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1.1.5.3: glycerol-3-phosphate dehydrogenase

This is an abbreviated version!
For detailed information about glycerol-3-phosphate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.5.3

Reaction

sn-glycerol 3-phosphate
+
a quinone
=
glycerone phosphate
+
a quinol

Synonyms

DsFAD-GPDH, EC 1.1.2.1, EC 1.1.99.5, FAD-dependent glycerol-3-phosphate dehydrogenase, FAD-G3PDH, FAD-glycerol phosphate dehydrogenase, FAD-GPDH, FAD-linked glycerol-3-phosphate dehydrogenase, flavin adenine dinucleotide-dependent glycerol-3-phosphate dehydrogenase, flavin-linked glycerol-3-phosphate ubiquinone oxidoreductase, flavoprotein-dependent glycerol-3-phosphate dehydrogenase, G3PD, GDP, GLPD, GlpO, glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate dehydrogenase 1, glycerol-3-phosphate dehydrogenase 2, glycerol-3-phosphate oxidoreductase, glycerophosphate dehydrogenase, GmGPDH12, GPD1, GPD2, GPDH, mGPDH, mitochondrial glycerol-3-phosphate dehydrogenase, mitochondrial sn-glycerol 3-phosphate dehydrogenase, mtG3PDH, putG3PDH, SDP6, sn-glycerol 3-phosphate dehydrogenase, sn-glycerol-3-phosphate dehydrogenase, ZmGPDH6

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.3 glycerol-3-phosphate dehydrogenase

