1.14.13.231: tetracycline 11a-monooxygenase

This is an abbreviated version!
For detailed information about tetracycline 11a-monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.231

Reaction

RH
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
ROH
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

BN1088_100004, tetracycline resistance protein from transposon Tn4351/Tn4400, tetracylcine resistance protein TetX, TetX, TetX family tetracycline inactivation enzyme, TetX2

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.231 tetracycline 11a-monooxygenase

KM Value

KM Value on EC 1.14.13.231 - tetracycline 11a-monooxygenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.076
alpha-doxycycline
pH 8.5, temperature not specified in the publication
0.13 - 0.16
anhydrotetracycline
0.11
chlorotetracycline
-
presence of 0.0002% arabinose, pH not specified in the publication, temperature not specified in the publication
0.11
chlortetracycline
0.0199 - 0.02
demeclocycline
0.083 - 0.084
doxycycline
0.028 - 0.0284
minocycline
0.133
NADPH
0.076
oxytetracycline
-
pH 8.5
0.054
tetracycline
0.044
tigecycline
-
pH 8.5, temperature not specified in the publication