1.14.13.231: tetracycline 11a-monooxygenase
This is an abbreviated version!
For detailed information about tetracycline 11a-monooxygenase, go to the full flat file.
Word Map on EC 1.14.13.231
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1.14.13.231
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electrocatalytic
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bacteroides
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greenhouse
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electrochemical
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enzyme-based
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polyethyleneimine
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glassy
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biosensing
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electrode
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biosensors
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thetaiotaomicron
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dissipation
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metagenomic
-
degradation
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biotechnology
-
analysis
- 1.14.13.231
-
electrocatalytic
-
bacteroides
-
greenhouse
-
electrochemical
-
enzyme-based
-
polyethyleneimine
-
glassy
-
biosensing
-
electrode
-
biosensors
- thetaiotaomicron
-
dissipation
-
metagenomic
- degradation
- biotechnology
- analysis
Reaction
Synonyms
BN1088_100004, tetracycline resistance protein from transposon Tn4351/Tn4400, tetracylcine resistance protein TetX, TetX, TetX family tetracycline inactivation enzyme, TetX2
ECTree
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General Information
General Information on EC 1.14.13.231 - tetracycline 11a-monooxygenase
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physiological function
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tigecycline is a substrate for TetX and bacterial strains containing the TetX gene are resistant to tigecycline due to the modification of tigecycline by TetX to form 11a-hydroxytigecycline, which has a weakened ability to inhibit protein translation compared with tigecycline. 11a-Hydroxytigecycline forms a weaker complex with magnesium than tigecycline, magnesium coordination is critical for binding tetracycline to the ribosome