Reference

Reference on EC 1.1.5.3 - glycerol-3-phosphate dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dawson, A.P.; Thorne, C.J.R.
L-3-Glycerophosphate dehydrogenase from pig brain mitochondria
Methods Enzymol.
41B
254-259
1978
Sus scrofa
-
Manually annotated by BRENDA team
Halsey, Y.D.
Flavin-linked mitochondrial alpha-glycerophosphate dehydrogenase of Candida utilis
Biochim. Biophys. Acta
682
387-394
1982
Saccharomyces cerevisiae, Cyberlindnera jadinii
Manually annotated by BRENDA team
Cottingham, I.R.; Ragan, C.I.
Purification and properties of L-3-glycerophosphate dehydrogenase from pig brain mitochondria
Biochem. J.
192
9-18
1980
Sus scrofa
Manually annotated by BRENDA team
Unemoto, T.; Hayashi, M.; Hayashi, M.
Partial purification and properties of respiratory chain-linked l-glycerol 3-phosphate dehydrogenase from a marine bacterium, Vibrio alginolyticus
J. Biochem.
90
619-628
1981
Vibrio alginolyticus
Manually annotated by BRENDA team
Cottingham, I.R.; Ragan, C.I.
Purification and properties of mitochondrial L-3-glycerophosphate-ubiquinone oxidoreductase
Biochem. Soc. Trans.
6
1307-1310
1978
Sus scrofa
Manually annotated by BRENDA team
Dawson, A.P.; Thorne, C.J.R.
Preparation and some properties of L-3-glycerophosphate dehydrogenase from pig brain mitochondria
Biochem. J.
111
27-34
1969
Sus scrofa
Manually annotated by BRENDA team
Weiner, J.H.; Heppel, L.A.
Purification of the membrane-bound and pyridine nucleotide-independent L-glycerol 3-phosphate dehydrogenase from Escherichia coli
Biochem. Biophys. Res. Commun.
47
1360-1365
1972
Escherichia coli
Manually annotated by BRENDA team
Schryvers, A.; Weiner, J.H.
The anaerobic sn-glycerol-3-phosphate dehydrogenase of Escherichia coli. Purification and characterization
J. Biol. Chem.
256
9959-9965
1981
Escherichia coli
Manually annotated by BRENDA team
Schryvers, A.; Lohmeier, E.; Weiner, J.H.
Chemical and functional properties of the native and reconstituted forms of the membrane-bound, aerobic glycerol-3-phosphate dehydrogenase of Escherichia coli
J. Biol. Chem.
253
783-788
1978
Escherichia coli
Manually annotated by BRENDA team
Robinson, J.J.; Weiner, J.H.
The effect of amphipaths on the flavin-linked aerobic glycerol-3-phosphate dehydrogenase from Escherichia coli
Can. J. Biochem.
58
1172-1178
1980
Escherichia coli
Manually annotated by BRENDA team
Beleznai, Z.; Szalay, L.; Jancsik, V.
Ca2+ and Mg2+ as modulators of mitochondrial L-glycerol-3-phosphate dehydrogenase
Eur. J. Biochem.
170
631-636
1988
Rattus norvegicus
Manually annotated by BRENDA team
Beleznai, Z.; Jancsik, V.
Role of cardiolipin in the functioning of mitochondrial L-glycerol-3-phosphate dehydrogenase
Biochem. Biophys. Res. Commun.
159
132-139
1989
Rattus norvegicus
Manually annotated by BRENDA team
Beleznai, Z.; Amler, E.; Jancsik, V.; Rauchova, H.; Drahota, Z.
Incorporation of mitochondrial L-glycerol-3-phosphate dehydrogenase into liposomes; effect of sodium oleate and calcium ions
Biochim. Biophys. Acta
1018
72-76
1990
Rattus norvegicus
Manually annotated by BRENDA team
MacDonald, M.J.; Brown, L.J.
Calcium activation of mitochondrial glycerol phosphate dehydrogenase restudied
Arch. Biochem. Biophys.
326
79-84
1996
Rattus norvegicus
Manually annotated by BRENDA team
Shen, W.; Wei, Y.; Dauk, M.; Zheng, Z.; Zou, J.
Identification of a mitochondrial glycerol-3-phosphate dehydrogenase from Arabidopsis thaliana: evidence for a mitochondrial glycerol-3-phosphate shuttle in plants
FEBS Lett.
536
92-96
2003
Arabidopsis thaliana
Manually annotated by BRENDA team
Colussi, T.; Parsonage, D.; Boles, W.; Matsuoka, T.; Mallett, T.C.; Karplus, P.A.; Claiborne, A.
Structure of alpha-glycerophosphate oxidase from Streptococcus sp.: a template for the mitochondrial alpha-glycerophosphate dehydrogenase
Biochemistry
47
965-977
2008
Streptococcus sp.
Manually annotated by BRENDA team
Vrbacky, M.; Drahota, Z.; Mracek, T.; Vojtiskova, A.; Jesina, P.; Stopka, P.; Houstek, J.
Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria
Biochim. Biophys. Acta
1767
989-997
2007
Mesocricetus auratus
Manually annotated by BRENDA team
Yang, W.; Cao, Y.; Sun, X.; Huang, F.; He, Q.; Qiao, D.; Bai, L.
Isolation of a FAD-GPDH gene encoding a mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase from Dunaliella salina
J. Basic Microbiol.
47
266-274
2007
Dunaliella salina (Q06B39), Dunaliella salina
Manually annotated by BRENDA team
Quettier, A.L.; Shaw, E.; Eastmond, P.J.
SUGAR-DEPENDENT6 encodes a mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase, which is required for glycerol catabolism and post-germinative seedling growth in Arabidopsis
Plant Physiol.
148
519-528
2008
Arabidopsis thaliana
Manually annotated by BRENDA team
Yeh, J.I.; Chinte, U.; Du, S.
Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism
Proc. Natl. Acad. Sci. USA
105
3280-3285
2008
Escherichia coli (P13035), Escherichia coli
Manually annotated by BRENDA team
Koza, R.A.; Kozak, U.C.; Brown, L.J.; Leiter, E.H.; MacDonald, M.J.; Kozak, L.P.
