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3.1.3.48: protein-tyrosine-phosphatase

This is an abbreviated version!
For detailed information about protein-tyrosine-phosphatase, go to the full flat file.

Word Map on EC 3.1.3.48

Reaction

[a protein]-tyrosine phosphate
+
H2O
=
[a protein]-tyrosine
 +
phosphate

Synonyms

70Z-SHP, acid phosphatase, acid phosphatase activity, acid phosphatase ortholog, acid tyrosine phosphatase, alpha-PTP-PEST, AUM, Bd1204, BDP, Bmptp-h, Brain-derived phosphatase, BVP, CAPTPase, CD148, CD148 antigen, CD45, CD45 antigen, CD45 protein tyrosine phosphatase, Cdc25 phosphatase, Cdc25-like protein, Cdc25A, Cdc25B, Cdc25B phosphatase, Cdc25C, CDK2-associated dual specificity phosphatase, Ch-1PTPase, chick retinal tyrosine phosphatase-2, cold-active protein tyrosine phosphatase, CPTP1, CQMa102 phosphatase, Cryp-2, CRYP-2/PTPRO, CRYP-2/receptor-type tyrosine-protein phosphatase O, cysteine-dependent protein tyrosine phosphatase, cyt-PTPepsilon, density-enhanced phosphatase-1, DEP-1, DEP-1 phosphatase, DLAR, dPTP61F, DSP, DSP18, dual specificity phosphatase, Dual specificity phosphatase Cdc25A, Dual specificity phosphatase Cdc25B, Dual specificity phosphatase Cdc25C, dual specificity protein phosphatase, dual specificity protein phosphatase 23, dual specificity protein phosphatase 3, Dual specificity protein phosphatase hVH1, Dual specificity protein phosphatase hVH2, Dual specificity protein phosphatase hVH3, Dual specificity protein phosphatase PYST1, Dual specificity protein phosphatase PYST2, Dual specificity protein phosphatase VHR, dual-specificity (Thr/Tyr) MAPK protein phosphatase, dual-specificity phosphatase, dual-specificity protein phosphatase, dual-specificity protein tyrosine phosphatase 18, Dual-specificity tyrosine phosphatase TS-DSP6, Dual-specificity tyrosine phosphatase YVH1, DUSP, ED-Eya2, EhPRL, EpsB, ES cell phosphatase, FAP-1, Fap1, FLP1, GLEPP-1, GLEPP1, HAP, HCP, HD-PTP, Hematopoietic cell protein-tyrosine phosphatase, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, hematopoietic protein tyrosine phosphatase, Hematopoietic protein-tyrosine phosphatase, hematopoietic tyrosine phosphatase, HEPTP, His domain protein tyrosine phosphatase, histidine acid phosphatase, histidine domain-protein tyrosine phosphatase, HPTP beta-like tyrosine phosphatase, HPTP eta, HPTPbeta, HPTPbeta-CD, hPTPE1, IA-2, IA-2A, IA-2beta, IAR, ICAAR, IF1, IF2, insulinoma associated protein tyrosine phosphatase 2, islet cell antigen-related PTP, Islet cell autoantigen related protein, KIM-containing PTP, KIM-PTP, kinase associated phosphatase, kinase interaction motif phosphatase, kinase interaction motif-containing protein tyrosine phosphatases, L-CA, LAR, Late protein H1, LCA, LCA-related phosphatase, LDP-3, leucocyte common antigen-related protein tyrosine phosphatase, Leukocyte antigen related, leukocyte common antigen-related, LmACR2, LMJF_16_0230, LmPRL-1, LMW PTPase, LMW-PTP, LMWPTP, low molecular mass dual specificity phosphatase 3, Low molecular weight cytosolic acid phosphatase, Low molecular weight phosphotyrosine protein phosphatase, low molecular weight protein tyrosine phosphatase, low molecular weight protein-tyrosine phosphatase A, low molecular weight protein-tyrosine-phosphatase, low molecular weight-PTP, low-molecular weight PTPase, low-molecular-weight protein tyrosine phosphatase, Lpt1, LRP, Lymphoid phosphatase, lymphoid-specific tyrosine phosphatase, LyP, M1851, MAP kinase phosphatase, MAP-kinase phosphatase CPG21, MAPK-specific tyrosine phosphatase, MEG, mitogen-activated protein kinase phosphatase, mitogen-activated protein kinase phosphatase-1, mitogen-activated protein kinase-specific tyrosine phosphatase, Mitosis