1.1.5.3: glycerol-3-phosphate dehydrogenase

This is an abbreviated version!
For detailed information about glycerol-3-phosphate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.5.3

Reaction

sn-glycerol 3-phosphate
+
a quinone
=
glycerone phosphate
+
a quinol

Synonyms

DsFAD-GPDH, FAD-dependent glycerol-3-phosphate dehydrogenase, FAD-G3PDH, FAD-glycerol phosphate dehydrogenase, FAD-GPDH, FAD-linked glycerol-3-phosphate dehydrogenase, flavin adenine dinucleotide-dependent glycerol-3-phosphate dehydrogenase, flavin-linked glycerol-3-phosphate ubiquinone oxidoreductase, flavoprotein-dependent glycerol-3-phosphate dehydrogenase, G3PD, GDP, GlpO, glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate dehydrogenase 1, glycerol-3-phosphate dehydrogenase 2, glycerol-3-phosphate oxidoreductase, glycerophosphate dehydrogenase, GPD1, GPD2, GPDH, mGPDH, mitochondrial glycerol-3-phosphate dehydrogenase, mitochondrial sn-glycerol 3-phosphate dehydrogenase, mtG3PDH, putG3PDH, SDP6, sn-glycerol 3-phosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.3 glycerol-3-phosphate dehydrogenase

Activating Compound

Activating Compound on EC 1.1.5.3 - glycerol-3-phosphate dehydrogenase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Bathocuproine
-
slight activation
cardiolipin
-
when functioning with hydrophobic electron acceptor essential in both leaflets of the membrane
chloroform
-
slight activation
cytochrome c
-
role of cyt c in activation of glycerol-3-phosphate and succinate oxidation in frozenthawed mitochondria
detergent
-
FAD
-
stimulates the reaction with phenazine methosulfate and methylene blue. 20% increase in activity of the reaction with phenazine methosulfate with a half-maximal concentration of 200 nM
FMN
-
stimulates the reaction with phenazine methosulfate. 6fold increase in activity with a half-maximal concentration of 0.13 mM
Phospholipid
-
detergent-depleted enzyme requires exogenous phospholipid or nondenaturing detergent for activity
sodium oleate
-
activates