1.8.3.7: formylglycine-generating enzyme
This is an abbreviated version!
For detailed information about formylglycine-generating enzyme, go to the full flat file.
Word Map on EC 1.8.3.7
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1.8.3.7
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sulfatases
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metachromatic
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mucopolysaccharidosis
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leukodystrophy
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ichthyosis
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antibody-drug
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ultra-rare
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morquio
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medicine
- 1.8.3.7
-
sulfatases
-
metachromatic
- mucopolysaccharidosis
- leukodystrophy
-
ichthyosis
-
antibody-drug
-
ultra-rare
- morquio
- medicine
Reaction
Synonyms
AtsB, C-alpha-formylglycine-generating enzyme 1, Calpha-formylglycine-generating enzyme, Calpha-formylglycine-generating enzyme 1, FGE, FGly-generating enzyme, formylglycine generating enzyme, sulfatase-modifying factor 1, SUMF1
ECTree
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Crystallization
Crystallization on EC 1.8.3.7 - formylglycine-generating enzyme
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in complex with bromide and iodide ions, using 20-25% (w/v) PEG 4000, 0.1 M Tris-HCl pH 8.0-9.0, 0.2-0.3 M CaCl2
vapor diffusion method, using 100 mM Tris, 2.4 M ammonium formate, 0.3% (w/v) beta-octylglucoside, 3.2% (v/v) 2-butanol, pH 8.0
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X-ray crystal structure of Cu-bound enzyme at a resolution of 2.2 A
1.04 A structure of the enzyme in complex with copper and a cysteine-containing peptide substrate (Abz-ATTPLCGPSRASILSGR)