanism
Biochemistry
46
3595-3604
2007
Homo sapiens
Khajehpour, M.; Wu, L.; Liu, S.; Zhadin, N.; Zhang, Z.Y.; Callender, R.
Loop dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase
Biochemistry
46
4370-4378
2007
Yersinia pestis
Sohn, J.; Buhrman, G.; Rudolph, J.
Kinetic and structural studies of specific protein-protein interactions in substrate catalysis by Cdc25B phosphatase
Biochemistry
46
807-818
2007
Homo sapiens (P30305)
Forte, E.; Orsatti, L.; Talamo, F.; Barbato, G.; De Francesco, R.; Tomei, L.
Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3
Biochim. Biophys. Acta
1783
334-344
2008
Homo sapiens
Ferreira, C.V.; Justo, G.Z.; Souza, A.C.; Queiroz, K.C.; Zambuzzi, W.F.; Aoyama, H.; Peppelenbosch, M.P.
Natural compounds as a source of protein tyrosine phosphatase inhibitors: application to the rational design of small-molecule derivatives
Biochimie
88
1859-1873
2006
Homo sapiens, Homo sapiens (P30304), Homo sapiens (P30305), Homo sapiens (P30307)
Sohn, J.; Rudolph, J.
Temperature dependence of binding and catalysis for the Cdc25B phosphatase
Biophys. Chem.
125
549-555
2007
Homo sapiens
Li, Z.; Wang, Z.; Peng, G.; Yin, Y.; Zhao, H.; Cao, Y.; Xia, Y.
Purification and characterization of a novel thermostable extracellular protein tyrosine phosphatase from Metarhizium anisopliae strain CQMa102
Biosci. Biotechnol. Biochem.
70
1961-1968
2006
Metarhizium anisopliae, Metarhizium anisopliae CQMa102
Kochinyan, S.; Sun, L.; Ghosh, I.; Barshevsky, T.; Xu, J.; Xu, M.Q.
Use of intein-mediated phosphoprotein arrays to study substrate specificity of protein phosphatases
Biotechniques
42
63-69
2007
Homo sapiens
Besco, J.A.; Hooft van Huijsduijnen, R.; Frostholm, A.; Rotter, A.
Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT)
Brain Res.
1116
50-57
2006
Mus musculus, Mus musculus C57/BL6J
Iervolino, A.; Iuliano, R.; Trapasso, F.; Viglietto, G.; Melillo, R.M.; Carlomagno, F.; Santoro, M.; Fusco, A.
The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins
Cancer Res.
66
6280-6287
2006
Homo sapiens
Seiner, D.R.; LaButti, J.N.; Gates, K.S.
Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein
Chem. Res. Toxicol.
20
1315-1320
2007
Homo sapiens
Lavecchia, A.; Cosconati, S.; Limongelli, V.; Novellino, E.
Modeling of Cdc25B dual specificity protein phosphatase inhibitors: docking of ligands and enzymatic inhibition mechanism
ChemMedChem
1
540-550
2006
Homo sapiens (P30305), Homo sapiens
Nascimento, M.; Zhang, W.W.; Ghosh, A.; Houston, D.R.; Berghuis, A.M.; Olivier, M.; Matlashewski, G.
Identification and characterization of a protein-tyrosine phosphatase in Leishmania: Involvement in virulence
J. Biol. Chem.
281
36257-36268
2006
Homo sapiens, Leishmania donovani (Q0PEE2), Leishmania donovani 1S/Cl2D (Q0PEE2), Leishmania infantum, Leishmania major, Leishmania major Friedlin V9
Varmeh-Ziaie, S.; Manfredi, J.J.
The dual specificity phosphatase Cdc25B, but not the closely related Cdc25C, is capable of inhibiting cellular proliferation in a manner dependent upon its catalytic activity
J. Biol. Chem.
282
24633-24641
2007
Homo sapiens (P30305), Homo sapiens (P30307), Homo sapiens
Picha, K.M.; Patel, S.S.; Mandiyan, S.; Koehn, J.; Wennogle, L.P.
The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding
J. Biol. Chem.
282
2911-2917
2007
Homo sapiens
Kraut-Cohen, J.; Muller, W.J.; Elson, A.
Protein tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling
J. Biol. Chem.
283
4612-4621
2008
Mus musculus
Jeong, D.G.; Yoon, T.S.; Kim, J.H.; Shim, M.Y.; Jung, S.K.; Son, J.H.; Ryu, S.E.; Kim, S.J.
Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase
J. Mol. Biol.
360
946-955
2006
Homo sapiens (Q16828), Homo sapiens (Q99956), Homo sapiens (Q9Y6W6), Homo sapiens
Noordman, Y.E.; Jansen, P.A.; Hendriks, W.J.
Tyrosine-specific MAPK phosphatases and the control of ERK signaling in PC12 cells
J. Mol. Signal.
1
2006
2006
Mus musculus, Rattus norvegicus
Pendyala, P.R.; Ayong, L.; Eatrides, J.; Schreiber, M.; Pham, C.; Chakrabarti, R.; Fidock, D.A.; Allen, C.M.; Chakrabarti, D.
Characterization of a PRL protein tyrosine phosphatase from Plasmodium falciparum
Mol. Biochem. Parasitol.
158
1-10
2008
Plasmodium falciparum
Tiran, Z.; Peretz, A.; Sines, T.; Shinder, V.; Sap, J.; Attali, B.; Elson, A.
Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells
Mol. Biol. Cell
17
4330-4342
2006
Mus musculus
Madrid, M.; Nunez, A.; Soto, T.; Vicente-Soler, J.; Gacto, M.; Cansado, J.
Stress-activated protein kinase-mediated down-regulation of the cell integrity pathway mitogen-activated protein kinase Pmk1p by protein phosphatases
Mol. Biol. Cell
18
4405-4419
2007
Schizosaccharomyces pombe, Schizosaccharomyces pombe MI200
Lee, S.; Faux, C.; Nixon, J.; Alete, D.; Chilton, J.; Hawadle, M.; Stoker, A.W.
Dimerization of protein tyrosine phosphatase sigma governs both ligand binding and isoform specificity
Mol. Cell. Biol.
27
1795-1808
2007
Gallus gallus
Chen, Y.; Xu, Y.; Bao, Q.; Xing, Y.; Li, Z.; Lin, Z.; Stock, J.B.; Jeffrey, P.D.; Shi, Y.
Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40
Nat. Struct. Mol. Biol.
14
527-534
2007
Homo sapiens
Owens, D.M.; Keyse, S.M.
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
Oncogene
26
3203-3213
2007
Homo sapiens
Yu, X.; Sun, J.P.; He, Y.; Guo, X.; Liu, S.; Zhou, B.; Hudmon, A.; Zhang, Z.Y.
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases
Proc. Natl. Acad. Sci. USA
104
19767-19772
2007
Homo sapiens
Zhang, X.; Guo, A.; Yu, J.; Possemato, A.; Chen, Y.; Zheng, W.; Polakiewicz, R.D.; Kinzler, K.W.; Vogelstein, B.; Velculescu, V.E.; Wang, Z.J.
