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1.14.11.66: [histone H3]-trimethyl-L-lysine9 demethylase

This is an abbreviated version!
For detailed information about [histone H3]-trimethyl-L-lysine9 demethylase, go to the full flat file.

Word Map on EC 1.14.11.66

Reaction

a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
+ 2 2-oxoglutarate + 2 O2 =
a [histone H3]-N6-methyl-L-lysine9
 + 2 succinate + 2 formaldehyde + 2 CO2

Synonyms

5qNCA, AN1060, BHC110, CG15835, CG33182, Dmel\Kdm4A, GASC1, H3K9 demethylase, H3K9 trimethyl demethylase, H3K9-specific demethylase, H3K9/36me3 lysine demethylase, H3K9me2/3 demethylase, H3K9Me3 demethylase, H3K9me3 histone demethylase, H3K9me3-specific demethylase, histone demethylase, histone demethylase JmjD2A, histone demethylase JMJD2A/KDM4A, histone demethylase JMJD2B, histone H3 demethylase, histone H3 Lys 9 demethylase, histone H3K9 demethylase, histone H3K9/H3K36 trimethyldemethylase, histone lysine demethylase, histone-3 lysine-9 di-/tri-methyl demethylase, JDHM3A, JHDM2A, JHDM2B, JHDM3A, JmjC histone lysine demethylase, JmjC-domain-containing histone demethylase 3A, JMJD1A, JMJD1B, JMJD2, JMJD2(1), JMJD2(2), JMJD2A, JMJD2A demethylase, JMJD2A/KDM4A, JMJD2B, JMJD2b histone demethylase, JMJD2C, JMJD2D, jumonji C-domaincontaining histone demethylase 3A, jumonji domain containing 2A, Jumonji domaincontaining demethylase, JumonjiC-domain-containing histone demethylase, JumonjiD2A, KDM1, KDM2B, Kdm3a, Kdm3b, KDM4, KDM4A, KDM4A lysine demethylase, KDM4A/JMJD2A, KDM4B, KDM4B/JMJD2B histone demethylase, Kdm4c, KDM4D, KDM4E, KdmA, KIAA0601, LD33386, LSD1, LSD1 demethylase, LSD1 H3 demethylase, lysine-specific demethylase 1, lysine-specific demethylase 4A, lysine-specific demethylase 4B, lysine-specific demethylase 4C, lysine-specific demethylase 4D, More, testis-enriched histone demethylase, tridemethylase of H3K9, trimethylated histone H3-lysine 9-specific demethylase, trimethyllysine-specific histone demethylase, trimethyllysine-specific JmjC HDM, [histone H3]-lysine-9 demethylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.66 [histone H3]-trimethyl-L-lysine9 demethylase

Specific Activity

Specific Activity on EC 1.14.11.66 - [histone H3]-trimethyl-L-lysine9 demethylase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00029
0.0004
recombinant isozyme JMJD2B, pH 7.5, 22°C, substrate CSB-K297me3
0.0005
0.0006
recombinant isozyme JMJD2A, pH 7.5, 22°C, substrate CSB-K448me3
0.00064
recombinant isozyme JMJD2A, pH 7.5, 22°C, substrate CSB-K297me3
0.00095
recombinant isozyme JMJD2B, pH 7.5, 22°C, substrate CDYL1-K135me3
0.001
0.0011
recombinant isozyme JMJD2A, pH 7.5, 22°C, substrate CSB-K170me3
0.00143
recombinant isozyme JMJD2B, pH 7.5, 22°C, substrate CSB-K1054me3
0.0015
recombinant isozyme JMJD2C, pH 7.5, 22°C, substrate CSB-K297me3
0.00163
recombinant isozyme JMJD2C, pH 7.5, 22°C, substrate CSB-K1054me3
0.00188
recombinant isozyme JMJD2A, pH 7.5, 22°C, substrate WIZ-K305me3
0.0019
0.002
recombinant isozyme JMJD2B, pH 7.5, 22°C, substrate CSB-K170me3
0.00212
recombinant isozyme JMJD2C, pH 7.5, 22°C, substrate G9a-K185me3
0.00232
recombinant isozyme JMJD2C, pH 7.5, 22°C, substrate CSB-K448me3
0.0024
recombinant isozyme JMJD2B, pH 7.5, 22°C, substrate G9a-K185me3
0.0025
recombinant isozyme JMJD2B, pH 7.5, 22°C, substrate CSB-K448me3
0.0026
recombinant isozyme JMJD2A, pH 7.5, 22°C, substrate G9a-K185me3
0.0031
recombinant isozyme JMJD2C, pH 7.5, 22°C, substrate WIZ-K305me3
0.0034
recombinant isozyme JMJD2C, pH 7.5, 22°C, substrate CDYL1-K135me3
0.0035
recombinant isozyme JMJD2B, pH 7.5, 22°C, substrate WIZ-K305me3
additional information
-
specific isozyme activities with non-histone substrates, overview