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Information on EC 1.5.1.8 - saccharopine dehydrogenase (NADP+, L-lysine-forming)
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EC Tree
1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming)Specify your search results
Word Map
- 1.5.1.8
- alpha-aminoadipate
- hyperlysinemia
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pipecolic
- dihydrodipicolinate
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aminoadipic
- homocitrate
- medicine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
saccharopine dehydrogenase, lkr/sdh, lysine-ketoglutarate reductase, lysine-ketoglutarate reductase/saccharopine dehydrogenase, lysine alpha-ketoglutarate reductase, lysine-alpha-ketoglutarate reductase, lysine ketoglutarate reductase, lysine 2-oxoglutarate reductase, nllkr/sdh, l-lysine-alpha-ketoglutarate reductase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming)
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L-lysine-alpha-ketoglutarate reductase
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LKR
LKR/SDH
LOR
lysine 2-oxoglutarate reductase-saccharopine dehydrogenase
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bifunctional enzyme
lysine alpha-ketoglutarate reductase
lysine ketoglutarate reductase
lysine-2-oxoglutarate reductase
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lysine-alpha-ketoglutarate reductase
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lysine-ketoglutarate reductase
lysine-ketoglutarate reductase/saccharopine dehydrogenase
lysine-ketoglutaric reductase
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lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[glutaryl-2]-L-lysine forming)
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saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase
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saccharopine dehydrogenase
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saccharopine dehydrogenase (NADP, lysine-forming)
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saccharopine dehydrogenase (nicotinamide adenine dinucleotide phosphate, lysine-forming)
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LKR
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LOR
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lysine-ketoglutarate reductase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+
reaction mechanism
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N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+
ordered sequence mechanism, where 2-oxoglutarate is first substrate and saccharopine is last product
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N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+
ordered sequence mechanism, where 2-oxoglutarate is first substrate and saccharopine is last product
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N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)
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CAS REGISTRY NUMBER
COMMENTARY
9031-19-0
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DL-delta-hydroxylysine + 2-oxoglutarate + NADPH
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18% of velocity with equimolar concentration of L-lysine
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?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
L-lysine + 2-oxoglutarate + NADH + H+
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r
L-Lys + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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?
L-Lys + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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?
L-Lys + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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?
L-lysine + 2-oxoglutarate + NADH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
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?
L-lysine + 2-oxoglutarate + NADH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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unidirectional lysine catabolic activity
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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uni-directional activity plays an important role in regulating the catabolic function of alpha-aminoadipidic acid pathway in plants and stems from structure rather than its linkage to saccharopine dehydrogenase EC 1.5.1.9
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ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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first enzyme in lysine catabolism
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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lysine catabolism
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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lysine catabolism
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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lysine catabolism
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ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
epsilon-N-(L-glutaryl-2)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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major catabolic pathway of lysine in mammalian livers
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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lysine catabolism
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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L-lysine catabolism is reversibly osmo-regulated at the level of LKR/SDH bifunctional enzyme
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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first and possibly a rate-limiting step in lysine catabolism
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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first and major regulatory step in lysine catabolism, lysine may auto-regulate its own catabolism in vivo, plant seeds: active enzyme is a phosphoprotein, its activity is modulated by opposing actions of protein kinases and phosphatases
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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reverse reaction not detected
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?, ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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reverse reaction not detected
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
epsilon-N-(L-glutaryl-2)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
epsilon-N-(L-glutaryl-2)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
epsilon-N-(L-glutaryl-2)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
ir
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
saccharopine pathway is the major route of lysine breakdown
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
important role in the degradation of lysine
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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enzyme catalyzes lysine synthesis from saccharopine, reverse direction is favoured
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
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biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is stimulated in vivo upon treatment with protein phosphatase inhibitor
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme activity is modulated in vivo by a lysine-dependent intracellular signaling cascade, mediated by Ca2+ and protein phosphorylation/dephosphorylation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
regulation of lysine catabolism may be essential for lysine accumulation in rice plants
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
regulation of lysine catabolism may be essential for lysine accumulation in rice plants
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
lysine formation is only 3-5% of the saccharopine formation, N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
equilibrium favors sacharopine formation, lysine formation is only 3-5% of the saccharopine formation
lysine formation is only 3-5% of the saccharopine formation, N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
lysine formation is only 3-5% of the saccharopine formation
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
saccharopine pathway is the major route of lysine breakdown
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
initial enzyme of saccharopine-dependent lysine degradation, lysine transport into the mitochondrion may control lysine degradation
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH
lysine formation is only 3-5% of the saccharopine formation, N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine synthesis from saccharopine, reverse direction is favoured
NAD+ as electron acceptor for L-lysine formation
?, r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine synthesis from saccharopine, reverse direction is favoured
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine synthesis from saccharopine, reverse direction is favoured
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?, r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
biosynthetic pathway of lysine in yeast and fungi
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
increase in free lysine concentration in cells decrease enzyme activity through repression of lys1 gene, precursor alpha-aminoadipic-delta-semialdehyde modulates a transcriptional factor that controls transcription of lys1 gene
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
plays essential role in lysine biosynthesis, LKR and SDH are separate polypeptides
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine anabolic function is regulated by complex transcriptional and post-transcriptional controls
-
r
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
saccharopine is a key intermediate in the degradative pathway of lysine metabolism
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
specific for L-lysine, 2-oxoglutarate and NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
specific for L-lysine, 2-oxoglutarate and NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
enzyme catalyzes lysine degradation to saccharopine
N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
activity of native enzyme is inhibited after modulation, enzyme undergoes a conformational alteration to expose the catalytic domain for substrate binding, Ca2+ may be the most important physiological modulator of enzyme activity, it possibly activates through the derepression of an inhibitory domain in vivo
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
first step in lysine breakdown in the endosperm during seed development
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
lysine catabolism
-
?
