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Information on EC 1.14.11.66 - [histone H3]-trimethyl-L-lysine9 demethylase

for references in articles please use BRENDA:EC1.14.11.66

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IUBMB Comments

Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the tri- and di-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. cf. EC 1.14.11.65, [histone H3]-dimethyl-L-lysine9 demethylase.

The enzyme appears in viruses and cellular organisms

Synonyms
histone demethylase, kdm3a, jmjd1a, lysine-specific demethylase 1, jmjd2b, jmjd2c, histone lysine demethylase, jmjd2d, kdm3b, jhdm2a, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
overall reaction
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a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
(1a)
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a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
show the reaction diagram
(1b)
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