3.1.3.48: protein-tyrosine-phosphatase This is an abbreviated version! For detailed information about protein-tyrosine-phosphatase, go to the full flat file .
Reaction
[a protein]-tyrosine phosphate +
H2O =
[a protein]-tyrosine +
phosphate
Synonyms 70Z-SHP, acid phosphatase, acid phosphatase activity, acid phosphatase ortholog, acid tyrosine phosphatase, alpha-PTP-PEST, AUM, Bd1204, BDP, Bmptp-h, Brain-derived phosphatase, BVP, CAPTPase, CD148, CD148 antigen, CD45, CD45 antigen, CD45 protein tyrosine phosphatase, Cdc25 phosphatase, Cdc25-like protein, Cdc25A, Cdc25B, Cdc25B phosphatase, Cdc25C, CDK2-associated dual specificity phosphatase, Ch-1PTPase, chick retinal tyrosine phosphatase-2, cold-active protein tyrosine phosphatase, CPTP1, CQMa102 phosphatase, Cryp-2, CRYP-2/PTPRO, CRYP-2/receptor-type tyrosine-protein phosphatase O, cysteine-dependent protein tyrosine phosphatase, cyt-PTPepsilon, density-enhanced phosphatase-1, DEP-1, DEP-1 phosphatase, DLAR, dPTP61F, DSP, DSP18, dual specificity phosphatase, Dual specificity phosphatase Cdc25A, Dual specificity phosphatase Cdc25B, Dual specificity phosphatase Cdc25C, dual specificity protein phosphatase, dual specificity protein phosphatase 23, dual specificity protein phosphatase 3, Dual specificity protein phosphatase hVH1, Dual specificity protein phosphatase hVH2, Dual specificity protein phosphatase hVH3, Dual specificity protein phosphatase PYST1, Dual specificity protein phosphatase PYST2, Dual specificity protein phosphatase VHR, dual-specificity (Thr/Tyr) MAPK protein phosphatase, dual-specificity phosphatase, dual-specificity protein phosphatase, dual-specificity protein tyrosine phosphatase 18, Dual-specificity tyrosine phosphatase TS-DSP6, Dual-specificity tyrosine phosphatase YVH1, DUSP, ED-Eya2, EhPRL, EpsB, ES cell phosphatase, FAP-1, Fap1, FLP1, GLEPP-1, GLEPP1, HAP, HCP, HD-PTP, Hematopoietic cell protein-tyrosine phosphatase, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, hematopoietic protein tyrosine phosphatase, Hematopoietic protein-tyrosine phosphatase, hematopoietic tyrosine phosphatase, HEPTP, His domain protein tyrosine phosphatase, histidine acid phosphatase, histidine domain-protein tyrosine phosphatase, HPTP beta-like tyrosine phosphatase, HPTP eta, HPTPbeta, HPTPbeta-CD, hPTPE1, IA-2, IA-2A, IA-2beta, IAR, ICAAR, IF1, IF2, insulinoma associated protein tyrosine phosphatase 2, islet cell antigen-related PTP, Islet cell autoantigen related protein, KIM-containing PTP, KIM-PTP, kinase associated phosphatase, kinase interaction motif phosphatase, kinase interaction motif-containing protein tyrosine phosphatases, L-CA, LAR, Late protein H1, LCA, LCA-related phosphatase, LDP-3, leucocyte common antigen-related protein tyrosine phosphatase, Leukocyte antigen related, leukocyte common antigen-related, LmACR2, LMJF_16_0230, LmPRL-1, LMW PTPase, LMW-PTP, LMWPTP, low molecular mass dual specificity phosphatase 3, Low molecular weight cytosolic acid phosphatase, Low molecular weight phosphotyrosine protein phosphatase, low molecular weight protein tyrosine phosphatase, low molecular weight protein-tyrosine phosphatase A, low molecular weight protein-tyrosine-phosphatase, low molecular weight-PTP, low-molecular weight PTPase, low-molecular-weight protein tyrosine phosphatase, Lpt1, LRP, Lymphoid phosphatase, lymphoid-specific tyrosine phosphatase, LyP, M1851, MAP kinase phosphatase, MAP-kinase phosphatase CPG21, MAPK-specific tyrosine phosphatase, MEG, mitogen-activated protein kinase phosphatase, mitogen-activated protein kinase phosphatase-1, mitogen-activated protein kinase-specific tyrosine phosphatase, Mitosis initiation protein, Mitosis initiation protein MIH1, Mitotic inducer homolog, MKP, MKP-1, MKP-1 like protein tyrosine phosphatase, MKP-2, MKP-3, MKP-4, MKP-5, MKP-7, MKP-X, MKP1, MKP5-C, More, MPTP, MPTP-PEST, MPtpA, MPtpB, MSP, N3PTP, NC-PTPCOM1, Neural-specific