1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase

This is an abbreviated version!
For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.29

Reaction

(25R)-cholest-5-ene-3beta,26-diol
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
(25R)-cholest-5-ene-3beta,7alpha,26-triol
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase

Systematic Name

Systematic Name on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

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SYSTEMATIC NAME
IUBMB Comments
cholest-5-ene-3beta,25/26-diol,[NADPH-hemoprotein reductase]:oxygen oxidoreductase (7alpha-hydroxylating)
A P-450 (heme-thiolate) protein. Unlike EC 1.14.14.26, 24-hydroxycholesterol 7alpha-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent [2]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.