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1.5.8.4: dimethylglycine dehydrogenase

This is an abbreviated version!
For detailed information about dimethylglycine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.8.4

Reaction

N,N-dimethylglycine
+
5,6,7,8-tetrahydrofolate
+
electron-transfer flavoprotein
=
sarcosine
+
5,10-methylenetetrahydrofolate
+
reduced electron-transfer flavoprotein

Synonyms

Csal_0990, DdhC, DMGDH, EC 1.5.99.2, Me2GlyDH, mMe2GlyDH, N,N-dimethylglycine oxidase, pMe2GlyDH

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.8 With a flavin or flavoprotein as acceptor
                1.5.8.4 dimethylglycine dehydrogenase

Disease

Disease on EC 1.5.8.4 - dimethylglycine dehydrogenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinoma, Hepatocellular
LncRNA RP11-422N16.3 Inhibits Cell Proliferation and EMT, and Induces Apoptosis in Hepatocellular Carcinoma Cells by Sponging miR-23b-3p.
Potential diagnostic and prognostic marker dimethylglycine dehydrogenase (DMGDH) suppresses hepatocellular carcinoma metastasis in vitro and in vivo.
Rat liver dimethylglycine dehydrogenase. Flavinylation of the enzyme in hepatocytes in primary culture and characterization of a cDNA clone.
dimethylglycine dehydrogenase deficiency
Cloning of dimethylglycine dehydrogenase and a new human inborn error of metabolism, dimethylglycine dehydrogenase deficiency.
Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study.
Molecular basis of dimethylglycine dehydrogenase deficiency associated with pathogenic variant H109R.
Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant.
[DMGDH gene-related dimethylglycine dehydrogenase deficiency in a case].
Leukemia
Expression of acidosis-dependent genes in human cancer nests.
Liver Neoplasms
LncRNA RP11-422N16.3 Inhibits Cell Proliferation and EMT, and Induces Apoptosis in Hepatocellular Carcinoma Cells by Sponging miR-23b-3p.
Metabolism, Inborn Errors
Choline-related-inherited metabolic diseases-A mini review.
Neoplasm Metastasis
Potential diagnostic and prognostic marker dimethylglycine dehydrogenase (DMGDH) suppresses hepatocellular carcinoma metastasis in vitro and in vivo.
Neoplasms
Expression of acidosis-dependent genes in human cancer nests.
LncRNA RP11-422N16.3 Inhibits Cell Proliferation and EMT, and Induces Apoptosis in Hepatocellular Carcinoma Cells by Sponging miR-23b-3p.
Non-alcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis is associated with a state of betaine-insufficiency.