protein-tyrosine phosphatase, non-receptor protein tyrosine phosphatase, ORF5, orphan protein tyrosine phosphatase, OST-PTP, osteoclastic protein-tyrosine phosphatase, P19-PTP, p52shc, p65 PTPepsilon, p66shc, p67 PTPepsilon, P80, PC12-PTP1, PCPTP1, PEST, PGN_1525, Pgp, Phogrin, Phosphacan, phosphatase of regenerating liver-3, phosphatase, phosphoprotein (phosphotyrosine), phosphatase, phosphotyrosine, phosphoprotein phosphatase (phosphotyrosine), phosphotyrosine histone phosphatase, phosphotyrosine phosphatase, Phosphotyrosine phosphatase 13, phosphotyrosine phosphatase 1B, phosphotyrosine protein phosphatase, phosphotyrosine-specific PP, phosphotyrosylprotein phosphatase, Pmp1p, PP2A, PPase, pphA, PPM, PPT-phosphatase, PRL, PRL-1, PRL-3, PRL-related protein tyrosine phosphatase, probable low molecular weight protein-tyrosine-phosphatase, protein of regenerating liver-related protein tyrosine phosphatase, Protein phosphatase 1B, protein phosphatase 2A, protein phosphotyrosine phosphatase, protein Tyr phosphatase, protein tyrosine phosphatase, protein tyrosine phosphatase 1B, protein tyrosine phosphatase A, protein tyrosine phosphatase alpha, protein tyrosine phosphatase B, protein tyrosine phosphatase beta, protein tyrosine phosphatase epsilon, protein tyrosine phosphatase eta, protein tyrosine phosphatase H1, protein tyrosine phosphatase N12, protein tyrosine phosphatase N3, protein tyrosine phosphatase ny, Protein tyrosine phosphatase receptor-type T, protein tyrosine phosphatase SHP-1, protein tyrosine phosphatase sigma, protein tyrosine phosphatase xi, protein tyrosine phosphatase, non-receptor type 1, protein tyrosine phosphatase, receptor-type, Z polypeptide 1, protein tyrosine phosphatase-1B, protein tyrosine phosphatase-2, protein tyrosine phosphatase-BL, protein tyrosine phosphatase-H2, Protein tyrosine phosphatase-NP, protein tyrosine phosphatase-PEST, Protein-protein-tyrosine phosphatase HA2, protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1B, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase 1E, Protein-tyrosine phosphatase 2C, Protein-tyrosine phosphatase 2E, Protein-tyrosine phosphatase 3CH134, protein-tyrosine phosphatase alpha, Protein-tyrosine phosphatase CL100, Protein-tyrosine phosphatase D1, Protein-tyrosine phosphatase ERP, Protein-tyrosine phosphatase G1, Protein-tyrosine phosphatase H1, Protein-tyrosine phosphatase LC-PTP, Protein-tyrosine phosphatase MEG1, Protein-tyrosine phosphatase MEG2, Protein-tyrosine phosphatase P19, Protein-tyrosine phosphatase PCPTP1, Protein-tyrosine phosphatase pez, Protein-tyrosine phosphatase PTP-RL10, Protein-tyrosine phosphatase PTP36, Protein-tyrosine phosphatase PTPL1, Protein-tyrosine phosphatase striatum-enriched, Protein-tyrosine phosphatase SYP, Protein-tyrosine-phosphatase SL, Protein-tyrosine-phosphate phosphohydrolase, Prp1, PrpA, PTEN, PTEN phosphoprotein phosphatase, PTK, PTP, PTP 1B, PTP epsilon, PTP IA-2beta, PTP-1B, PTP-1C, PTP-1D, PTP-2C, PTP-BAS, PTP-BL, PTP-E1, PTP-eta, PTP-F, PTP-H1, PTP-H2, PTP-HA2, PTP-like phytase, PTP-MEG2, PTP-NP, PTP-oc, PTP-PEST, PTP-phosphatase, PTP-SH2beta, PTP-SL, PTP-U2, PTP1, PTP1B, PTP1C, PTP1D, PTP1e, PTP1N13, PTP1N21, PTP2C, PTP3, PTP36, PtpA, PTPalpha, PTPase, PTPase YVH1, PTPase-MEG1, PTPase-MEG2, PtpB, PTPB1, PTPBAS, PTPbeta, PTPBR7, PTPD1, PTPepsilon, PTPepsilonC, PTPepsilonM, PTPeta, PTPetaCD, PTPG1, PTPgamma, PTPH1, PTPL1, PTPLP, PTPMEG, PTPN1, PTPN11, PTPN12, PTPN13, PTPN14, PTPN2, PTPN20 variant 15, PTPN21, PTPN22, PTPN23, PTPN3, PTPN4, PTPN4/PTP-MEG1, PTPN5, PTPN6, PTPN7, PTPN9, PTPNE6, PTPP, PTPPase, PTPPBSgamma, PTPPBSgamma-37, PTPPBSgamma-42, PTPRA, PTPRB, PTPRC, PTPRD, PTPRdelta, PTPRE, PTPRF, PTPRG, PTPRH, PTPRJ, PTPRK, PTPRM, PTPRN, PTPRN2, PTPRO, PTPRO, truncated, PTPRO-FL, PTPRomega, PTPROt, PTPRQ, PTPRR, PTPRS, PTPRT, PTPRU, PTPRV, PTPRZ, PTPRZ1, PTPS31, PTPsigma, PTPxi/RPTPbeta, PY