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T
Proc. Natl. Acad. Sci. USA
104
4060-4064
2007
Homo sapiens
Kim, S.J.; Jeong, D.G.; Yoon, T.S.; Son, J.H.; Cho, S.K.; Ryu, S.E.; Kim, J.H.
Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity
Proteins
66
239-245
2007
Homo sapiens
Chu, H.M.; Wang, A.H.
Enzyme-substrate interactions revealed by the crystal structures of the archaeal Sulfolobus PTP-fold phosphatase and its phosphopeptide complexes
Proteins
66
996-1003
2007
Saccharolobus solfataricus
Barr, A.J.; Knapp, S.
MAPK-specific tyrosine phosphatases: new targets for drug discovery?
Trends Pharmacol. Sci.
27
525-530
2006
Homo sapiens (P35236), Homo sapiens (P54829), Homo sapiens (Q15256), Homo sapiens
Korporaal, S.J.; Koekman, C.A.; Verhoef, S.; van der Wal, D.E.; Bezemer, M.; Van Eck, M.; Akkerman, J.W.
Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2
Arterioscler. Thromb. Vasc. Biol.
29
372-379
2009
Homo sapiens
Critton, D.A.; Tortajada, A.; Stetson, G.; Peti, W.; Page, R.
Structural basis of substrate recognition by hematopoietic tyrosine phosphatase
Biochemistry
47
13336-13345
2008
Homo sapiens (P35236)
Zhang, X.Y.; Chen, V.L.; Rosen, M.S.; Blair, E.R.; Lone, A.M.; Bishop, A.C.
Allele-specific inhibition of divergent protein tyrosine phosphatases with a single small molecule
Bioorg. Med. Chem.
16
8090-8097
2008
Homo sapiens (P18031)
Zhang, Y.N.; Zhang, W.; Hong, D.; Shi, L.; Shen, Q.; Li, J.Y.; Li, J.; Hu, L.H.
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities
Bioorg. Med. Chem.
16
8697-8705
2008
Homo sapiens (P29350)
Bhattacharya, S.; Labutti, J.N.; Seiner, D.R.; Gates, K.S.
Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides
Bioorg. Med. Chem. Lett.
18
5856-5859
2008
Homo sapiens
Wimmer-Kleikamp, S.H.; Nievergall, E.; Gegenbauer, K.; Adikari, S.; Mansour, M.; Yeadon, T.; Boyd, A.W.; Patani, N.R.; Lackmann, M.
Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells
Blood
112
721-732
2008
Homo sapiens
Hendriks, W.J.; Dilaver, G.; Noordman, Y.E.; Kremer, B.; Fransen, J.A.
PTPRR protein tyrosine phosphatase isoforms and locomotion of vesicles and mice
Cerebellum
8
80-88
2009
Mus musculus
Nakamura, Y.; Patrushev, N.; Inomata, H.; Mehta, D.; Urao, N.; Kim, H.W.; Razvi, M.; Kini, V.; Mahadev, K.; Goldstein, B.J.; McKinney, R.; Fukai, T.; Ushio-Fukai, M.
Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells
Circ. Res.
102
1182-1191
2008
Mus musculus
Swarbrick, M.M.; Havel, P.J.; Levin, A.A.; Bremer, A.A.; Stanhope, K.L.; Butler, M.; Booten, S.L.; Graham, J.L.; McKay, R.A.; Murray, S.F.; Watts, L.M.; Monia, B.P.; Bhanot, S.
Inhibition of protein tyrosine phosphatase-1B (PTP-1B) with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys
Endocrinology
150
1670-1679
2009
Macaca fascicularis, Macaca mulatta
Granot-Attas, S.; Elson, A.
Protein tyrosine phosphatases in osteoclast differentiation, adhesion, and bone resorption
Eur. J. Cell Biol.
87
479-490
2008
Mus musculus, Oryctolagus cuniculus
Braithwaite, S.P.; Xu, J.; Leung, J.; Urfer, R.; Nikolich, K.; Oksenberg, D.; Lombroso, P.J.; Shamloo, M.
Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia
Eur. J. Neurosci.
27
2444-2452
2008
Rattus norvegicus
Kiyan, J.; Haller, H.; Dumler, I.
The tyrosine phosphatase SHP-2 controls urokinase-dependent signaling and functions in human vascular smooth muscle cells
Exp. Cell Res.
315
1029-1039
2008
Homo sapiens
Dahche, H.; Abdullah, A.; Ben Potters, M.; Kennelly, P.J.
A PPM-family protein phosphatase from the thermoacidophile Thermoplasma volcanium hydrolyzes protein-bound phosphotyrosine
Extremophiles
13
371-377
2009
Thermoplasma volcanium
Tsuruta, H.; Mikami, B.; Yamamoto, C.; Yamagata, H.
The role of group bulkiness in the catalytic activity of psychrophile cold-active protein tyrosine phosphatase
FEBS J.
275
4317-4328
2008
Shewanella sp. (Q9S427)
Hendriks, W.J.; Elson, A.; Harroch, S.; Stoker, A.W.
Protein tyrosine phosphatases: functional inferences from mouse models and human diseases
FEBS J.
275
816-830
2008
Homo sapiens, Homo sapiens (O14522), Homo sapiens (P10586), Homo sapiens (P17706), Homo sapiens (P18031), Homo sapiens (P18433), Homo sapiens (P23467), Homo sapiens (P23468), Homo sapiens (P23469), Homo sapiens (P23470), Homo sapiens (P23471), Homo sapiens (P26045), Homo sapiens (P28827), Homo sapiens (P29074), Homo sapiens (P29350), Homo sapiens (P35236), Homo sapiens (P43378), Homo sapiens (P54829), Homo sapiens (Q05209), Homo sapiens (Q06124), Homo sapiens (Q0VAE8), Homo sapiens (Q12913), Homo sapiens (Q12923), Homo sapiens (Q13332), Homo sapiens (Q15256), Homo sapiens (Q15262), Homo sapiens (Q15678), Homo sapiens (Q16825), Homo sapiens (Q16827), Homo sapiens (Q16849), Homo sapiens (Q4JDK3), Homo sapiens (Q92729), Homo sapiens (Q92932), Homo sapiens (Q99952), Homo sapiens (Q9H3S7), Homo sapiens (Q9HD43), Homo sapiens (Q9UMZ3), Homo sapiens (Q9Y2R2)
Tabernero, L.; Aricescu, A.R.; Jones, E.Y.; Szedlacsek, S.E.
Protein tyrosine phosphatases: structure-function relationships
FEBS J.
275
867-882
2008
Homo sapiens, Yersinia sp.
Xu, D.; Qu, C.K.
Protein tyrosine phosphatases in the JAK/STAT pathway
Front. Biosci.
13
4925-4932
2008
Homo sapiens
Hirasaki, M.; Kaneko, Y.; Harashima, S.
Protein phosphatase Siw14 controls intracellular localization of Gln3 in cooperation with Npr1 kinase in Saccharomyces cerevisiae
Gene
409
34-43
2008
Saccharomyces cerevisiae
Kakazu, A.; Sharma, G.; Bazan, H.E.
Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing
Invest. Ophthalmol. Vis. Sci.
49
2927-2935
2008
Oryctolagus cuniculus, Homo sapiens
Liu, S.; Zhou, B.; Yang, H.; He, Y.; Jiang, Z.X.; Kumar, S.; Wu, L.; Zhang, Z.Y.
Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases
J. Am. Chem. Soc.
130
8251-8260
2008
Yersinia sp.
Carlucci, A.; Gedressi, C.; Lignitto, L.; Nezi, L.; Villa-Moruzzi, E.; Avvedimento, E.V.; Gottesman, M.; Garbi, C.; Feliciello, A.
Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration
J. Biol. Chem.
283
10919-10929
2008
Homo sapiens
Samayawardhena, L.A.; Pallen, C.J.
Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells
J. Biol. Chem.
283
29175-29185
2008
Mus musculus
Welters, H.J.; Oknianska, A.; Erdmann, K.S.; Ryffel, G.U.; Morgan, N.G.
The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway
J. Endocrinol.
197
543-552
2008
Homo sapiens
Suderman, R.J.; Pruijssers, A.J.; Strand, M.R.
Protein tyrosine phosphatase-H2 from a polydnavirus induces apoptosis of insect cells
J. Gen. Virol.
89
1411-1420
2008
Bracoviriform demolitoris
Lawrence, H.R.; Pireddu, R.; Chen, L.; Luo, Y.; Sung, S.S.; Szymanski, A.M.; Yip, M.L.; Guida, W.C.; Sebti, S.M.; Wu, J.; Lawrence, N.J.
Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds
J. Med. Chem.
51
4948-4956
2008
Homo sapiens
Thuong, P.T.; Lee, C.H.; Dao, T.T.; Nguyen, P.H.; Kim, W.G.; Lee, S.J.; Oh, W.K.
Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B
J. Nat. Prod.
71
1775-1778
2008
Homo sapiens
Chang, Y.C.; Lin, S.Y.; Liang, S.Y.; Pan, K.T.; Chou, C.C.; Chen, C.H.; Liao, C.L.; Khoo, K.H.; Meng, T.C.
Tyrosine phosphoproteomics and identification of substrates of protein tyrosine phosphatase dPTP61F in Drosophila S2 cells by mass spectrometry-based substrate trapping strategy
J. Proteome Res.
7
1055-1066
2008
Drosophila melanogaster
Allsup, D.; Harris, R.; Baker, P.; Cawley, J.
Protein-tyrosine phosphatase activity maintains the viability of hairy cells and modulates their response to interferon-alpha
Leuk. Lymphoma
49
2351-2358
2008
Homo sapiens
Kunnumakkara, A.B.; Nair, A.S.; Sung, B.; Pandey, M.K.; Aggarwal, B.B.
Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1
Mol. Cancer Res.
7
118-128
2009
Homo sapiens
Chabot, C.; Spring, K.; Gratton, J.P.; Elchebly, M.; Royal, I.
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival
Mol. Cell. Biol.
29
241-253
2009
Homo sapiens
McAlees, J.W.; Sanders, V.M.
Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes
Mol. Cell. Biol.
29
675-686
2009
Mus musculus
Young, J.A.; Becker, A.M.; Medeiros, J.J.; Shapiro, V.S.; Wang, A.; Farrar, J.D.; Quill, T.A.; Hooft van Huijsduijnen, R.; van Oers, N.S.
The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions
Mol. Immunol.
45
3756-3766
2008
Mus musculus
Ishino, Y.; Zhu, C.; Harris, D.L.; Joyce, N.C.
Protein tyrosine phosphatase-1B (PTP1B) helps regulate EGF-induced stimulation of S-phase entry in human corneal endothelial cells
Mol. Vis.
14
61-70
2008
Homo sapiens
Choi, J.Y.; Na, M.; Hyun Hwang, I.; Ho Lee, S.; Young Bae, E.; Yeon Kim, B.; Seog Ahn, J.
Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke
Molecules
14
266-272
2009
Homo sapiens
Gopishetty, B.; Ren, L.; Waller, T.M.; Wavreille, A.S.; Lopez, M.; Thakkar, A.; Zhu, J.; Pei, D.
Synthesis of 3,5-difluorotyrosine-containing peptides: application in substrate profiling of protein tyrosine phosphatases
Org. Lett.
10
4605-4608
2008
Homo sapiens
Kwon, J.H.; Chang, M.J.; Seo, H.W.; Lee, J.H.; Min, B.S.; Na, M.; Kim, J.C.; Woo, M.H.; Choi, J.S.; Lee, H.K.; Bae, K.
Triterpenoids and a sterol from the stem-bark of Styrax japonica and their protein tyrosine phosphatase 1B inhibitory activities
Phytother. Res.
22
1303-1306
2008
Homo sapiens
Ghelis, T.; Bolbach, G.; Clodic, G.; Habricot, Y.; Miginiac, E.; Sotta, B.; Jeannette, E.
Protein tyrosine kinases and protein tyrosine phosphatases are involved in abscisic acid-dependent processes in Arabidopsis seeds and suspension cells
Plant Physiol.
148
1668-1680
2008
Arabidopsis thaliana
Bauler, T.J.; Hendriks, W.J.; King, P.D.
The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction
PLoS ONE
3
e4014
2008
Mus musculus
Hellmuth, K.; Grosskopf, S.; Lum, C.T.; Wuertele, M.; Roeder, N.; von Kries, J.P.; Rosario, M.; Rademann, J.; Birchmeier, W.
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking
Proc. Natl. Acad. Sci. USA
105
7275-7280
2008
Homo sapiens
Boivin, B.; Zhang, S.; Arbiser, J.L.; Zhang, Z.Y.; Tonks, N.K.
A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells
Proc. Natl. Acad. Sci. USA
105
9959-9964
2008
Homo sapiens
Wang, Y.; Meng, F.; Zhang, Y.
Expression, purification and characterization of recombinant protein tyrosine phosphatase from Thermus thermophilus HB27
Acta Biochim. Biophys. Sin. (Shanghai)
41
689-698
2009
Thermus thermophilus (Q72JF6), Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 (Q72JF6)
Noeren-Mueller, A.; Wilk, W.; Saxena, K.; Schwalbe, H.; Kaiser, M.; Waldmann, H.
Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis
Angew. Chem.
47
5973-5977
2008
Mycobacterium tuberculosis
Zhang, X.Y.; Bishop, A.C.
Engineered inhibitor sensitivity in the WPD loop of a protein tyrosine phosphatase
Biochemistry
47
4491-4500
2008
Homo sapiens (P17706)
Bustanji, Y.; Taha, M.O.; Al-Masri, I.M.; Mohammad, M.K.
Docking simulations and in vitro assay unveil potent inhibitory action of papaverine against protein tyrosine phosphatase 1B
Biol. Pharm. Bull.
32
640-645
2009
Homo sapiens (P18031), Homo sapiens
Chiaradia, L.D.; Mascarello, A.; Purificacao, M.; Vernal, J.; Cordeiro, M.N.; Zenteno, M.E.; Villarino, A.; Nunes, R.J.; Yunes, R.A.; Terenzi, H.
Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA
Bioorg. Med. Chem. Lett.
18
6227-6230
2008
Mycobacterium tuberculosis
Seo, C.; Sohn, J.H.; Ahn, J.S.; Yim, J.H.; Lee, H.K.; Oh, H.
Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum
Bioorg. Med. Chem. Lett.
19
2801-2803
2009
Homo sapiens
Yoon, G.; Lee, W.; Kim, S.N.; Cheon, S.H.
Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B
Bioorg. Med. Chem. Lett.
19
5155-5157
2009
Homo sapiens
Seo, C.; Sohn, J.H.; Oh, H.; Kim, B.Y.; Ahn, J.S.
Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060
Bioorg. Med. Chem. Lett.
19
6095-6097
2009
Homo sapiens
Qiu, W.W.; Shen, Q.; Yang, F.; Wang, B.; Zou, H.; Li, J.Y.; Li, J.; Tang, J.
Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B
Bioorg. Med. Chem. Lett.
19
6618-6622
2009
Homo sapiens
Rawls, K.A.; Lang, P.T.; Takeuchi, J.; Imamura, S.; Baguley, T.D.; Grundner, C.; Alber, T.; Ellman, J.A.
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA
Bioorg. Med. Chem. Lett.
19
6851-6854
2009
Mycobacterium tuberculosis (P9WIA1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIA1)
Forghieri, M.; Laggner, C.; Paoli, P.; Langer, T.; Manao, G.; Camici, G.; Bondioli, L.; Prati, F.; Costantino, L.
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors
Bioorg. Med. Chem.
17
2658-2672
2009
Homo sapiens (P24666)
Navarrete-Vazquez, G.; Paoli, P.; Leon-Rivera, I.; Villalobos-Molina, R.; Medina-Franco, J.L.; Ortiz-Andrade, R.; Estrada-Soto, S.; Camici, G.; Diaz-Coutino, D.; Gallardo-Ortiz, I.; Martinez-Mayorga, K.; Moreno-Diaz, H.
Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity
Bioorg. Med. Chem.
17
3332-3341
2009
Rattus norvegicus
Mattila, E.; Marttila, H.; Sahlberg, N.; Kohonen, P.; Taehtinen, S.; Halonen, P.; Peraelae, M.; Ivaska, J.
Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase
BMC Cancer
10
7
2010
Mus musculus
Ahn, K.S.; Sethi, G.; Sung, B.; Goel, A.; Ralhan, R.; Aggarwal, B.B.
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1
Cancer Res.
68
4406-4415
2008
Homo sapiens
Chatterjee, D.; Mitra, A.; Levina, A.; Lay, P.A.
A potential role for protein tyrosine phosphatase inhibition by a RuIII-edta complex (edta = ethylenediaminetetraacetate) in its biological activity
Chem. Commun. (Camb. )
2008
2864-2866
2008
Yersinia enterocolitica
Maccari, R.; Ottana, R.; Ciurleo, R.; Paoli, P.; Manao, G.; Camici, G.; Laggner, C.; Langer, T.
Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase
ChemMedChem
4
957-962
2009
Homo sapiens (P18031)
Araki, T.; Langenick, J.; Gamper, M.; Firtel, R.A.; Williams, J.G.
Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase
Development
135
1347-1353
2008
Dictyostelium discoideum
Fukuda, S.; Ohta, T.; Sakata, S.; Morinaga, H.; Ito, M.; Nakagawa, Y.; Tanaka, M.; Matsushita, M.
Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551
Diabetes Obes. Metab.
12
299-306
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Jung, S.K.; Jeong, D.G.; Chung, S.J.; Kim, J.H.; Park, B.C.; Tonks, N.K.; Ryu, S.E.; Kim, S.J.
Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor
FASEB J.
24
560-569
2010
Homo sapiens (O00167), Homo sapiens
Abdo, M.; Liu, S.; Zhou, B.; Walls, C.D.; Wu, L.; Knapp, S.; Zhang, Z.Y.
Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases
J. Am. Chem. Soc.
130
13196-13197
2008
Yersinia sp.
Brandao, T.A.; Hengge, A.C.; Johnson, S.J.
Insights into the reaction of protein tyrosine phosphatase 1B. Crystal structures for transition-state analogs of both catalytic steps
J. Biol. Chem.
285
15874-15883
2010
Homo sapiens (P18031)
Yuan, C.; Lu, L.; Gao, X.; Wu, Y.; Guo, M.; Li, Y.; Fu, X.; Zhu, M.
Ternary oxovanadium(IV) complexes of ONO-donor Schiff base and polypyridyl derivatives as protein tyrosine phosphatase inhibitors: synthesis, characterization, and biological activities
J. Biol. Inorg. Chem.
14
841-851
2009
Homo sapiens
Fang, L.; Zhang, H.; Cui, W.; Ji, M.
Studies of the mechanism of selectivity of protein tyrosine phosphatase 1B (PTP1B) bidentate inhibitors using molecular dynamics simulations and free energy calculations
J. Chem. Inf. Model.
48
2030-2041
2008
Homo sapiens
Na, M.; Kim, B.Y.; Osada, H.; Ahn, J.S.
Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta
J. Enzyme Inhib. Med. Chem.
24
1056-1059
2009
Homo sapiens
Patrignani, C.; Lafont, D.T.; Muzio, V.; Greco, B.; Hooft van Huijsduijnen, R.; Zaratin, P.F.
Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation
J. Inflamm.
7
16
2010
Mus musculus
Zhou, D.; Collins, C.A.; Wu, P.; Brown, E.J.
Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase
J. Leukoc. Biol.
87
845-855
2010
Mus musculus
Krishnamurthy, D.; Karver, M.R.; Fiorillo, E.; Orru, V.; Stanford, S.M.; Bottini, N.; Barrios, A.M.
Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study
J. Med. Chem.
51
4790-4795
2008
Homo sapiens, Yersinia enterolytica
Price, K.A.; Caragounis, A.; Paterson, B.M.; Filiz, G.; Volitakis, I.; Masters, C.L.; Barnham, K.J.; Donnelly, P.S.; Crouch, P.J.; White, A.R.
Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity
J. Med. Chem.
52
6606-6620
2009
Homo sapiens
Nakashima, S.; Arnold, S.A.; Mahoney, E.T.; Sithu, S.D.; Zhang, Y.P.; D'Souza, S.E.; Shields, C.B.; Hagg, T.
Small-molecule protein tyrosine phosphatase inhibition as a neuroprotective treatment after spinal cord injury in adult rats
J. Neurosci.
28
7293-7303
2008
Rattus norvegicus
Kapoor, S.; Girish, T.S.; Mandal, S.S.; Gopal, B.; Bhattacharyya, A.J.
Inhibition of a protein tyrosine phosphatase using mesoporous oxides
J. Phys. Chem. B
114
3117-3121
2010
Gallus gallus
Xue, B.; Pulinilkunnil, T.; Murano, I.; Bence, K.K.; He, H.; Minokoshi, Y.; Asakura, K.; Lee, A.; Haj, F.; Furukawa, N.; Catalano, K.J.; Delibegovic, M.; Balschi, J.A.; Cinti, S.; Neel, B.G.; Kahn, B.B.
Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues
Mol. Cell. Biol.
29
4563-4573
2009
Mus musculus
Xi, G.; Shen, X.; Clemmons, D.R.
p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 membrane
Mol. Endocrinol.
22
2162-2175
2008
Homo sapiens
Bae, D.; Camilli, T.C.; Chun, G.; Lal, M.; Wright, K.; OBrien, T.J.; Patierno, S.R.; Ceryak, S.
Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis
Mutat. Res.
660
40-46
2009
Homo sapiens
Rodriguez-Ubreva, F.J.; Cariaga-Martinez, A.E.; Cortes, M.A.; Romero-De Pablos, M.; Ropero, S.; Lopez-Ruiz, P.; Colas, B.
Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery
Oncogene
29
345-355
2010
Homo sapiens
Tan, L.P.; Wu, H.; Yang, P.Y.; Kalesh, K.A.; Zhang, X.; Hu, M.; Srinivasan, R.; Yao, S.Q.
High-throughput discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitors using click chemistry
Org. Lett.
11
5102-5105
2009
Mycobacterium tuberculosis
Dao, T.T.; Nguyen, P.H.; Thuong, P.T.; Kang, K.W.; Na, M.; Ndinteh, D.T.; Mbafor, J.T.; Oh, W.K.
Pterocarpans with inhibitory effects on protein tyrosine phosphatase 1B from Erythrina lysistemon Hutch
Phytochemistry
70
2053-2057
2009
Homo sapiens
Wang, V.; Davis, D.A.; Veeranna, R.P.; Haque, M.; Yarchoan, R.
Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha
PLoS ONE
5
e9641
2010
Homo sapiens
Zhao, Y.; Zhang, X.; Guda, K.; Lawrence, E.; Sun, Q.; Watanabe, T.; Iwakura, Y.; Asano, M.; Wei, L.; Yang, Z.; Zheng, W.; Dawson, D.; Willis, J.; Markowitz, S.D.; Satake, M.; Wang, Z.
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T
Proc. Natl. Acad. Sci. USA
107
2592-2597
2010
Homo sapiens
Shi, M.; Chen, Y.F.; Yao, Y.; Huang, F.; Chen, X.X.
Characterization of a protein tyrosine phosphatase gene CvBV202 from Cotesia vestalis polydnavirus (CvBV)
Virus Genes
36
595-601
2008
Cotesia vestalis bracovirus
Gallo, G.; Ramos, T.C.; Tavares, F.; Rocha, A.A.; Machi, E.; Schenkman, S.; Bahia, D.; Pesquero, J.B.; Wuertele, M.
Biochemical characterization of a protein tyrosine phosphatase from Trypanosoma cruzi involved in metacyclogenesis and cell invasion
Biochem. Biophys. Res. Commun.
408
427-431
2011
Trypanosoma cruzi, Trypanosoma cruzi Brener
Ren, L.; Chen, X.; Luechapanichkul, R.; Selner, N.G.; Meyer, T.M.; Wavreille, A.S.; Chan, R.; Iorio, C.; Zhou, X.; Neel, B.G.; Pei, D.
Substrate specificity of protein tyrosine phosphatases 1B, RPTPalpha, SHP-1, and SHP-2
Biochemistry
50
2339-2356
2011
Homo sapiens
Chia, J.Y.; Gajewski, J.E.; Xiao, Y.; Zhu, H.J.; Cheng, H.C.
Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN
Biochim. Biophys. Acta
1804
1785-1795
2010
Homo sapiens
Liu, Z.; Lee, W.; Kim, S.N.; Yoon, G.; Cheon, S.H.
Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors
Bioorg. Med. Chem. Lett.
21
3755-3758
2011
Homo sapiens
Chandra, K.; Dutta, D.; Das, A.K.; Basak, A.
Design, synthesis and inhibition activity of novel cyclic peptides against protein tyrosine phosphatase A from Mycobacterium tuberculosis
Bioorg. Med. Chem.
18
8365-8373
2010
Mycobacterium tuberculosis
Chen, V.L.; Bishop, A.C.
Chemical rescue of protein tyrosine phosphatase activity
Chem. Commun. (Camb. )
46
637-639
2010
Homo sapiens
Eum, J.H.; Bottjen, R.C.; Pruijssers, A.J.; Clark, K.D.; Strand, M.R.
Characterization and kinetic analysis of protein tyrosine phosphatase-H2 from Microplitis demolitor bracovirus
Insect Biochem. Mol. Biol.
40
690-698
2010
Bracoviriform demolitoris
Mukhopadhyay, A.; Kennelly, P.J.
A low molecular weight protein tyrosine phosphatase from c: enzymatic characterization and identification of its potential substrates
J. Biochem.
149
551-562
2011
Synechocystis sp.
Yu, X.; Chen, M.; Zhang, S.; Yu, Z.H.; Sun, J.P.; Wang, L.; Liu, S.; Imasaki, T.; Takagi, Y.; Zhang, Z.Y.
Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate
J. Biol. Chem.
286
30526-30534
2011
Homo sapiens
Ferrari, E.; Tinti, M.; Costa, S.; Corallino, S.; Nardozza, A.P.; Chatraryamontri, A.; Ceol, A.; Cesareni, G.; Castagnoli, L.
Identification of new substrates of the protein-tyrosine phosphatase PTP1B by Bayesian integration of proteome evidence
J. Biol. Chem.
286
4173-4185
2011
Homo sapiens
Wang, W.; Liu, L.; Song, X.; Mo, Y.; Komma, C.; Bellamy, H.D.; Zhao, Z.J.; Zhou, G.W.
Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation
J. Cell. Biochem.
112
2062-2071
2011
Homo sapiens
Iype, T.; Sankarshanan, M.; Mauldin, I.S.; Mullins, D.W.; Lorenz, U.
The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells
J. Immunol.
185
6115-6127
2010
Mus musculus, Mus musculus BALB/c
Vega, C.; Chou, S.; Engel, K.; Harrell, M.E.; Rajagopal, L.; Grundner, C.
Structure and substrate recognition of the Staphylococcus aureus protein tyrosine phosphatase PtpA
J. Mol. Biol.
413
24-31
2011
Staphylococcus aureus
Reimann, J.; Esser, D.; Orell, A.; Amman, F.; Pham, T.K.; Noirel, J.; Lindas A.C.; Bernander, R.; Wright, P.C.; Siebers, B.; Albers, S.V.
Archaeal signal transduction: impact of protein phosphatase deletions on cell size, motility, and energy metabolism in Sulfolobus acidocaldarius
Mol. Cell. Proteomics
12
3908-3923
2013
Sulfolobus acidocaldarius (Q4JB88), Sulfolobus acidocaldarius, Sulfolobus acidocaldarius MW001 (Q4JB88)
Harris, L.K.; Frumm, S.M.; Bishop, A.C.
A general assay for monitoring the activities of protein tyrosine phosphatases in living eukaryotic cells
Anal. Biochem.
