1.5.8.4: dimethylglycine dehydrogenase
This is an abbreviated version!
For detailed information about dimethylglycine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.8.4
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1.5.8.4
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sarcosine
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fad
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flavinylated
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folate-binding
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wagner
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medicine
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diagnostics
- 1.5.8.4
- sarcosine
- fad
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flavinylated
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folate-binding
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wagner
- medicine
- diagnostics
Reaction
Synonyms
Csal_0990, DdhC, DMGDH, EC 1.5.99.2, Me2GlyDH, mMe2GlyDH, N,N-dimethylglycine oxidase, pMe2GlyDH
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Engineering
Engineering on EC 1.5.8.4 - dimethylglycine dehydrogenase
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H109R
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natural polymorphism identified in a dimethylglycine dehydrogenase-deficient patient. Mutant shows only 47% of the wild-type level of bound flavin, a 27fold decrease in specific activity and a 65fold increase in Km value
H109R
rare natural variant, mutation leads to decreased protein stability, cofactor saturation, and substrate affinity
H109R
rare natural variant, suffers from decreased protein stability, cofactor saturation, and substrate affinity and causes dimethylglycine dehydrogenase deficiency leading to increased blood and urinary dimethylglycine concentrations
H109R
the mutation causes dimethylglycine dehydrogenase deficiency leading to increased blood and urinary dimethylglycine concentrations