protein phosphatase, Pyp1p, Pyp2p, R-PTP-alpha, R-PTP-beta, R-PTP-delta, R-PTP-epsilon, R-PTP-eta, R-PTP-gamma, R-PTP-kappa, R-PTP-mu, R-PTP-zeta, R2B phosphatase, receptor protein tyrosine phosphatase, receptor protein tyrosine phosphatase isoform delta, receptor protein tyrosine phosphatase isoform omega, receptor protein tyrosine phosphatase rho, receptor protein tyrosine phosphatase T, receptor protein tyrosine phosphatase {kappa}, receptor PTPepsilon, Receptor-linked protein-tyrosine phosphatase 10D, Receptor-linked protein-tyrosine phosphatase 99A, receptor-type protein tyrosine phosphatase J, Receptor-type protein-tyrosine phosphatase-kappa, receptor-type tyrosine-protein phosphatase R, reductant-inhibited PTPase1, RIP1, RNA/RNP complex-intereracting phosphatase, ROL B protein, RPTP, RPTP-BK, RPTPalpha, RPTPdelta, RPTPepsilon, RPTPgamma, RPTPkappa, RPTPlambda, RPTPmu, RPTPrho, RPTPrho/PTPRT, RPTPsigma, RPTPzeta, Saci-PTP, Saci0545, SAP1, Scr homology 2-containing tyrosine phosphatase, selective striatal enriched protein phosphatase, SH-PTP1, SH-PTP2, SH-PTP3, SH2 domain-containing tyrosine phosphatase-1, SH2 domain-containing tyrosine phosphatase-2, SHP, SHP-1, SHP-2, SHP1, SHP2, Siw14, Slr0328, Small tyrosine phosphatase, Small, acidic phosphotyrosine protein phosphatase, SP-PTP, Spd1837, SPD_1837, specific protein-tyrosine phosphatase, SPH-1, SPH-2, SPy_0036, SPy_0039, Src homology 2 domain-containing phosphatase-1, Src homology region 2 domain-containing phosphatase 1, Src homology-2 domain containing protein tyrosine phosphatase-1, Src homology-2 domain containing protein tyrosine phosphatase-2, STEP, STEP33, STEP46, STEP61, Stp1, striatal enriched protein tyrosine phosphatase, striatal-enriched protein-tyrosine phosphatase, striatal-enriched PTP, String protein, SynPTP, Syp, T cell protein tyrosine phosphatase, T-cell protein tyrosine phosphatase, T-cell protein-tyrosine phosphatase, T-cell PTP, T-DSP11, T200, TC PTP, TC-PTPase ´, TC48, TCPTP, TCPTP/TC45, TcPTP1, testis- and skeletal-muscle-specific DSP, testis- and skeletal-muscle-specific dual specificity protein phosphatase, Testis-and skeletal-muscle-specific DSP, Tk-PTP, TK0241, TMDP, TpbA, TypPT, tyrosine O-phosphate phosphatase, tyrosine phosphatase, tyrosine phosphatase alpha, Tyrosine phosphatase CBPTP, tyrosine phosphatase epsilon, tyrosine phosphatase IA-2, tyrosine phosphatase Src homology region 2 domain-containing phosphatase 1, tyrosine phosphatase-1B, tyrosine-protein phosphatase, tyrosine-protein phosphatase non-receptor type 22, tyrosine-protein phosphatase non-receptor type 5, tyrosine-specific MAPK phosphatase, tyrosylprotein phosphatase, vaccinia H1-related PTP, VE-PTP, VHR, VHZ, Wzb, YopH, YwlE, YwqE, [phosphotyrosine]protein phosphatase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 3.1.3.48 - protein-tyrosine-phosphatase
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DADE(pY)LIPQQG + H2O
DADEYLIPQQG + phosphate
a physiological phosphopeptide substrate of enzyme PTP1B
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FMN + H2O
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lung enzyme
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nicotinic acetylcholine receptor + H2O
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i.e. nAChR
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paxilin tyrosine phosphate + H2O
paxilin tyrosine + phosphate
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PTPRT specifically regulates paxillin phosphorylation at Tyr88 in colorectal cancer cells
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?
phosphocaveolin-1 + H2O
caveolin-1 + phosphate
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phosphorylated at Y14
