1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase

This is an abbreviated version!
For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.29

Reaction

(25R)-cholest-5-ene-3beta,26-diol
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
(25R)-cholest-5-ene-3beta,7alpha,26-triol
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase

Source Tissue

Source Tissue on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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bone marrow-derived
Manually annotated by BRENDA team
-
CYP7B1 is overexpressed in high-grade prostatic intraepithelial neoplasia and in prostate cancer
Manually annotated by BRENDA team
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CYP7B1 is overexpressed in high-grade prostatic intraepithelial neoplasia and in prostate cancer
Manually annotated by BRENDA team
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CYP7B1 is overexpressed in high-grade prostatic intraepithelial neoplasia and in prostate cancer
Manually annotated by BRENDA team
-
activity is detected in keratinocytes of the spinous and granula layers, and to lesser extent in the basal layer and basal cell bodies. High activity in hair follicle associated cells
Manually annotated by BRENDA team
-
CYP7B1 occurrs in trabecular stroma cells
Manually annotated by BRENDA team
additional information
-
CYP7B1 is elevated by 1.5 days postpartum compared with other ages, levels decrease in the midneonatal period and then increase by 20.5 days postpartum
Manually annotated by BRENDA team