L-lysine + 2-oxoglutarate + NADPH
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
the enzyme is involved in lysine degradation
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
?
L-lysine + 2-oxoglutarate + NADPH + H+
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
-
-
-
?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
reaction of the LKR domain
-
-
r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
L-lysine + 2-oxoglutarate + NADPH + H+
A0A3L6FCN0
reaction of the LKR domain
-
-
r
S-2-aminoethyl-L-cysteine + 2-oxoglutarate + NADPH
?
-
47% of velocity with equimolar concentration of L-lysine
-
-
?
S-2-aminoethyl-L-cysteine + 2-oxoglutarate + NADPH
?
-
52% of activity with equimolar concentration of L-lysine, same Vmax, but higher Km-value than for L-lysine
-
-
?
S-2-aminoethyl-L-cysteine + 2-oxoglutarate + NADPH
?
-
52% of activity with equimolar concentration of L-lysine, same Vmax, but higher Km-value than for L-lysine
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) comprises a LKR domain, which condenses lysine and 2-oxoglutarate into saccharopine, and the SDH domain, that hydrolyzes saccharopine to form glutamate and alpha-aminoadipate semialdehyde, the latter of which is oxidized to alpha-aminoadipate by aminoadipate semialdehyde dehydrogenase (AASADH)
-
-
-
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) comprises a LKR domain, which condenses lysine and 2-oxoglutarate into saccharopine, and the SDH domain, that hydrolyzes saccharopine to form glutamate and alpha-aminoadipate semialdehyde, the latter of which is oxidized to alpha-aminoadipate by aminoadipate semialdehyde dehydrogenase (AASADH)
-
-
-
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
less than 2% of the rate of L-lysine: D-lysine, cadaverine, delta-aminovaleric acid, alpha-acetyl-L-lysine, alpha-amino-epsilon-hydroxycaproic acid, L-lysylglycine, L-2,4-diaminobutyric acid, DL-pipecolic acid, L-ornithine, epsilon-aminocaproic acid, 4% of the rate of L-lysine: DL-alpha,epsilon-diaminopimelic acid, 7% of the rate of 2-oxoglutarate: oxaloacetic acid, less than 2% of the rate of 2-oxoglutarate: 2-oxoadipate, pyruvate, 2-oxoisocaproate, 2-oxoisovalerate, levulinate, 2-hydroxyglutarate
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) comprises a LKR domain, which condenses lysine and 2-oxoglutarate into saccharopine, and the SDH domain, that hydrolyzes saccharopine to form glutamate and alpha-aminoadipate semialdehyde, the latter of which is oxidized to alpha-aminoadipate by aminoadipate semialdehyde dehydrogenase (AASADH)
-
-
-
additional information
?
-
the enzyme is bifunctional catalyzing the reaction of EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming) in the reverse direction, and EC 1.5.1.9, saccharopine dehydrogenase (NAD+, L-glutamate-forming)
-
-
?
additional information
?
-
-
the enzyme is bifunctional catalyzing the reaction of EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming) in the reverse direction, and EC 1.5.1.9, saccharopine dehydrogenase (NAD+, L-glutamate-forming)
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
the bifunctional enzyme lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) comprises a LKR domain, which condenses lysine and 2-oxoglutarate into saccharopine, and the SDH domain, that hydrolyzes saccharopine to form glutamate and alpha-aminoadipate semialdehyde, the latter of which is oxidized to alpha-aminoadipate by aminoadipate semialdehyde dehydrogenase (AASADH)
-
-
-
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
bifunctional enzyme with lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 activities
-
-
?
additional information
?
-
-
lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 are separate enzymes
-
-
?
additional information
?
-
-
not as substrates: ornithine, glutamine, oxaloacetate, pyruvate
-
-
?
additional information
?
-
-
not as electron acceptor: NADH
-
-
?
additional information
?
-
-
lysine-oxoglutarate reductase EC 1.5.1.8 and saccharopine dehydrogenase EC 1.5.1.9 are separate enzymes
-
-
?
additional information
?
-
-
not as substrates: ornithine, glutamine, oxaloacetate, pyruvate
-
-
?
additional information
?