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phosphorylated alpha-actinin + H2O
alpha-actinin + phosphate
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phosphorylated AMP-activated protein kinase + H2O
AMP-activated protein kinase + phosphate
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PTPB1 is involved in AMPK regulation through its phosphorylation in a tissue-specific manner, overview
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phosphorylated CD3 epsilon + H2O
CD3 epsilon + phosphate
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phosphorylated epidermal growth factor receptor + H2O
epidermal growth factor receptor + phosphate
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inactivation of EGFR
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phosphorylated Gln3 + H2O
Gln3 + phosphate
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Siw14, in combination with the protein kinase Npr1, regulates the intracellular localization of Gln3
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?
phosphorylated IGF-I receptor + H2O
IGF-I receptor + phosphate
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isozyme p52shc
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phosphorylated Lck + H2O
Lck + phosphate
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component of the T cell receptor signaling pathway
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phosphorylated p130 Crk-associated substrate + H2O
p130 Crk-associated substrate + phosphate
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phosphorylated STAT1c + H2O
STAT1c + phosphate
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mode of STAT activation, whereby serine-threonine phosphorylation of the cognate protein tyrosine phosphatase PTP3 results in the inhibition of its activity, shifting the phosphorylation-dephosphorylation equilibrium in favour of phosphorylation, overview
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phosphorylated T cell antigen receptor zeta + H2O
T cell antigen receptor zeta + phosphate
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phosphorylated valosin containing protein + H2O
valosin containing protein + phosphate
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phosphorylated Vav + H2O
Vav + phosphate
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component of the T cell receptor signaling pathway
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phosphorylated Zap70 + H2O
Zap70 + phosphate
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protein-tyrosine kinase
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phosphotyrosine + H2O
tyrosine + phosphate
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lung enzyme
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phosphotyrosyl-STAT3 + H2O
STAT3 + phosphate
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signal transducers and activator of transcription 3, STAT3, is a transcription factor that is associated with survival, proliferation, chemoresistance, and angiogenesis of tumor cells
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?
Y527-phosphorylated Src + H2O
Src + phosphate
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?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
[ATP synthase]-tyrosine phosphate + H2O
[ATP synthase]-tyrosine + phosphate
[cytosolic 6-phosphofructokinase]-tyrosine phosphate + H2O
[cytosolic 6-phosphofructokinase]-tyrosine + phosphate
[diguanylate cyclase TpbB]-tyrosine phosphate + H2O
[diguanylate cyclase TpbB]-tyrosine + phosphate
[epidermal growth factor receptor 2]-tyrosine phosphate + H2O
[epidermal growth factor receptor 2]-tyrosine + phosphate
dephosphorylation of epidermal growth factor receptor 2 (HER2)-pY1196 site
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?