435
99-105
2013
Homo sapiens, Mus musculus
Heneberg, P.
Reactive nitrogen species and hydrogen sulfide as regulators of protein tyrosine phosphatase activity
Antioxid. Redox Signal.
20
2191-2209
2014
Mycobacterium tuberculosis
Song, D.D.; Chen, Y.; Li, Z.Y.; Guan, Y.F.; Zou, D.J.; Miao, C.Y.
Protein tyrosine phosphatase 1B inhibits adipocyte differentiation and mediates TNFalpha action in obesity
Biochim. Biophys. Acta
1831
1368-1376
2013
Mus musculus
Mitra, A.; Sasikumar, K.; Parthasaradhi, B.V.; Radha, V.
The tyrosine phosphatase TC48 interacts with and inactivates the oncogenic fusion protein BCR-Abl but not cellular Abl
Biochim. Biophys. Acta
1832
275-284
2013
Homo sapiens (P17706), Homo sapiens
Meng, F.G.; Zhang, Z.Y.
Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical
Biochim. Biophys. Acta
1834
464-469
2013
Homo sapiens
He, H.B.; Gao, L.X.; Deng, Q.F.; Ma, W.P.; Tang, C.L.; Qiu, W.W.; Tang, J.; Li, J.Y.; Li, J.; Yang, F.
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B
Bioorg. Med. Chem. Lett.
22
7237-7242
2012
Homo sapiens
Hu, X.; Vujanac, M.; Southall, N.; Stebbins, C.E.
Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches
Bioorg. Med. Chem. Lett.
23
1056-1062
2013
Yersinia pestis
Wang, Z.; Liu, Z.; Lee, W.; Kim, S.N.; Yoon, G.; Cheon, S.H.
Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B
Bioorg. Med. Chem. Lett.
24
3337-3340
2014
Homo sapiens (P18031)
Zhi, Y.; Gao, L.X.; Jin, Y.; Tang, C.L.; Li, J.Y.; Li, J.; Long, Y.Q.
4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B
Bioorg. Med. Chem.
22
3670-3683
2014
Homo sapiens
Motohashi, S.; Koizumi, K.; Honda, R.; Maruyama, A.; Palmer, H.E.; Mashima, K.
Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners
Cell. Immunol.
289
128-134
2014
Rattus norvegicus
Xu, J.; Kurup, P.; Bartos, J.A.; Patriarchi, T.; Hell, J.W.; Lombroso, P.J.
Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity
J. Biol. Chem.
287
20942-20956
2012
Mus musculus
Stehle, T.; Sreeramulu, S.; Loehr, F.; Richter, C.; Saxena, K.; Jonker, H.R.; Schwalbe, H.
The apo-structure of the low molecular weight protein-tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development
J. Biol. Chem.
287
34569-34582
2012
Mycobacterium tuberculosis (P9WIA1), Mycobacterium tuberculosis
He, Y.; Xu, J.; Yu, Z.H.; Gunawan, A.M.; Wu, L.; Wang, L.; Zhang, Z.Y.
Discovery and evaluation of novel inhibitors of Mycobacterium protein tyrosine phosphatase B from the 6-hydroxy-benzofuran-5-carboxylic acid scaffold
J. Med. Chem.
56
832-842
2013
Mycobacterium tuberculosis
Bellomo, E.; Massarotti, A.; Hogstrand, C.; Maret, W.
Zinc ions modulate protein tyrosine phosphatase 1B activity
Metallomics
6
1229-1239
2014
Homo sapiens (P18031), Homo sapiens
Sun, G.; Cheng, S.Y.; Chen, M.; Lim, C.J.; Pallen, C.J.
Protein tyrosine phosphatase alpha phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions
Mol. Cell. Biol.
32
3776-3789
2012
Mus musculus
Yin, J.P.; Tang, C.L.; Gao, L.X.; Ma, W.P.; Li, J.Y.; Li, Y.; Li, J.; Nan, F.J.
Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors
Org. Biomol. Chem.
12
3441-3445
2014
Homo sapiens
Uddin, M.N.; Sharma, G.; Yang, J.L.; Choi, H.S.; Lim, S.I.; Kang, K.W.; Oh, W.K.
Oleanane triterpenes as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Camellia japonica
Phytochemistry
103
99-106
2014
Homo sapiens
Li, B.; Zhao, Y.; Liang, L.; Ren, H.; Xing, Y.; Chen, L.; Sun, M.; Wang, Y.; Han, Y.; Jia, H.; Huang, C.; Wu, Z.; Jia, W.
Purification and characterization of ZmRIP1, a novel reductant-inhibited protein tyrosine phosphatase from maize
Plant Physiol.
159
671-681
2012
Zea mays (B4FJN0), Zea mays
Gruninger, R.J.; Thibault, J.; Capeness, M.J.; Till, R.; Mosimann, S.C.; Sockett, R.E.; Selinger, B.L.; Lovering, A.L.
Structural and biochemical analysis of a unique phosphatase from Bdellovibrio bacteriovorus reveals its structural and functional relationship with the protein tyrosine phosphatase class of phytase
PLoS ONE
9
e94403
2014
Bdellovibrio bacteriovorus (Q6MNP0), Bdellovibrio bacteriovorus, Bdellovibrio bacteriovorus HD100 (Q6MNP0)
Li, S.; Zhang, J.; Lu, S.; Huang, W.; Geng, L.; Shen, Q.; Zhang, J.
The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B
PLoS ONE
9
e97668
2014
Homo sapiens (P18031)
Bakke, J.; Haj, F.G.
Protein-tyrosine phosphatase 1B substrates and metabolic regulation
Semin. Cell Dev. Biol.
37
58-65
2015
Homo sapiens
Tanase, C.A.
Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL
PLoS ONE
5
e14339
2010
Homo sapiens
Lountos, G.; Kurussi, S.; Zhao, B.; Dyas, B.; Burke, T.J.; Ulrich, R.; Waugh, D.
High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design
Acta Crystallogr. Sect. D
74
1015-1026
2018
Homo sapiens (P23469), Homo sapiens
Ku, B.; Keum, C.W.; Lee, H.S.; Yun, H.Y.; Shin, H.C.; Kim, B.Y.; Kim, S.J.
Crystal structure of SP-PTP, a low molecular weight protein tyrosine phosphatase from Streptococcus pyogenes
Biochem. Biophys. Res. Commun.
478
1217-1222
2016
Streptococcus pyogenes serotype M1 (Q9A1Y0)
Bishop, A.C.
A missense methionine mutation augments catalytic activity but reduces thermal stability in two protein tyrosine phosphatases
Biochem. Biophys. Res. Commun.
481
153-158
2016
Homo sapiens (P29350), Homo sapiens
Srinivasan, B.; Marks, H.; Mitra, S.; Smalley, D.M.; Skolnick, J.
Catalytic and substrate promiscuity distinct multiple chemistries catalysed by the phosphatase domain of receptor protein tyrosine phosphatase
Biochem. J.
473
2165-2177
2016
Homo sapiens (P23468), Homo sapiens (Q15256)
Tabernero, L.; Woodman, P.
