1.14.11.66: [histone H3]-trimethyl-L-lysine9 demethylase

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For detailed information about [histone H3]-trimethyl-L-lysine9 demethylase, go to the full flat file.

Word Map on EC 1.14.11.66

1.14.11.66

chromatin

demethylation

demethylases

trimethylation

metastasis

tumorigenesis

prostate

leukemia

methyltransferases

pluripotent

corepressors

heterochromatin

nucleosome

hypoxia-inducible

self-renewal

mesenchymal

tranylcypromine

polycomb

h3k4me2

androgen

myeloid

chromatin-modifying

histone-modifying

chip-seq

lys4

corest

flavin-dependent

hdacs

monoamine

epigenome

deacetylases

medicine

suv39h1

analysis

chip-qpcr

tudor

prc1

biotechnology

osterix

pargyline

hp1

homeodomain

fad-dependent

nanog

non-histone

pharmacology

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine9

+ 2 2-oxoglutarate + 2 O2 =

+ 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

5qNCA, AN1060, BHC110, CG15835, CG33182, Dmel\Kdm4A, GASC1, H3K9 demethylase, H3K9 trimethyl demethylase, H3K9-specific demethylase, H3K9/36me3 lysine demethylase, H3K9me2/3 demethylase, H3K9Me3 demethylase, H3K9me3 histone demethylase, H3K9me3-specific demethylase, histone demethylase, histone demethylase JmjD2A, histone demethylase JMJD2A/KDM4A, histone demethylase JMJD2B, histone H3 demethylase, histone H3 Lys 9 demethylase, histone H3K9 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, histone-3 lysine-9 di-/tri-methyl demethylase, JDHM3A, JHDM2A, JHDM2B, JHDM3A, JmjC histone lysine demethylase, JmjC-domain-containing histone demethylase 3A, JMJD1A, JMJD1B, JMJD2, JMJD2(1), JMJD2(2), JMJD2A, JMJD2A demethylase, JMJD2A/KDM4A, JMJD2B, JMJD2b histone demethylase, JMJD2C, JMJD2D, jumonji C-domaincontaining histone demethylase 3A, jumonji domain containing 2A, Jumonji domaincontaining demethylase, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM1, KDM2B, Kdm3a, Kdm3b, KDM4, KDM4A, KDM4A lysine demethylase, KDM4A/JMJD2A, KDM4B, KDM4B/JMJD2B histone demethylase, Kdm4c, KDM4D, KDM4E, KdmA, KIAA0601, LD33386, LSD1, LSD1 demethylase, LSD1 H3 demethylase, lysine-specific demethylase 1, lysine-specific demethylase 4A, lysine-specific demethylase 4B, lysine-specific demethylase 4C, lysine-specific demethylase 4D, More, testis-enriched histone demethylase, tridemethylase of H3K9, trimethylated histone H3-lysine 9-specific demethylase, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM, [histone H3]-lysine-9 demethylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.66 [histone H3]-trimethyl-L-lysine9 demethylase

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Results	in table
8	Activating Compound
4071	AA Sequence
13	Application
51	Cloned(Commentary)
3	Cofactor
9	Crystallization (Commentary)
3428	Disease/ Diagnostics
15	Expression
142	General Information
1	General Stability
40	IC50 Value
119	Inhibitors
24	kcat/KM [mM/s]
33	KM Value [mM]
42	Localization
19	Metals/Ions
146	Natural Substrates/ Products (Substrates)
92	Organism
6	PDB ID
8	pH Optimum
53	Protein Variants
16	Purification (Commentary)
3	Reaction
74	Reference
109	Source Tissue
28	Specific Activity [micromol/min/mg]
214	Substrates and Products (Substrate)
2	Subunits
275	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
24	Turnover Number [1/s]

Purification

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Purification on EC 1.14.11.66 - [histone H3]-trimethyl-L-lysine9 demethylase

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Ni-NTA resin column chromatography