1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase

This is an abbreviated version!
For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.29

Reaction

(25R)-cholest-5-ene-3beta,26-diol
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
(25R)-cholest-5-ene-3beta,7alpha,26-triol
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase

Expression

Expression on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression of CYP7B1 by estrogen receptor can be mediated via the PI3K/Akt signal pathway. Overexpression of PI3K or Akt significantly increases estrogenic up-regulation of CYP7B1
-
expression of CYP7B1 by estrogen receptor can be mediated via the PI3K/Akt signal pathway. Treatment with LY294002, a specific inhibitor of phosphatidylinositol 3-kinase PI3K, abolishes estrogen-receptor-mediated up-regulation of a CYP7B1 promoter-luciferase reporter
-
lipopolysaccharide treatment does not increase the expression
-