initiation protein, Mitosis initiation protein MIH1, Mitotic inducer homolog, MKP, MKP-1, MKP-1 like protein tyrosine phosphatase, MKP-2, MKP-3, MKP-4, MKP-5, MKP-7, MKP-X, MKP1, MKP5-C, More, MPTP, MPTP-PEST, MPtpA, MPtpB, MSP, N3PTP, NC-PTPCOM1, Neural-specific protein-tyrosine phosphatase, non-receptor protein tyrosine phosphatase, ORF5, orphan protein tyrosine phosphatase, OST-PTP, osteoclastic protein-tyrosine phosphatase, P19-PTP, p52shc, p65 PTPepsilon, p66shc, p67 PTPepsilon, P80, PC12-PTP1, PCPTP1, PEST, PGN_1525, Pgp, Phogrin, Phosphacan, phosphatase of regenerating liver-3, phosphatase, phosphoprotein (phosphotyrosine), phosphatase, phosphotyrosine, phosphoprotein phosphatase (phosphotyrosine), phosphotyrosine histone phosphatase, phosphotyrosine phosphatase, Phosphotyrosine phosphatase 13, phosphotyrosine phosphatase 1B, phosphotyrosine protein phosphatase, phosphotyrosine-specific PP, phosphotyrosylprotein phosphatase, Pmp1p, PP2A, PPase, pphA, PPM, PPT-phosphatase, PRL, PRL-1, PRL-3, PRL-related protein tyrosine phosphatase, probable low molecular weight protein-tyrosine-phosphatase, protein of regenerating liver-related protein tyrosine phosphatase, Protein phosphatase 1B, protein phosphatase 2A, protein phosphotyrosine phosphatase, protein Tyr phosphatase, protein tyrosine phosphatase, protein tyrosine phosphatase 1B, protein tyrosine phosphatase A, protein tyrosine phosphatase alpha, protein tyrosine phosphatase B, protein tyrosine phosphatase beta, protein tyrosine phosphatase epsilon, protein tyrosine phosphatase eta, protein tyrosine phosphatase H1, protein tyrosine phosphatase N12, protein tyrosine phosphatase N3, protein tyrosine phosphatase ny, Protein tyrosine phosphatase receptor-type T, protein tyrosine phosphatase SHP-1, protein tyrosine phosphatase sigma, protein tyrosine phosphatase xi, protein tyrosine phosphatase, non-receptor type 1, protein tyrosine phosphatase, receptor-type, Z polypeptide 1, protein tyrosine phosphatase-1B, protein tyrosine phosphatase-2, protein tyrosine phosphatase-BL, protein tyrosine phosphatase-H2, Protein tyrosine phosphatase-NP, protein tyrosine phosphatase-PEST, Protein-protein-tyrosine phosphatase HA2, protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1B, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase 1E, Protein-tyrosine phosphatase 2C, Protein-tyrosine phosphatase 2E, Protein-tyrosine phosphatase 3CH134, protein-tyrosine phosphatase alpha, Protein-tyrosine phosphatase CL100, Protein-tyrosine phosphatase D1, Protein-tyrosine phosphatase ERP, Protein-tyrosine phosphatase G1, Protein-tyrosine phosphatase H1, Protein-tyrosine phosphatase LC-PTP, Protein-tyrosine phosphatase MEG1, Protein-tyrosine phosphatase MEG2, Protein-tyrosine phosphatase P19, Protein-tyrosine phosphatase PCPTP1, Protein-tyrosine phosphatase pez, Protein-tyrosine phosphatase PTP-RL10, Protein-tyrosine phosphatase PTP36, Protein-tyrosine phosphatase PTPL1, Protein-tyrosine phosphatase striatum-enriched, Protein-tyrosine phosphatase SYP, Protein-tyrosine-phosphatase SL, Protein-tyrosine-phosphate phosphohydrolase, Prp1, PrpA, PTEN, PTEN phosphoprotein phosphatase, PTK, PTP, PTP 1B, PTP epsilon, PTP IA-2beta, PTP-1B, PTP-1C, PTP-1D, PTP-2C, PTP-BAS, PTP-BL, PTP-E1, PTP-eta, PTP-F, PTP-H1, PTP-H2, PTP-HA2, PTP-like phytase, PTP-MEG2, PTP-NP, PTP-oc, PTP-PEST, PTP-phosphatase, PTP-SH2beta, PTP-SL, PTP-U2, PTP1, PTP1B, PTP1C, PTP1D, PTP1e, PTP1N13, PTP1N21, PTP2C, PTP3, PTP36, PtpA, PTPalpha, PTPase, PTPase YVH1, PTPase-MEG1, PTPase-MEG2, PtpB, PTPB1, PTPBAS, PTPbeta, PTPBR7, PTPD1, PTPepsilon, PTPepsilonC, PTPepsilonM, PTPeta, PTPetaCD, PTPG1, PTPgamma, PTPH1, PTPL1, PTPLP, PTPMEG, PTPN1, PTPN11, PTPN12, PTPN13, PTPN14, PTPN2, PTPN20 