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1.5.1.8: saccharopine dehydrogenase (NADP+, L-lysine-forming)

This is an abbreviated version!
For detailed information about saccharopine dehydrogenase (NADP+, L-lysine-forming), go to the full flat file.

Word Map on EC 1.5.1.8

Reaction

N6-(L-1,3-dicarboxypropyl)-L-lysine
+
NADP+
 +
H2O
=
L-lysine
 +
2-oxoglutarate
 +
NADPH
 +
H+

Synonyms

AasS, dehydrogenase, saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming), L-lysine-alpha-ketoglutarate reductase, LKR, LKR/SDH, LOR, LOR-SDH, lysine 2-oxoglutarate reductase, lysine 2-oxoglutarate reductase-saccharopine dehydrogenase, lysine alpha-ketoglutarate reductase, lysine ketoglutarate reductase, lysine ketoglutarate/reductase saccharopine dehydrogenase, lysine-2-oxoglutarate reductase, lysine-alpha-ketoglutarate reductase, lysine-ketoglutarate reductase, lysine-ketoglutarate reductase/saccharopine dehydrogenase, lysine-ketoglutaric reductase, lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[glutaryl-2]-L-lysine forming), nllkr/sdh, saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase, saccharopine dehydrogenase, saccharopine dehydrogenase (NADP, lysine-forming), saccharopine dehydrogenase (nicotinamide adenine dinucleotide phosphate, lysine-forming)

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming)

Disease

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Disease on EC 1.5.1.8 - saccharopine dehydrogenase (NADP+, L-lysine-forming)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Cystinuria
Hyperlysinemia with saccharopinuria due to combined lysine-ketoglutarate reductase and saccharopine dehydrogenase deficiencies presenting as cystinuria.
Hyperlysinemias
Familial hyperlysinemia with lysine-ketoglutarate reductase insufficiency.
Familial hyperlysinemia: enzyme studies, diagnostic methods, comments on terminology.
Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities.
Hyperlysinemia with saccharopinuria due to combined lysine-ketoglutarate reductase and saccharopine dehydrogenase deficiencies presenting as cystinuria.
Multiple enzyme defects in familial hyperlysinemia.
The prognosis of hyperlysinemia: an interim report.
Infections
Proteomic analysis of fungal host factors differentially expressed by Fusarium graminearum infected with Fusarium graminearum virus-DK21.
saccharopine dehydrogenase (nadp+, l-lysine-forming) deficiency
Hyperlysinemia with saccharopinuria due to combined lysine-ketoglutarate reductase and saccharopine dehydrogenase deficiencies presenting as cystinuria.
Multiple enzyme defects in familial hyperlysinemia.
The prognosis of hyperlysinemia: an interim report.
Starvation
General and lysin specific control of saccharopine dehydrogenase levels in the yeast Saccharomycopsis lipolytica.
LKR/SDH plays important roles throughout the tick life cycle including a long starvation period.
Regulation of lysine catabolism in Arabidopsis through concertedly regulated synthesis of the two distinct gene products of the composite AtLKR/SDH locus.
Synthesis of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is concertedly regulated by metabolic and stress-associated signals.