1.5.1.8: saccharopine dehydrogenase (NADP+, L-lysine-forming) This is an abbreviated version! For detailed information about saccharopine dehydrogenase (NADP+, L-lysine-forming), go to the full flat file .
Reaction
N6-(L-1,3-dicarboxypropyl)-L-lysine +
NADP+ +
H2O =
L-lysine +
2-oxoglutarate +
NADPH +
H+
Synonyms AasS, dehydrogenase, saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming), L-lysine-alpha-ketoglutarate reductase, LKR, LKR/SDH, LOR, LOR-SDH, lysine 2-oxoglutarate reductase, lysine 2-oxoglutarate reductase-saccharopine dehydrogenase, lysine alpha-ketoglutarate reductase, lysine ketoglutarate reductase, lysine ketoglutarate/reductase saccharopine dehydrogenase, lysine-2-oxoglutarate reductase, lysine-alpha-ketoglutarate reductase, lysine-ketoglutarate reductase, lysine-ketoglutarate reductase/saccharopine dehydrogenase, lysine-ketoglutaric reductase, lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[glutaryl-2]-L-lysine forming), nllkr/sdh, saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase, saccharopine dehydrogenase, saccharopine dehydrogenase (NADP, lysine-forming), saccharopine dehydrogenase (nicotinamide adenine dinucleotide phosphate, lysine-forming)
ECTree
Activating Compound
Activating Compound on EC 1.5.1.8 - saccharopine dehydrogenase (NADP+, L-lysine-forming)
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abscisic acid
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0.05 mM, incubation for 12 h, significantly increased activity
EDTA
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1 mM, slight activation, effect not consistant
polyethylene glycol 6000
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enzyme activity increases in response to an upshock osmotic stress caused by polyethylene glycol 6000 solutions of decreasing osmotic potential with values ranging from -0.1 to -3 MPa
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Tris/HCl
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enzyme activity increases 6fold when the concentration of Tris/HCl is increased from 25 to 200 mM, effect is due to decreased water activity which could induce conformational modification in LOR domain of enzyme
Triton X-100
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1%, slight activation, effect not consistant
L-lysine
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excess cellular lysine may stimulate activity
L-lysine
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excess lysine is a major stimulator of enzyme activity
organic solvent
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activates
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organic solvent
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e.g. poly(ethylene glycol) 8000 and ethyleneglycol increase enzyme activity, but lower increase than by 200 mM Tris/HCl buffer
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additional information
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activity is enhanced with decreasing osmotic potential and LKR/SDH gene is upregulated by osmotic stress
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additional information
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L-lysine formation is not activated by (NH4)2SO4
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additional information
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C-hordein suppression alters the enzyme activity differentially in different developmental stages, the extent varies among the transgenic lines, overview
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additional information
in immature rice endosperm, the enzymatic activity of the LKR domain is activated by Ca2+, Mg2+, high salt, and osmolytes
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additional information
A0A3L6FCN0
in immature maize endosperm, the enzymatic activity of the LKR domain is activated by Ca2+, Mg2+, high salt, and osmolytes
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