variant 15, PTPN21, PTPN22, PTPN23, PTPN3, PTPN4, PTPN4/PTP-MEG1, PTPN5, PTPN6, PTPN7, PTPN9, PTPNE6, PTPP, PTPPase, PTPPBSgamma, PTPPBSgamma-37, PTPPBSgamma-42, PTPRA, PTPRB, PTPRC, PTPRD, PTPRdelta, PTPRE, PTPRF, PTPRG, PTPRH, PTPRJ, PTPRK, PTPRM, PTPRN, PTPRN2, PTPRO, PTPRO, truncated, PTPRO-FL, PTPRomega, PTPROt, PTPRQ, PTPRR, PTPRS, PTPRT, PTPRU, PTPRV, PTPRZ, PTPRZ1, PTPS31, PTPsigma, PTPxi/RPTPbeta, PY protein phosphatase, Pyp1p, Pyp2p, R-PTP-alpha, R-PTP-beta, R-PTP-delta, R-PTP-epsilon, R-PTP-eta, R-PTP-gamma, R-PTP-kappa, R-PTP-mu, R-PTP-zeta, R2B phosphatase, receptor protein tyrosine phosphatase, receptor protein tyrosine phosphatase isoform delta, receptor protein tyrosine phosphatase isoform omega, receptor protein tyrosine phosphatase rho, receptor protein tyrosine phosphatase T, receptor protein tyrosine phosphatase {kappa}, receptor PTPepsilon, Receptor-linked protein-tyrosine phosphatase 10D, Receptor-linked protein-tyrosine phosphatase 99A, receptor-type protein tyrosine phosphatase J, Receptor-type protein-tyrosine phosphatase-kappa, receptor-type tyrosine-protein phosphatase R, reductant-inhibited PTPase1, RIP1, RNA/RNP complex-intereracting phosphatase, ROL B protein, RPTP, RPTP-BK, RPTPalpha, RPTPdelta, RPTPepsilon, RPTPgamma, RPTPkappa, RPTPlambda, RPTPmu, RPTPrho, RPTPrho/PTPRT, RPTPsigma, RPTPzeta, Saci-PTP, Saci0545, SAP1, Scr homology 2-containing tyrosine phosphatase, selective striatal enriched protein phosphatase, SH-PTP1, SH-PTP2, SH-PTP3, SH2 domain-containing tyrosine phosphatase-1, SH2 domain-containing tyrosine phosphatase-2, SHP, SHP-1, SHP-2, SHP1, SHP2, Siw14, Slr0328, Small tyrosine phosphatase, Small, acidic phosphotyrosine protein phosphatase, SP-PTP, Spd1837, SPD_1837, specific protein-tyrosine phosphatase, SPH-1, SPH-2, SPy_0036, SPy_0039, Src homology 2 domain-containing phosphatase-1, Src homology region 2 domain-containing phosphatase 1, Src homology-2 domain containing protein tyrosine phosphatase-1, Src homology-2 domain containing protein tyrosine phosphatase-2, STEP, STEP33, STEP46, STEP61, Stp1, striatal enriched protein tyrosine phosphatase, striatal-enriched protein-tyrosine phosphatase, striatal-enriched PTP, String protein, SynPTP, Syp, T cell protein tyrosine phosphatase, T-cell protein tyrosine phosphatase, T-cell protein-tyrosine phosphatase, T-cell PTP, T-DSP11, T200, TC PTP, TC-PTPase ´, TC48, TCPTP, TCPTP/TC45, TcPTP1, testis- and skeletal-muscle-specific DSP, testis- and skeletal-muscle-specific dual specificity protein phosphatase, Testis-and skeletal-muscle-specific DSP, Tk-PTP, TK0241, TMDP, TpbA, TypPT, tyrosine O-phosphate phosphatase, tyrosine phosphatase, tyrosine phosphatase alpha, Tyrosine phosphatase CBPTP, tyrosine phosphatase epsilon, tyrosine phosphatase IA-2, tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1, tyrosine phosphatase-1B, tyrosine-protein phosphatase, tyrosine-protein phosphatase non-receptor type 22, tyrosine-protein phosphatase non-receptor type 5, tyrosine-specific MAPK phosphatase, tyrosylprotein phosphatase, vaccinia H1-related PTP, VE-PTP, VHR, VHZ, Wzb, YopH, YwlE, YwqE, [phosphotyrosine]protein phosphatase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.48 protein-tyrosine-phosphatase

Cloned

Cloned on EC 3.1.3.48 - protein-tyrosine-phosphatase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
catalytic domain of receptor-like protein tyrosine phosphatase
DNA and amino acid sequence determination and analysis, sequence comparisons, expression of the His6-tagged wild-type and mutant enzymes in Escherichia coli strain BL21(DE3), subcloning in strain DH5alpha
enzyme SHP-1 expression in Escherichia coli strain BL21 (DE3)
-