Sequence and tissue-dependent RNA expression of mouse FAD-linked glycerol-3-phosphate dehydrogenase
Arch. Biochem. Biophys.
336
97-104
1996
Mus musculus (Q64521), Mus musculus
Manually annotated by BRENDA team
Rauchova, H.; Fato, R.; Drahota, Z.; Lenaz, G.
Steady-state kinetics of reduction of coenzyme Q analogs by glycerol-3-phosphate dehydrogenase in brown adipose tissue mitochondria
Arch. Biochem. Biophys.
344
235-241
1997
Mesocricetus auratus, Periplaneta americana
Manually annotated by BRENDA team
Larsson, C.; Pahlman, I.L.; Ansell, R.; Rigoulet, M.; Adler, L.; Gustafsson, L.
The importance of the glycerol 3-phosphate shuttle during aerobic growth of Saccharomyces cerevisiae
Yeast
14
347-357
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Denton, R.
Regulation of mitochondrial dehydrogenases by calcium ions
Biochim. Biophys. Acta
1787
1309-1316
2009
Rattus norvegicus (P35571)
Manually annotated by BRENDA team
Daoud, H.; Gruchy, N.; Constans, J.M.; Moussaoui, E.; Saumureau, S.; Bayou, N.; Amy, M.; Vedrine, S.; Vu, P.Y.; Roetig, A.; Laumonnier, F.; Vourch, P.; Andres, C.R.; Leporrier, N.; Briault, S.
Haploinsufficiency of the GPD2 gene in a patient with nonsyndromic mental retardation
Hum. Genet.
124
649-658
2009
Homo sapiens (P43304), Homo sapiens
Manually annotated by BRENDA team
Kota, V.; Rai, P.; Weitzel, J.M.; Middendorff, R.; Bhande, S.S.; Shivaji, S.
Role of glycerol-3-phosphate dehydrogenase 2 in mouse sperm capacitation
Mol. Reprod. Dev.
77
773-783
2010
Mus musculus (Q64521), Mus musculus
Manually annotated by BRENDA team
Rauchova, H.; Vokurkova, M.; Drahota, Z.
Idebenone-induced recovery of glycerol-3-phosphate and succinate oxidation inhibited by digitonin
Physiol. Res.
61
259-265
2012
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Sato, T.; Morita, A.; Mori, N.; Miura, S.
The role of glycerol-3-phosphate dehydrogenase 1 in the progression of fatty liver after acute ethanol administration in mice
Biochem. Biophys. Res. Commun.
444
525-530
2014
Mus musculus
Manually annotated by BRENDA team
Mracek, T.; Drahota, Z.; Houstek, J.
The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues
Biochim. Biophys. Acta
1827
401-410
2013
Rattus norvegicus (P35571)
Manually annotated by BRENDA team
Skodova, I.; Verner, Z.; Bringaud, F.; Fabian, P.; Lukes, J.; Horvatha, A.
Characterization of two mitochondrial flavin adenine dinucleotide-dependent glycerol-3-phosphate dehydrogenases in Trypanosoma brucei
Eukaryot. Cell
12
1664-1673
2013
Trypanosoma brucei, Trypanosoma brucei 29-13
Manually annotated by BRENDA team
Lalle, M.; Camerini, S.; Cecchetti, S.; Finelli, R.; Sferra, G.; Mueller, J.; Ricci, G.; Pozio, E.
The FAD-dependent glycerol-3-phosphate dehydrogenase of Giardia duodenalis: an unconventional enzyme that interacts with the g14-3-3 and it is a target of the antitumoral compound NBDHEX
Front. Microbiol.
6
544
2015
Giardia intestinalis, Giardia intestinalis WB-C6
Manually annotated by BRENDA team
Rauchova, H.; Vokurkova, M.; Drahota, Z.
Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate
Int. J. Biochem. Cell Biol.
53
409-413
2014
Mesocricetus auratus, Rattus norvegicus
Manually annotated by BRENDA team
Singh, G.
Mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase: a target for cancer therapeutics
Pharmaceuticals
7
192-206
2014
Homo sapiens
Manually annotated by BRENDA team
Orr, A.L.; Ashok, D.; Sarantos, M.R.; Ng, R.; Shi, T.; Gerencser, A.A.; Hughes, R.E.; Brand, M.D.
Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase
PLoS ONE
9
e89938
2014
Rattus norvegicus (P35571), Mus musculus (Q64521), Mus musculus C57BL/6 (Q64521), Rattus norvegicus Wistar (P35571)
Manually annotated by BRENDA team
Pecinova, A.; Alan, L.; Brazdova, A.; Vrbacky, M.; Pecina, P.; Drahota, Z.; Houstek, J.; Mracek, T.
Role of mitochondrial glycerol-3-phosphate dehydrogenase in metabolic adaptations of prostate cancer
Cells
9
1764
2020
Homo sapiens (P43304)
Manually annotated by BRENDA team
Zhao, Y.; Li, X.; Wang, F.; Zhao, X.; Gao, Y.; Zhao, C.; He, L.; Li, Z.; Xu, J.
Glycerol-3-phosphate dehydrogenase (GPDH) gene family in Zea mays L. Identification, subcellular localization, and transcriptional responses to abiotic stresses
PLoS ONE
13
e0200357
2018
Zea mays
Manually annotated by BRENDA team
Zhao, Y.; Li, X.; Zhang, Z.; Pan, W.; Li, S.; Xing, Y.; Xin, W.; Zhang, Z.; Hu, Z.; Liu, C.; Wu, X.; Qi, Z.; Xin, D.; Chen, Q.
GmGPDH12, a mitochondrial FAD-GPDH from soybean, increases salt and osmotic stress resistance by modulating redox state and respiration
Crop J.
9
79-94
2021
Glycine max (I1JFY8)
-
Manually annotated by BRENDA team
Clarke, K.J.; Porter, R.K.
The Importance of Calcium ions for determining mitochondrial glycerol-3-phosphate dehydrogenase activity when measuring uncoupling protein 1 (UCP1) function in mitochondria isolated from brown adipose tissue
Methods Mol. Biol.
1782
325-336
2018
Rattus norvegicus (P35571)
Manually annotated by BRENDA team