Dissecting the role of His domain protein tyrosine phosphatase/PTPN23 and ESCRTs in sorting activated epidermal growth factor receptor to the multivesicular body
Biochem. Soc. Trans.
46
1037-1046
2018
Saccharomyces cerevisiae, Homo sapiens (Q9H3S7)
Hjortness, M.; Riccardi, L.; Hongdusit, A.; Ruppe, A.; Zhao, M.; Kim, E.; Zwart, P.; Sankaran, B.; Arthanari, H.; Sousa, M.; De Vivo, M.; Fox, J.
Abietane-type diterpenoids inhibit protein tyrosine phosphatases by stabilizing an inactive enzyme conformation
Biochemistry
57
5886-5896
2018
Homo sapiens (P18031)
-
Hengge, A.C.
Kinetic isotope effects in the characterization of catalysis by protein tyrosine phosphatases
Biochim. Biophys. Acta
1854
1768-1775
2015
Yersinia sp., Homo sapiens (P18031), Homo sapiens (P51452), Homo sapiens (Q9BVJ7), Mus musculus (P35821), Schizosaccharomyces pombe (P41893), Schizosaccharomyces pombe ATCC 24843 (P41893)
Segerer, G.; Engelmann, D.; Kaestner, A.; Troetzmueller, M.; Koefeler, H.; Stigloher, C.; Thiele, C.; Jeanclos, E.; Gohla, A.
A phosphoglycolate phosphatase/AUM-dependent link between triacylglycerol turnover and epidermal growth factor signaling
Biochim. Biophys. Acta
1863
584-594
2018
Mus musculus (Q8CHP8)
Zhang, L.; Ge, Y.; Song, H.M.; Wang, Q.M.; Zhou, C.H.
Design, synthesis of novel azolyl flavonoids and their protein tyrosine Phosphatase-1B inhibitory activities
Bioorg. Chem.
80
195-203
2018
Homo sapiens (P18031)
Peti, W.; Page, R.
Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable Achieving specificity by targeting substrate and regulatory protein interaction sites
Bioorg. Med. Chem.
23
2781-2785
2015
Homo sapiens (P18031)
Korntner, S.; Pomorski, A.; Krezel, A.; Bishop, A.C.
Optimized allosteric inhibition of engineered protein tyrosine phosphatases with an expanded palette of biarsenical small molecules
Bioorg. Med. Chem.
26
2610-2620
2018
Homo sapiens (P18031)
Ge, L.; Li, K.S.; Li, M.M.; Xiao, P.; Hou, X.B.; Chen, X.; Liu, H.D.; Lin, A.; Yu, X.; Ren, G.J.; Fang, H.; Sun, J.P.
Identification of a benzo imidazole thiazole derivative as the specific irreversible inhibitor of protein tyrosine phosphatase
Bioorg. Med. Chem. Lett.
26
4795-4798
2016
Homo sapiens (P54829), Homo sapiens
Zhang, X.; Yang, S.; Li, X.; Zhu, P.; Xie, E.; Li, Z.
Expression, purification, and characterization of a novel acid phosphatase that displays protein tyrosine phosphatases activity from Metarhizium anisopliae strain CQMa102
Biosci. Biotechnol. Biochem.
81
2292-2300
2017
Metarhizium anisopliae (A1X864), Metarhizium anisopliae, Metarhizium anisopliae CQMa102 (A1X864)
Guerra, L.L.; Faccinetti, N.I.; Trabucchi, A.; Rovitto, B.D.; Sabljic, A.V.; Poskus, E.; Iacono, R.F.; Valdez, S.N.
Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application
BMC Biotechnol.
16
84
2016
Homo sapiens (Q16849)
Abdjul, D.B.; Yamazaki, H.; Kanno, S.I.; Kirikoshi, R.; Tomizawa, A.; Takahashi, O.; Maarisit, W.; Losung, F.; Rotinsulu, H.; Wewengkang, D.S.; Sumilat, D.A.; Kapojos, M.M.; Namikoshi, M.
Absolute structures of wedelolide derivatives and structure-activity relationships of protein tyrosine phosphatase 1B inhibitory ent-kaurene diterpenes from aerial parts of Wedelia spp. collected in Indonesia and Japan
Chem. Pharm. Bull.
66
682-687
2018
Homo sapiens (P18031), Homo sapiens
Wang, F.; Xue, R.; Li, X.; Hu, C.; Xia, Q.
Characterization of a protein tyrosine phosphatase as a host factor promoting baculovirus replication in silkworm, Bombyx mori
Dev. Comp. Immunol.
57
31-37
2016
Bombyx mori (Q75T82), Bombyx mori
Ottana, R.; Paoli, P.; Nass, A.; Lori, G.; Cardile, V.; Adornato, I.; Rotondo, A.; Graziano, A.C.E.; Wolber, G.; Maccari, R.
Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B in silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents
Eur. J. Med. Chem.
127
840-858
2017
Homo sapiens (P18031)
Ramirez-Tapia, A.L.; Baylon-Pacheco, L.; Espiritu-Gordillo, P.; Rosales-Encina, J.L.
Characterization of the protein tyrosine phosphatase PRL from Entamoeba histolytica
Exp. Parasitol.
159
168-182
2015
Entamoeba histolytica (A0A0A1EI83), Entamoeba histolytica, Entamoeba histolytica ATCC 30459 (A0A0A1EI83), Entamoeba histolytica HM1:IMSS (A0A0A1EI83)
Li, H.; Yang, D.; Ning, S.; Xu, Y.; Yang, F.; Yin, R.; Feng, T.; Han, S.; Guo, L.; Zhang, P.; Qu, W.; Guo, R.; Song, C.; Xiao, P.; Zhou, C.; Xu, Z.; Sun, J.P.; Yu, X.
Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways
FASEB J.
32
73-82
2018
Homo sapiens (Q05209), Homo sapiens
Seifried, A.; Bergeron, A.; Boivin, B.; Gohla, A.
Reversible oxidation controls the activity and oligomeric state of the mammalian phosphoglycolate phosphatase AUM
Free Radic. Biol. Med.
97
75-84
2016
Mus musculus (Q8CHP8)
Schneble, N.; Mueller, J.; Kliche, S.; Bauer, R.; Wetzker, R.; Boehmer, F.D.; Wang, Z.Q.; Mueller, J.P.
The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase
Glia
65
416-428
2017
Mus musculus (Q64455), Mus musculus C57BL/6 (Q64455)
Leitherer, S.; Clos, J.; Liebler-Tenorio, E.M.; Schleicher, U.; Bogdan, C.; Soulat, D.
Characterization of the protein tyrosine phosphatase LmPRL-1 secreted by Leishmania major via the exosome pathway
Infect. Immun.
85
e00084-17
2017
Leishmania major (Q4QEZ7), Leishmania major, Leishmania major MHOM/IL/81/FEBNI (Q4QEZ7)
Janczarek, M.; Vinardell, J.M.; Lipa, P.; Karas, M.
Hanks-type Serine/threonine protein kinases and phosphatases in bacteria roles in signaling and adaptation to various environments
Int. J. Mol. Sci.