enzyme SHPTP1 and its catalytic domain, lacking the N-terminal SH2-domains, expression in Escherichia coli
-
expressed in CHO cells and L6 cells
expressed in COS-7 cells
expressed in Escherichia coli
expressed in Escherichia coli AD494 (DE3) cells
expressed in Escherichia coli BL21 (DE3) cells
expressed in Escherichia coli BL21 and HEK293T cells
-
expressed in Escherichia coli BL21 cells
-
expressed in Escherichia coli BL21 Codon Plus cells
-
expressed in Escherichia coli BL21 DE3 cells
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli BL21(DE3) cells and HEK-293T cells
-
expressed in Escherichia coli BL21(DE3) codon plus cells as GST fusion protein
-
expressed in Escherichia coli BL21(DE3)pLysS cells
expressed in Escherichia coli BL21-CodonPlus (DE3) cells
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells
-
expressed in Escherichia coli DH5alpha cells
expressed in Escherichia coli DH5alpha cells and HEK-293 cells as GST fusion protein
-
expressed in Escherichia coli strain BJ5183
expressed in Escherichia coli strain BL21 (DE3)
-
expressed in Escherichia coli strain BL21(DE3)
-
expressed in HCT-116 colon cancer cell line
-
expressed in HEK293 cells
-
expressed in HEK293T cells
-
expressed in HUVEC cells, overexpression of PTP1B stabilizes VE-cadherin-mediated cell-cell adhesions by reducing VE-cadherin tyrosine phosphorylation
-
expressed in in Ba/F3 cells and in primary bone marrow hematopoietic progenitor cells
-
expressed in insect cells
-
expressed in insect cells and HEK-293T cells
-
expressed in K-562 cells
expressed in PT67 murine stem cell virus
-
expressed in rat INS-1 cells
-
expressed in Rattus norvegicus PC-12 cells
-
expressed in Saccharomyces cerevisiae and Arabidopsis thaliana
expressed in Saccharomyces cerevisiae YPH499 cells
expressed in U-937 cells
-
expression in Escherichia coli
expression in Escherichia coli Rosetta (DE3)-RIL
expression in Escherichia coli strain BL21(DE3)
-
expression in Escherichiachia coli
expression in Jurkat cells
-
expression in Sf9 cells
-
expression of N-terminally His-tagged enzyme mutant C227S, expression of Myc-tagged lymphoid-specific tyrosine phosphatase in HEK-293 cells, co-expression with SKAP-HOM, a cytosolic adaptor protein required for proper activation of the immune system, a bona fide Lyp substrate
-
expression of PTP2C and DELTASH2-PTP2C in Escherichia coli
-
expression of splicing variant SV3 of LMW-PTP in Escherichia coli
-
expression of the active and soluble PTPase in Escherichia coli strain BL21(DE3)
expression of the His-tagged enzyme in Escherichia coli strain BL21(DE3)
expression of truncated forms encoding the catalytic domain which is independent of the regulatory influence of the C-terminus
-
expression of wild-type and mutant FLP1 in K562 cells
-
expression of wild-type and mutant PTEN in Spodoptera fruiperda Sf9 cells
-
expression of Yop51 and Yop51*, a C235R point mutation and expression of the catalytic domain, residues 163-468 in Escherichia coli
-
full length form and a truncated form lacking the SH-domains and exhibiting a higher catalytic activity, GenBank, EMBL Data Bank L07527
GenBank D64141, exclusively expressed in spermatocytes
-
gene Bmptp-h, functional recombinant overexpression of N-terminally FLAG-tagged enzyme in Bombyx mori larvae, transfection via dsRNA injection into larvae or viral infection method, quantitative real-time PCR expression analysis and expression profile of Bmptp-h during the development and in different tissues, overview. Recombinant expression of Flag-tagged BmPTP-h in BmE cells via viral transfection, overexpression of Bmptp-h enhances Bombyx mori nucleopolyhedrovirus (BmNPV) replication in BmE cells
