1.14.11.66: [histone H3]-trimethyl-L-lysine9 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine9 demethylase, go to the full flat file.

Reaction

Synonyms

5qNCA, AN1060, BHC110, CG15835, CG33182, Dmel\Kdm4A, GASC1, H3K9 demethylase, H3K9 trimethyl demethylase, H3K9-specific demethylase, H3K9/36me3 lysine demethylase, H3K9me2/3 demethylase, H3K9Me3 demethylase, H3K9me3 histone demethylase, H3K9me3-specific demethylase, histone demethylase, histone demethylase JmjD2A, histone demethylase JMJD2A/KDM4A, histone demethylase JMJD2B, histone H3 demethylase, histone H3 Lys 9 demethylase, histone H3K9 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, histone-3 lysine-9 di-/tri-methyl demethylase, JDHM3A, JHDM2A, JHDM2B, JHDM3A, JmjC histone lysine demethylase, JmjC-domain-containing histone demethylase 3A, JMJD1A, JMJD1B, JMJD2, JMJD2(1), JMJD2(2), JMJD2A, JMJD2A demethylase, JMJD2A/KDM4A, JMJD2B, JMJD2b histone demethylase, JMJD2C, JMJD2D, jumonji C-domaincontaining histone demethylase 3A, jumonji domain containing 2A, Jumonji domaincontaining demethylase, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM1, KDM2B, Kdm3a, Kdm3b, KDM4, KDM4A, KDM4A lysine demethylase, KDM4A/JMJD2A, KDM4B, KDM4B/JMJD2B histone demethylase, Kdm4c, KDM4D, KDM4E, KdmA, KIAA0601, LD33386, LSD1, LSD1 demethylase, LSD1 H3 demethylase, lysine-specific demethylase 1, lysine-specific demethylase 4A, lysine-specific demethylase 4B, lysine-specific demethylase 4C, lysine-specific demethylase 4D, More, testis-enriched histone demethylase, tridemethylase of H3K9, trimethylated histone H3-lysine 9-specific demethylase, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM, [histone H3]-lysine-9 demethylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.66 [histone H3]-trimethyl-L-lysine9 demethylase

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Results	in table
8	Activating Compound
4071	AA Sequence
13	Application
51	Cloned(Commentary)
3	Cofactor
9	Crystallization (Commentary)
3428	Disease/ Diagnostics
15	Expression
142	General Information
1	General Stability
40	IC50 Value
119	Inhibitors
24	kcat/KM [mM/s]
33	KM Value [mM]
42	Localization
19	Metals/Ions
146	Natural Substrates/ Products (Substrates)
92	Organism
6	PDB ID
8	pH Optimum
53	Protein Variants
16	Purification (Commentary)
3	Reaction
74	Reference
109	Source Tissue
28	Specific Activity [micromol/min/mg]
214	Substrates and Products (Substrate)
2	Subunits
275	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
24	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.14.11.66 - [histone H3]-trimethyl-L-lysine9 demethylase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.079

(R)-2-hydroxyglutarate

Homo sapiens

-

pH and temperature not specified in the publication

756531

0.097

(S)-2-hydroxyglutarate

Homo sapiens

-

pH and temperature not specified in the publication

756531

0.037

2-(2-((chroman-6-ylmethyl)amino)pyrimidin-4-yl)isonicotinic acid

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.003

3-(9-(dimethylamino)-N-hydroxynonanamido)propanoic acid

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.2

3-[hydroxy-[5-[[(1R)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-5-oxo-pentanoyl]amino]propanoic acid

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0703

3-[hydroxy-[5-[[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-5-oxo-pentanoyl]amino]propanoic acid

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0606

3-[hydroxy-[7-[[(1S)-2-methoxy-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-7-oxo-heptanoyl]amino]propanoic acid

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0068

3-[hydroxy-[8-[[(1R)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoic acid

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0136

3-[hydroxy-[8-[[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoic acid

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0371

3-[hydroxy-[8-[[(1S)-2-methoxy-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoic acid

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0021

5-(anilinomethyl)quinolin-8-ol

Homo sapiens

-

pH and temperature not specified in the publication

756531

0.0466

5-tetrazolyl acetohydrazide

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0085

8-(hydroxyamino)-N-[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]-8-oxo-octanamide

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0137

caffeic acid

Homo sapiens

-

pH and temperature not specified in the publication

756531

0.147

dimethyl 4-hydroxy-1H-pyrazole-3,5-dicarboxylate

Homo sapiens

-

pH and temperature not specified in the publication

756531

0.0258

methyl (2S)-2-[[4-[3-(hydroxyamino)-3-oxo-propyl]benzoyl]amino]-3-(4-phenylphenyl)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0706

methyl (2S)-2-[[7-(hydroxyamino)-7-oxo-heptanoyl]amino]-3-(4-phenylphenyl)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.056

methyl (2S)-2-[[7-[hydroxy-(3-methoxy-3-oxo-propyl)amino]-7-oxo-heptanoyl]amino]-3-(4-phenylphenyl)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0171

methyl (2S)-2-[[8-[hydroxy-(3-methoxy-3-oxo-propyl)amino]-8-oxo-octanoyl]amino]-3-(4-phenylphenyl)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0563

methyl (S)-3-(2'-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0476

methyl (S)-3-(3'-cyano-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.029

methyl (S)-3-(3'-fluoro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0483

methyl (S)-3-(4'-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0548

methyl (S)-3-(4'-cyano-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0522

methyl (S)-3-(4'-fluoro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0939

methyl (S)-3-(6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0254

methyl (S)-3-([1,1'-biphenyl]-4-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0276

methyl 3-(3'-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)-2-(8-(hydroxyamino)-8-oxooctanamido)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0068

methyl 3-[hydroxy-[8-[[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]amino]-8-oxo-octanoyl]amino]propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0034

methylstat

Homo sapiens

-

pH and temperature not specified in the publication

756531

0.5

N-oxalylglycine

Homo sapiens

-

pH and temperature not specified in the publication

756531

0.2

N-[(1S)-2-(hydroxyamino)-2-oxo-1-[(4-phenylphenyl)methyl]ethyl]heptanamide

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0145

N1-((3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)-N8-hydroxyoctanediamide

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0188

N1-(2-(3'-chloro-6-hydroxy-[1,1'-biphenyl]-3-yl)ethyl)-N8-hydroxyoctanediamide

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0166

N1-(2-(3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl)ethyl)-N8-hydroxyoctanediamide

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.001

NCDM-32

Homo sapiens

-

pH and temperature not specified in the publication

756531

0.0254

SW55

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0143

tert-butyl (2S)-2-[[8-(hydroxyamino)-8-oxo-octanoyl]amino]-3-(4-phenylphenyl)propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.201

tert-butyl (2S)-2-[[8-(hydroxyamino)-8-oxo-octanoyl]amino]-3-phenyl-propanoate

Homo sapiens

O75164

pH 7.5, 37°C, recombinant enzyme

744722

0.0302

tert-butyl benzo[b]tellurophen-2-ylmethylcarbamate

Homo sapiens

O75164

37°C, pH not specified in the publication

764902

-