[epidermal growth factor receptor]-tyrosine phosphate + H2O
[epidermal growth factor receptor]-tyrosine + phosphate
[Eps15 peptide]-tyrosine phosphate + H2O
[Eps15 peptide]-tyrosine + phosphate
[FHA-1]-tyrosine phosphate + H2O
[FHA-1]-tyrosine + phosphate
[FYN kinase]-tyrosine phosphate + H2O
[FYN kinase]-tyrosine + phosphate
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?
[insulin receptor kinase]-tyrosine phosphate + H2O
[insulin receptor kinase]-tyrosine + phosphate
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?
[protein]-L-tyrosine phosphate + H2O
[protein]-L-tyrosine + phosphate
[protein]-tyrosine phosphate + H2O
[protein]-tyrosine + phosphate
[sulfide quinone oxidoreductase]-tyrosine phosphate + H2O
[sulfide quinone oxidoreductase]-tyrosine + phosphate
[trifunctional enzyme]-tyrosine phosphate + H2O
[trifunctional enzyme]-tyrosine + phosphate
additional information
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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?
[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[a protein]-tyrosine phosphate + H2O
[a protein]-tyrosine + phosphate
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[ATP synthase]-tyrosine phosphate + H2O
[ATP synthase]-tyrosine + phosphate
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[ATP synthase]-tyrosine phosphate + H2O
[ATP synthase]-tyrosine + phosphate
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[ATP synthase]-tyrosine phosphate + H2O
[ATP synthase]-tyrosine + phosphate
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[cytosolic 6-phosphofructokinase]-tyrosine phosphate + H2O
[cytosolic 6-phosphofructokinase]-tyrosine + phosphate
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?
[cytosolic 6-phosphofructokinase]-tyrosine phosphate + H2O
[cytosolic 6-phosphofructokinase]-tyrosine + phosphate
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?
[cytosolic 6-phosphofructokinase]-tyrosine phosphate + H2O
[cytosolic 6-phosphofructokinase]-tyrosine + phosphate
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[diguanylate cyclase TpbB]-tyrosine phosphate + H2O
[diguanylate cyclase TpbB]-tyrosine + phosphate
the substrate is involved in motility, biofilm formation
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[diguanylate cyclase TpbB]-tyrosine phosphate + H2O
[diguanylate cyclase TpbB]-tyrosine + phosphate
the substrate is involved in motility, biofilm formation
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[diguanylate cyclase TpbB]-tyrosine phosphate + H2O
[diguanylate cyclase TpbB]-tyrosine + phosphate
the substrate is involved in motility, biofilm formation
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?
[diguanylate cyclase TpbB]-tyrosine phosphate + H2O
[diguanylate cyclase TpbB]-tyrosine + phosphate
the substrate is involved in motility, biofilm formation
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[diguanylate cyclase TpbB]-tyrosine phosphate + H2O
[diguanylate cyclase TpbB]-tyrosine + phosphate
the substrate is involved in motility, biofilm formation
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?
[diguanylate cyclase TpbB]-tyrosine phosphate + H2O
[diguanylate cyclase TpbB]-tyrosine + phosphate
the substrate is involved in motility, biofilm formation
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?
[diguanylate cyclase TpbB]-tyrosine phosphate + H2O
[diguanylate cyclase TpbB]-tyrosine + phosphate
the substrate is involved in motility, biofilm formation
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?