gene CvBV202, located on segment S2 of CvBV genome, DNA and amino acid sequence determination and analysis. Host tissue-specific patterns of CvBV202 gene expression, overview. Expression of eGFP-tagged enzyme in Tn-5B1-4 cells via baculovirus transfection
-
gene ehprl, RT-PCR cloning, DNA and amino acid sequence determination and analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3) pLyS
gene PRL-1, the gene is located on chromosome 16, sequence comparisons and phylogenetic analysis, recombinant expression of His6-LmPRL-1 in Escherichia coli, recombinant ectopical expression of hemagglutinin (HA3)-tagged LmPRL-1 in Leishmania major parasites, HA3-tagged LmPRL-1 is secreted by Leishmania major promastigotes inside exosomes
gene ptp-H2, DNA and amino acid sequence determination and analysis, recombinant expression of His-tagged wild-type and mutant PTP-H2 in Escherichia coli cells as non-fusion or thioredoxinfusion proteins
Bracoviriform demolitoris
-
gene PTP1B, recombinant expression of C-terminally His-tagged wild-type and mutant enzymes (PTP1B residues 1-321) in Escherichia coli strain BL21(DE3)
gene ptpA, recombinant expression of His-tagged wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)
gene ptpase, recombinant expression in Pichia pastoris
gene PTPN12, recombinant expression of wild-type and mutant GST-tagged enzymes in Escherichia coli
gene Ptpn22, real-time PCR expression analysis
gene PTPN6, recombinant expression of wild-type full-length enzyme and isolated catalytic enzyme domain SHP-1cat, and of V451M mutant full-length enzyme and isolated catalytic enzyme domain SHP-1cat in Escherichia coli
gene PTPRD, sequence comparisons and phylogenetic analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3), subcloning in Escherichia coli strain DH5alpha
gene PTPRE, located on chromosome 12p12-p13, recombinant expression of isolated C-terminally His6-tagged intracellular catalytic domain of PTP-oc (DELTAPTP-oc) in Escherichia coli strain BL21(DE3), method evaluation
gene Ptprj, quantitative PCR expression analysis
gene PTPRR, sequence comparisons and phylogenetic analysis, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3), subcloning in Escherichia coli strain DH5alpha
gene siw14, recombinant expression of His6-MBP-tagged wild-type and mutant enzymes in Escherichia coli
gene SPD_1837, recombinant expression in Escherichia coli strain BL21(DE3)
gene SPy_0036, quantitative real time PCR expression analysis, recombinant expression of His-tagged wild-type and mutant enzymes in Escherichia coli
gene SPy_0039, quantitative real time PCR expression analysis, recombinant expression of His-tagged wild-type and mutant enzymes in Escherichia coli
gene SPy_0039, recombinant expression of His-tagged enzyme Sp-PTP in Escherichia coli strain BL21(DE3)
His-tagged enzyme expression in Escherichia coli
-
intracellular catalytic domain of protein tyrosine phosphatase ny
-
lymphoid-specific enzyme
overexpression of PTP1B in HEK-293 cells
-
p52shc and p66shc expression analysis, overexpression of p66shc
-
receptor-type protein tyrosine phosphatase, isoforms RPTPgamma-A, RPTPgamma-B, RPTPgamma-C, RPTPgamma-S, expression in COS7 cells
-
recombinant expression of His-tagged wild-type and mutant enzymes in Escherichia coli strain BL21(DE3) RIL
recombinant expression of the TEV protease-cleavable, N-terminally His6-tagged maltose-binding protein-PTPepsilon D1(Ser107-Gly398) fusion protein and of wild-type and mutant TEV protease-cleavable, N-terminally His6-tagged-maltose-binding protein D2 domain of PTPepsilon D2(Gly425-Lys700) in Escherichia coli strain Rosetta 2 (DE3)
recombinant expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2) in Escherichia coli strains GI698 and GI724
STEP46 is expressed in Escherichia coli
-