1.5.8.4: dimethylglycine dehydrogenase

This is an abbreviated version!
For detailed information about dimethylglycine dehydrogenase, go to the full flat file.

Reaction

Synonyms

Csal_0990, DdhC, DMGDH, EC 1.5.99.2, Me2GlyDH, mMe2GlyDH, N,N-dimethylglycine oxidase, pMe2GlyDH

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.8 With a flavin or flavoprotein as acceptor

                1.5.8.4 dimethylglycine dehydrogenase

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Results	in table
264	AA Sequence
4	Application
1	CAS Registry Number
8	Cloned(Commentary)
32	Cofactor
6	Crystallization (Commentary)
43	Disease/ Diagnostics
3	Expression
7	General Information
5	Inhibitors
12	kcat/KM [mM/s]
22	KM Value [mM]
20	Localization
5	Metals/Ions
9	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
32	Organism
5	Pathway
6	PDB ID
5	pH Optimum
4	Protein Variants
10	Purification (Commentary)
1	Reaction
4	Reaction Type
28	Reference
1	Renatured (Commentary)
27	Source Tissue
8	Specific Activity [micromol/min/mg]
2	Storage Stability
47	Substrates and Products (Substrate)
7	Subunits
15	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
18	Turnover Number [1/s]

General Information

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General Information on EC 1.5.8.4 - dimethylglycine dehydrogenase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Homo sapiens

Q9UI17

rare natural mutation H109R, causes dimethylglycine dehydrogenase deficiency leading to increased blood and urinary dimethylglycine concentrations

742499

metabolism

2 entries

physiological function

4 entries

metabolism

Homo sapiens

Q9UI17

the enzyme takes part in choline degradation, one-carbon metabolism and electron transfer to the respiratory chain

742499

metabolism

Homo sapiens

Q9UI17

the phosphorylation of Akt-308/473 is significantly suppressed when the enzyme is overexpressed

743378

physiological function

Homo sapiens

Q9UI17

dimethylglycine dehydrogenase expression suppresses metastasis through the Akt signaling pathway

743378

physiological function

Homo sapiens

Q9UI17

DMGDH suppresses migration, invasion and metastasis both in vitro and in vivo. In a DMGDH over-expressing cell line, the phosphorylation of Akt-308/473 is significantly suppressed

743378

physiological function

Homo sapiens

Q9UI17

the enzyme suppresses metastasis in hepatocellular carcinoma

743378

physiological function

Apostichopus japonicus

-

during the process of intestine regeneration, there are significant differences in metabolism between regenerative intestines at 3, 7, and 14 days post evisceration and normal intestines. Genes encoding betaine-aldehyde dehydrogenase, betaine-homocysteine S-methyltransferase 1, and dimethylglycine dehydrogenase are differentially expressed to regulate the levels of betaine and N,N-dimethylglycine during intestine regeneration

764528