[diguanylate cyclase TpbB]-tyrosine phosphate + H2O
[diguanylate cyclase TpbB]-tyrosine + phosphate
the substrate is involved in motility, biofilm formation
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[epidermal growth factor receptor]-tyrosine phosphate + H2O
[epidermal growth factor receptor]-tyrosine + phosphate
enzyme SP-PTP dephosphorylates the activated EGFR (170 kDa protein migrating at about 240 kDa) present in MDA-MB-231 cell lines
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[epidermal growth factor receptor]-tyrosine phosphate + H2O
[epidermal growth factor receptor]-tyrosine + phosphate
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[epidermal growth factor receptor]-tyrosine phosphate + H2O
[epidermal growth factor receptor]-tyrosine + phosphate
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[Eps15 peptide]-tyrosine phosphate + H2O
[Eps15 peptide]-tyrosine + phosphate
substrate is a phosphopeptide fragment of substrate epidermal growth factor receptor. Eps15 is a scaffolding adaptor that regulates endocytosis and trafficking of the EGFR and is a substrate for enzyme PTPN3
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[Eps15 peptide]-tyrosine phosphate + H2O
[Eps15 peptide]-tyrosine + phosphate
substrate is a phosphopeptide fragment of substrate epidermal growth factor receptor. Eps15 is a scaffolding adaptor that regulates endocytosis and trafficking of the EGFR and is a substrate for enzyme PTPN3
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[FHA-1]-tyrosine phosphate + H2O
[FHA-1]-tyrosine + phosphate
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[FHA-1]-tyrosine phosphate + H2O
[FHA-1]-tyrosine + phosphate
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[FHA-1]-tyrosine phosphate + H2O
[FHA-1]-tyrosine + phosphate
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[FHA-1]-tyrosine phosphate + H2O
[FHA-1]-tyrosine + phosphate
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[FHA-1]-tyrosine phosphate + H2O
[FHA-1]-tyrosine + phosphate
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[FHA-1]-tyrosine phosphate + H2O
[FHA-1]-tyrosine + phosphate
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[FHA-1]-tyrosine phosphate + H2O
[FHA-1]-tyrosine + phosphate
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[FHA-1]-tyrosine phosphate + H2O
[FHA-1]-tyrosine + phosphate
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[protein]-L-tyrosine phosphate + H2O
[protein]-L-tyrosine + phosphate
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[protein]-L-tyrosine phosphate + H2O
[protein]-L-tyrosine + phosphate
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[protein]-tyrosine phosphate + H2O
[protein]-tyrosine + phosphate
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[protein]-tyrosine phosphate + H2O
[protein]-tyrosine + phosphate
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[protein]-tyrosine phosphate + H2O
[protein]-tyrosine + phosphate
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[protein]-tyrosine phosphate + H2O
[protein]-tyrosine + phosphate
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[protein]-tyrosine phosphate + H2O
[protein]-tyrosine + phosphate
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[protein]-tyrosine phosphate + H2O
[protein]-tyrosine + phosphate
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[protein]-tyrosine phosphate + H2O
[protein]-tyrosine + phosphate
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[protein]-tyrosine phosphate + H2O
[protein]-tyrosine + phosphate
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[sulfide quinone oxidoreductase]-tyrosine phosphate + H2O
[sulfide quinone oxidoreductase]-tyrosine + phosphate
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[sulfide quinone oxidoreductase]-tyrosine phosphate + H2O
[sulfide quinone oxidoreductase]-tyrosine + phosphate
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[sulfide quinone oxidoreductase]-tyrosine phosphate + H2O
[sulfide quinone oxidoreductase]-tyrosine + phosphate
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[trifunctional enzyme]-tyrosine phosphate + H2O
[trifunctional enzyme]-tyrosine + phosphate
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[trifunctional enzyme]-tyrosine phosphate + H2O
[trifunctional enzyme]-tyrosine + phosphate
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[trifunctional enzyme]-tyrosine phosphate + H2O
[trifunctional enzyme]-tyrosine + phosphate
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additional information
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PTP is an element of the abscisic acid signaling pathway that leads to stomatal closure
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Bracoviriform demolitoris
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PTP-H2 functions as an inhibitor of phagocytosis, PTP-H2 mediates cell death of infected Sf-21 cells, expression of PTP-H2 triggers mitochondrial membrane depolarisation and caspase-dependent apoptosis
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STATc becomes tyrosine phosphorylated and accumulates in the nucleus when Dictyostelium cells are exposed to the prestalk cell inducer Differentiation inducing factor 1, DIF-1, or are subjected to hyperosmotic stress
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PTPases regulate the ligand-induced autophosphorylation of PTK growth factor receptors, the phosphotyrosine-mediated binding s of src homology 2 (SH2)-domain-containing proteins to autophosphorylated PTK growth factor receptors and the activation state of the src family pf PTK
