1.5.8.4: dimethylglycine dehydrogenase
This is an abbreviated version!
For detailed information about dimethylglycine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.8.4
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1.5.8.4
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sarcosine
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fad
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flavinylated
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folate-binding
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wagner
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medicine
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diagnostics
- 1.5.8.4
- sarcosine
- fad
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flavinylated
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folate-binding
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wagner
- medicine
- diagnostics
Reaction
Synonyms
Csal_0990, DdhC, DMGDH, EC 1.5.99.2, Me2GlyDH, mMe2GlyDH, N,N-dimethylglycine oxidase, pMe2GlyDH
ECTree
1.5.8.4 dimethylglycine dehydrogenaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.5.8.4 - dimethylglycine dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5,10-methenyltetrahydrofolate + FADH2
5,10-methylene tetrahydrofolate + FAD
-
-
-
-
?
epsilon-N-methyl-L-lysine + acceptor + H2O
formaldehyde + L-lysine + reduced acceptor
-
-
-
?
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein
sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein
N,N-dimethylglycine + electron-transfer flavoprotein + H2O
sarcosine + formaldehyde + reduced electron-transfer flavoprotein
N,N-dimethylglycine + electron-transfer flavoprotein + H2O
sarcosine + formaldehyde + reduced electron-transfer flavoprotein + H2O2
N,N-dimethylglycine + ferricenium + H2O
sarcosine + formaldehyde + ferrocene
-
-
-
?
N,N-dimethylglycine + ferricenium hexafluorophosphate + H2O
sarcosine + formaldehyde + reduced ferricenium hexafluorophosphate
-
-
-
-
?
N,N-dimethylglycine + H2O + ferrocene
sarcosine + formaldehyde + ?
-
-
-
?
N,N-dimethylglycine + H2O + oxidized 1-methoxy-5-methylphenazinium methylsulfate
sarcosine + formaldehyde + reduced 1-methoxy-5-methylphenazinium methylsulfate
-
-
-
-
?
N,N-dimethylglycine + H2O + oxidized 2,6-dichlorophenolindophenol
sarcosine + formaldehyde + reduced 2,6-dichlorophenolindophenol
N,N-dimethylglycine + oxidized ferricenium hexafluorophosphate + H2O
sarcosine + formaldehyde + reduced ferricenium hexafluorophosphate + H2O2
-
-
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
N-methyl-L-alanine + acceptor + H2O
formaldehyde + L-alanine + reduced acceptor
-
-
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
-
-
?
sarcosine + electron-transfer flavoprotein + H2O
glycine + formaldehyde + reduced electron-transfer flavoprotein + H2O2
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein
sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein
the enzyme takes part in choline degradation, one-carbon metabolism and electron transfer to the respiratory chain
-
-
?
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein
sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein
ferrocene or 2,6-dichlorophenolindophenol are used as artificial electron acceptor
-
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
-
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
bound tetrahydrofolate interacts directly with the enzyme and serves as an acceptor for the one-carbon unit produced during the oxidative demethylation of dimethylglycine
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + acceptor + H2O
sarcosine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
N,N-dimethylglycine + electron-transfer flavoprotein + H2O
sarcosine + formaldehyde + reduced electron-transfer flavoprotein
-
-
-
?
N,N-dimethylglycine + electron-transfer flavoprotein + H2O
sarcosine + formaldehyde + reduced electron-transfer flavoprotein
-
-
-
?
N,N-dimethylglycine + electron-transfer flavoprotein + H2O
sarcosine + formaldehyde + reduced electron-transfer flavoprotein + H2O2
-
-
-
r
N,N-dimethylglycine + electron-transfer flavoprotein + H2O
sarcosine + formaldehyde + reduced electron-transfer flavoprotein + H2O2
-
-
-
r
N,N-dimethylglycine + H2O + oxidized 2,6-dichlorophenolindophenol
sarcosine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
?
N,N-dimethylglycine + H2O + oxidized 2,6-dichlorophenolindophenol
sarcosine + formaldehyde + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
during the reaction tightly bound tetrahydropteroylpentaglutamate is converted to 5,10-methylene tetrahydropteroylpentaglutamate
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
reaction of the choline degradation pathway
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
reaction of the choline degradation pathway
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
reaction of the choline degradation pathway
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
reaction of the choline degradation pathway
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
reaction of the choline degradation pathway
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
reaction of the choline degradation pathway
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
reaction of the choline degradation pathway
-
?
N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor
sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
-
tetrahydropteroylpentaglutamate is used in vivo as an acceptor of the one-carbon group generated during the reaction
-
?
sarcosine + electron-transfer flavoprotein + H2O
glycine + formaldehyde + reduced electron-transfer flavoprotein + H2O2
-
-
-
r
sarcosine + electron-transfer flavoprotein + H2O
glycine + formaldehyde + reduced electron-transfer flavoprotein + H2O2
-
-
-
r
