1.14.13.231: tetracycline 11a-monooxygenase

This is an abbreviated version!
For detailed information about tetracycline 11a-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.231

Reaction

RH
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
ROH
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

BN1088_100004, tetracycline resistance protein from transposon Tn4351/Tn4400, tetracylcine resistance protein TetX, TetX, TetX family tetracycline inactivation enzyme, TetX2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.231 tetracycline 11a-monooxygenase

Reference

Reference on EC 1.14.13.231 - tetracycline 11a-monooxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yang, W.; Moore, I.F.; Koteva, K.P.; Bareich, D.C.; Hughes, D.W.; Wright, G.D.
TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics
J. Biol. Chem.
279
52346-52352
2004
Bacteroides fragilis, Bacteroides thetaiotaomicron (Q93L51)
Manually annotated by BRENDA team
Moore, I.F.; Hughes, D.W.; Wright, G.D.
Tigecycline is modified by the flavin-dependent monooxygenase TetX
Biochemistry
44
11829-11835
2005
Bacteroides fragilis
Manually annotated by BRENDA team
Volkers, G.; Damas, J.M.; Palm, G.J.; Panjikar, S.; Soares, C.M.; Hinrichs, W.
Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX
Acta Crystallogr. Sect. D
69
1758-1767
2013
Bacteroides thetaiotaomicron (Q93L51)
Manually annotated by BRENDA team
Yu, Z.; Reichheld, S.E.; Cuthbertson, L.; Nodwell, J.R.; Davidson, A.R.
Characterization of tetracycline modifying enzymes using a sensitive in vivo reporter system
BMC Biochem.
11
34
2010
Bacteroides fragilis
Manually annotated by BRENDA team
Volkers, G.; Palm, G.J.; Weiss, M.S.; Wright, G.D.; Hinrichs, W.
Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase
FEBS Lett.
585
1061-1066
2011
Bacteroides thetaiotaomicron (Q93L51)
Manually annotated by BRENDA team
Ghosh, S.; LaPara, T.M.; Sadowsky, M.J.
Transformation of tetracycline by TetX and its subsequent degradation in a heterologous host
FEMS Microbiol. Ecol.
91
fiv059
2015
Sphingobacterium sp. (A0A077XNF8), Sphingobacterium sp. PM2-P1-29 (A0A077XNF8)
Manually annotated by BRENDA team
Speer, B.S.; Bedzyk, L.; Salyers, A.A.
Evidence that a novel tetracycline resistance gene found on two Bacteroides transposons encodes an NADP-requiring oxidoreductase
J. Bacteriol.
173
176-183
1991
Bacteroides fragilis (Q01911)
Manually annotated by BRENDA team
Garcia-Echauri, S.A.; Cardineau, G.A.
TETX: a novel nuclear selection marker for Chlamydomonas reinhardtii transformation
Plant Methods
11
27
2015
Enterobacteriaceae bacterium (I6YQD0), Enterobacteriaceae bacterium SL1 (I6YQD0)
Manually annotated by BRENDA team
Walkiewicz, K.; Davlieva, M.; Wu, G.; Shamoo, Y.
Crystal structure of Bacteroides thetaiotaomicron TetX2: A tetracycline degrading monooxygenase at 2.8 Ã… resolution
Proteins
79
2335-2340
2011
Bacteroides thetaiotaomicron (Q93L51), Bacteroides thetaiotaomicron
Manually annotated by BRENDA team