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LMW-PTP is involved in the negative regulation of the mitogenic stimulus starting from the activated PDGF receptor. The interaction between LMW-PTP results in the dephosphorylation of the PDGF-R phosphortyrosine and a negative regulation of the mitogenic signal
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regulation of the function of epidermal growth factor receptor in keratinocytes by its dephosphorylation
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SHP-1 may regulate the tethering of receptors to the cytoskeleton and/or the extent of cross-linking of actin filaments in platelets
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activation of SPH-1 and SPH-2 is accompanied by reduced responsiveness to aggregating agents, phosphorylation of SPH-1 and SPH-2 introduces docking sites for adaptor molecules like growth factor receptor-bound protein 2 regulating further signaling to integrin alphaIIbbeta3
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by modulating Src-focal adhesion kinase signaling at adhesion sites, PTPD1 promotes the cytoskeleton events that induce cell adhesion and migration
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functional inactivation of the protein tyrosine phosphatase DEP-1 leads to increased endothelial cell proliferation and failure of vessels to remodel and branch
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human LMW-PTP is critical in the regulation of mitogenic signalling and Rho-mediated cytoskeletal rearrangements after platelet derived growth factor stimulation
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SHP-2, MKP-1, LAR, and PTEN are targets of platelet-derived growth factor-induced reversible oxidation
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ED-Eya2 is bifunctional acting as protein tyrosine phosphatase and as transcription factor. The transcriptional activity of Eya proteins is regulated by a dephosphorylating activity within its Eya domain, structure-function analysis, overview
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ED-Eya2 is bifunctional acting as protein tyrosine phosphatase and as transcription factor. The transcriptional activity of Eya proteins is regulated by a dephosphorylating activity within its Eya domain, structure-function analysis, overview
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isozyme p52shc associates with the growth factor receptor-bound protein-2, Grb2. Overexpression of isozyme p66shc impaires IGF-I-stimulated p52shc tyrosine phosphorylation and p52shc-Grb2 association. Isozyme p66shc inhibits IGF-I signal transduction via competitively inhibiting the binding of Src homology 2 domain-containing SHP-2 to SHP substrate-1, leading to the disruption of SHPS-1/SHP-2/Src/p52shc complex formation, an event that is essential for p52shc phosphorylation and Grb2 recruitment, overview. p66shc inhibits IGF-I signal transduction via impairing membrane recruitment of Grb2
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protein tyrosine phosphatase 1B, PTP1B, is an intracellular non-receptor type PTP
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PTEN phosphoprotein phosphatase catalysis of phosphoprotein dephosphorylation follows a two-step mechanism with Cys124 transiently phosphorylated to form the phosphoenzyme intermediate
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physiological substrates, overview
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possible specific substrate is p190Rho-GAP
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the isoforms of PRP36 may function as adapter molecules rather than as a phosphatase
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protein tyrosine phosphatase alpha regulates the activity of raft Fyn
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PTP-PEST most likely also participates in regulating osteoclast differentiation and adhesion to bone matrix
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PTPalpha is required for stem cell factor-stimulated Src family kinase activation and signaling, and for mast cell migration
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SHP-1 is a negative regulator of osteoclastogenic signalling
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in vivo phagocytosis assay and in vivo microglial migration assay, overview
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in vivo phagocytosis assay and in vivo microglial migration assay, overview
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protein-tyrosine phosphatases are signaling molecules that are involved in numerous cellular mechanisms such as cell growth and proliferation, cell cycle regulation, and cytoskeletal integrity
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LAR, PTPalpha and PTP1B may act upon cell surface insulin receptors
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enzyme activity is correlated with sperm thiol status and tyrosine phosphorylation of sperm proteins during maturation is promoted by thiol oxidation and diminished enzyme
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enzyme isoform Shp2 is required for complete activation of mitogen-activated protein kinases MAPKs by brain-derived neurotropic factor
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SynPTP displays catalytic activity towards all tyrosyl-phosphorylated proteins, but fails to dephosphorylate the same serylphosphorylated substrates, SynPTP functions as a protein tyrosine phosphatase not as a dual-specific phosphatase
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essential for virulence of the bacteria responsible for the plague
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