19
2872-2901
2018
Escherichia coli (P55798), Pseudomonas aeruginosa (Q9HXC7), Pseudomonas aeruginosa ATCC 15692 (Q9HXC7), Pseudomonas aeruginosa 1C (Q9HXC7), Pseudomonas aeruginosa PRS 101 (Q9HXC7), Pseudomonas aeruginosa DSM 22644 (Q9HXC7), Pseudomonas aeruginosa CIP 104116 (Q9HXC7), Pseudomonas aeruginosa LMG 12228 (Q9HXC7), Pseudomonas aeruginosa JCM 14847 (Q9HXC7)
Wang, H.; Gu, C.; Rolfes, R.J.; Jessen, H.J.; Shears, S.B.
Structural and biochemical characterization of Siw14 a protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates
J. Biol. Chem.
293
6905-6914
2018
Saccharomyces cerevisiae (P53965), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P53965)
Hon, J.; Hwang, M.S.; Charnetzki, M.A.; Rashed, I.J.; Brady, P.B.; Quillin, S.; Makinen, M.W.
Kinetic characterization of the inhibition of protein tyrosine phosphatase-1B by vanadyl (VO2+) chelates
J. Biol. Inorg. Chem.
22
1267-1279
2017
Homo sapiens (P18031)
Ahmad, Z.; Morona, R.; Standish, A.J.
In vitro characterization and identification of potential substrates of a low molecular weight protein tyrosine phosphatase in Streptococcus pneumoniae
Microbiology
164
697-703
2018
Streptococcus pneumoniae D39 (A0A0H2ZQ64), Streptococcus pneumoniae D39 NCTC 7466 (A0A0H2ZQ64)
Kant, S.; Agarwal, S.; Pancholi, P.; Pancholi, V.
The Streptococcus pyogenes orphan protein tyrosine phosphatase, SP-PTP, possesses dual specificity and essential virulence regulatory functions
Mol. Microbiol.
97
515-540
2015
Streptococcus pyogenes serotype M28 (Q48VV6), Streptococcus pyogenes serotype M1 (Q9A1Y0), Streptococcus pyogenes serotype M28 MGAS6180 (Q48VV6)
Sarabia-Sanchez, M.J.; Trejo-Soto, P.J.; Velazquez-Lopez, J.M.; Carvente-Garcia, C.; Castillo, R.; Hernandez-Campos, A.; Avitia-Dominguez, C.; Enriquez-Mendiola, D.; Sierra-Campos, E.; Valdez-Solana, M.; Salas-Pacheco, J.M.; Tellez-Valencia, A.
Novel mixed-type inhibitors of protein tyrosine phosphatase 1B. Kinetic and computational studies
Molecules
22
2262-2278
2017
Homo sapiens (P18031)
Singh, N.; Yadav, S.; Rathaur, S.
Identification and characterization of novel membrane-bound PRL protein tyrosine phosphatases from Setaria cervi, a bovine filarial parasite
Parasitol. Res.
114
4267-4279
2015
Setaria cervi
Clarke, F.; Jordan, C.K.; Gutierrez-Martinez, E.; Bibby, J.A.; Sanchez-Blanco, C.; Cornish, G.H.; Dai, X.; Rawlings, D.J.; Zamoyska, R.; Guermonprez, P.; Cope, A.P.; Purvis, H.A.
Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells
PLoS ONE
12
e0186625
2017
Mus musculus (E9QAS3), Mus musculus, Mus musculus C57BL/6 (E9QAS3)
Yun, H.Y.; Lee, J.; Kim, H.; Ryu, H.; Shin, H.C.; Oh, B.H.; Ku, B.; Kim, S.J.
Structural study reveals the temperature-dependent conformational flexibility of Tk-PTP, a protein tyrosine phosphatase from Thermococcus kodakaraensis KOD1
PLoS ONE
13
e0197635
2018
Thermococcus kodakarensis (Q8X270), Thermococcus kodakarensis JCM 12380 (Q8X270), Thermococcus kodakarensis ATCC BAA-918 (Q8X270)
Jiang, H.; Sui, Y.; Cui, Y.; Lin, P.; Li, W.; Xing, S.; Wang, D.; Hu, M.; Fu, X.
Expression, purification, and characterization of human osteoclastic protein-tyrosine phosphatase catalytic domain in Escherichia coli
Protein Expr. Purif.
107
7-12
2015
Homo sapiens (P23469), Homo sapiens
Margenat, M.; Labandera, A.M.; Gil, M.; Carrion, F.; Purificacao, M.; Razzera, G.; Portela, M.M.; Obal, G.; Terenzi, H.; Pritsch, O.; Duran, R.; Ferreira, A.M.; Villarino, A.
New potential eukaryotic substrates of the mycobacterial protein tyrosine phosphatase PtpA hints of a bacterial modulation of macrophage bioenergetics state
Sci. Rep.
5
8819
2015
Mycobacterium tuberculosis (P9WIA1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WIA1), Mycobacterium tuberculosis ATCC 25618 (P9WIA1)
Segerer, G.; Hadamek, K.; Zundler, M.; Fekete, A.; Seifried, A.; Mueller, M.J.; Koentgen, F.; Gessler, M.; Jeanclos, E.; Gohla, A.
An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation
Sci. Rep.
6
35160
2016
Mus musculus (Q8CHP8)
Parker, E.J.
The molecular basis for the substrate specificity of protein tyrosine phosphatase PTPN3
Structure
23
608-609
2015
Homo sapiens (P26045)
Chen, K.E.; Li, M.Y.; Chou, C.C.; Ho, M.R.; Chen, G.C.; Meng, T.C.; Wang, A.H.
Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases
Structure
23
653-664
2015
Homo sapiens (P18031), Homo sapiens (P26045), Homo sapiens (Q12923), Homo sapiens (Q15678), Homo sapiens (Q16825)
Temel, D.B.; Dutta, K.; Alphonse, S.; Nourikyan, J.; Grangeasse, C.; Ghose, R.
Regulatory interactions between a bacterial tyrosine kinase and its cognate phosphatase
J. Biol. Chem.
288
15212-15228
2013
Escherichia coli (P0AAB2), Escherichia coli
Wright, C.J.; Xue, P.; Hirano, T.; Liu, C.; Whitmore, S.E.; Hackett, M.; Lamont, R.J.
Characterization of a bacterial tyrosine kinase in Porphyromonas gingivalis involved in polymicrobial synergy
MicrobiologyOpen
3
383-394
2014
Porphyromonas gingivalis (B2RKZ9), Porphyromonas gingivalis, Porphyromonas gingivalis DSM 20709 (B2RKZ9)
Pereira, S.; Santos, M.; Leite, J.; Flores, C.; Eisfeld, C.; Buettel, Z.; Mota, R.; Rossi, F.; De Philippis, R.; Gales, L.; Morais-Cabral, J.; Tamagnini, P.
The role of the tyrosine kinase Wzc (Sll0923) and the phosphatase Wzb (Slr0328) in the production of extracellular polymeric substances (EPS) by Synechocystis PCC 6803
MicrobiologyOpen
8
e00753
2019
Synechocystis sp. PCC 6803 (Q55535)
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