1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase

This is an abbreviated version!
For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Word Map on EC 1.14.14.29

Reaction

(25R)-cholest-5-ene-3beta,26-diol
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
(25R)-cholest-5-ene-3beta,7alpha,26-triol
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase

Reference

Reference on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schwarz, M.; Lund, E.G.; Lathe, R.; Björkhem, I.; Russell, D.W.
Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA
J. Biol. Chem.
272
23995-24001
1997
Mus musculus
Manually annotated by BRENDA team
Russell, D.W.
The enzymes, regulation, and genetics of bile acid synthesis
Annu. Rev. Biochem.
72
137-174
2003
Homo sapiens (O75881), Mus musculus (Q60991)
Manually annotated by BRENDA team
Martin, C.; Bean, R.; Rose, K.; Habib, F.; Seckl, J.
cyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostate
Biochem. J.
355
509-515
2001
Rattus norvegicus
Manually annotated by BRENDA team
Toll, A.; Wikvall, K.; Sudjana-Sugiaman, E.; Kondo, K.H.; Björhem, I.
7alpha-Hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7alpha-hydoxylase
Eur. J. Biochem.
224
309-316
1994
Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Wu, Z.; Chiang, J.Y.
Transcriptional regulation of human oxysterol 7alpha-hydroxylase gene (CYP7B1) by Sp1
Gene
272
191-197
2001
Homo sapiens
Manually annotated by BRENDA team
Pandak William, M.; Hylemon Phillip, B.; Ren, S.; Marques, D.; Gil, G.; Redford, K.; Mallonee, D.; Vlahcevic, Z.R.
Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes
Hepatology
35
1400-1408
2002
Rattus norvegicus
Manually annotated by BRENDA team
Li-Hawkins, J.; Lund, E.G.; Turley, S.D.; Russell, D.W.
Disruption of the oxysterol 7alpha-hydroxylase gene in mice
J. Biol. Chem.
275
16536-16542
2000
Mus musculus
Manually annotated by BRENDA team
Li-Hawkins, J.; Lund, E.G.; Bronson, A.D.; Russell, D.W.
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol
J. Biol. Chem.
275
16543-16549
2000
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Wu, Z.; Martin, K.O.; Javitt, N.B.; Chiang, J.Y.
Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
J. Lipid Res.
40
2195-2203
1999
Homo sapiens
Manually annotated by BRENDA team
Ren, S.; Marques, D.; Redford, K.; Hylemon, P.B.; Gil, G.; Vlahcevic, Z.R.; Pandak, W.M.
Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat
Metabolism
52
636-642
2003
Rattus norvegicus
Manually annotated by BRENDA team
Tsaousidou, M.K.; Ouahchi, K.; Warner, T.T.; Yang, Y.; Simpson, M.A.; Laing, N.G.; Wilkinson, P.A.; Madrid, R.E.; Patel, H.; Hentati, F.; Patton, M.A.; Hentati, A.; Lamont, P.J.; Siddique, T.; Crosby, A.H.
Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degeneration
Am. J. Hum. Genet.
82
510-515
2008
Homo sapiens
Manually annotated by BRENDA team
Pettersson, H.; Holmberg, L.; Axelson, M.; Norlin, M.
CYP7B1-mediated metabolism of dehydroepiandrosterone and alpha-androstane-3beta,17beta-diol - potential role(s) for estrogen signaling
FEBS J.
275
1778-1789
2008
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Hennebert, O.; Chalbot, S.; Alran, S.; Morfin, R.
Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes
J. Steroid Biochem. Mol. Biol.
104
326-333
2007
Homo sapiens
Manually annotated by BRENDA team
Wada, T.; Kang, H.S.; Angers, M.; Gong, H.; Bhatia, S.; Khadem, S.; Ren, S.; Ellis, E.; Strom, S.C.; Jetten, A.M.; Xie, W.
Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)
Mol. Pharmacol.
73
891-899
2008
Mus musculus
Manually annotated by BRENDA team
Olsson, M.; Gustafsson, O.; Skogastierna, C.; Tolf, A.; Rietz, B.D.; Morfin, R.; Rane, A.; Ekstroem, L.
Regulation and expression of human CYP7B1 in prostate: overexpression of CYP7B1 during progression of prostatic adenocarcinoma
Prostate
67
1439-1446
2007
Homo sapiens
Manually annotated by BRENDA team
Burke, K.T.; Horn, P.S.; Tso, P.; Heubi, J.E.; Woollett, L.A.
Hepatic bile acid metabolism in the neonatal hamster: expansion of the bile acid pool parallels increased Cyp7a1 expression levels
Am. J. Physiol. Gastrointest. Liver Physiol.
297
G144-G151
2009
Mesocricetus auratus
Manually annotated by BRENDA team
Diczfalusy, U.; Olofsson, K.; Carlsson, A.; Gong, M.; Golenbock, D.; Rooyackers, O.; Fläring, U.; Björkbacka, H.
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
J. Lipid Res.
50
2258-2264
2009
Mus musculus
Manually annotated by BRENDA team
Pettersson, H.; Lundqvist, J.; Oliw, E.; Norlin, M.
CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): A novel pathway for potential regulation of the cellular levels of androgens and neurosteroids
Biochim. Biophys. Acta
1791
1206-1215
2009
Homo sapiens, Homo sapiens (O75881), Mus musculus (Q60991), Sus scrofa
Manually annotated by BRENDA team
Zhou, C.; King, N.; Chen, K.Y.; Breslow, J.L.
Activation of pregnane X receptor induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apolipoprotein E deficient mice
J. Lipid Res.
50
2004-2010
2009
Mus musculus
Manually annotated by BRENDA team
Tang, W.; Pettersson, H.; Norlin, M.
Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling
J. Steroid Biochem. Mol. Biol.
112
63-73
2008
Homo sapiens
Manually annotated by BRENDA team
Arnoldi, A.; Crimella, C.; Tenderini, E.; Martinuzzi, A.; D'Angelo, M.G.; Musumeci, O.; Toscano, A.; Scarlato, M.; Fantin, M.; Bresolin, N.; Bassi, M.T.
Clinical phenotype variability in patients with hereditary spastic paraplegia type 5 associated with CYP7B1 mutations
Clin. Genet.
81
150-157
2012
Homo sapiens, Homo sapiens (O75881)
Manually annotated by BRENDA team
Roos, P.; Svenstrup, K.; Danielsen, E.R.; Thomsen, C.; Nielsen, J.E.
CYP7B1: novel mutations and magnetic resonance spectroscopy abnormalities in hereditary spastic paraplegia type 5A
Acta Neurol. Scand.
129
330-334
2013
Homo sapiens
Manually annotated by BRENDA team
Siam, A.; Brancale, A.; Simons, C.
Comparative modeling of 25-hydroxycholesterol-7alpha-hydroxylase (CYP7B1): ligand binding and analysis of hereditary spastic paraplegia type 5 CYP7B1 mutations
J. Mol. Model.
18
441-453
2012
Homo sapiens, Homo sapiens (O75881)
Manually annotated by BRENDA team